A5079804465- Celiac Disease Research and Management
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Microscopic Colitis
- Child Nutrition and Feeding Issues
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Digestive system and related health
- Metabolism and Genetic Disorders
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Child Nutrition and Water Access
- Food Allergy and Anaphylaxis Research
- Inflammasome and immune disorders
- Inflammatory Bowel Disease
- Infant Health and Development
- Pancreatitis Pathology and Treatment
- Global Financial Crisis and Policies
- Gastrointestinal motility and disorders
- Infant Nutrition and Health
- Liver Diseases and Immunity
- Gastroesophageal reflux and treatments
Ankara University
2016-2025
University Hospital Heidelberg
2023
Heidelberg University
2023
Roche (Switzerland)
2021
Roche (Bosnia-Herzegovina)
2021
AbbVie (United States)
2021
Roche (United Kingdom)
2021
Roche (China)
2021
AbbVie (Ireland)
2021
Gilead Sciences (Germany)
2021
Many screening methods, such as the Screening Tool Risk on Nutritional Status and Growth (STRONGkids) Pediatric Yorkhill Malnutrition Score (PYMS), have been developed to detect malnutrition in pediatric patients. We aimed explore prevalence of risk hospitalized children via symptoms identification contributing factors, examine efficacy tools for children.STRONGkids PYMS were applied 1513 inpatients at 37 hospitals 26 cities from different regions Turkey. Physical measurements collected...
Congenital diarrheal disorders are rare inherited intestinal characterized by intractable, sometimes life-threatening, diarrhea and nutrient malabsorption; some have been associated with mutations in diacylglycerol-acyltransferase 1 (DGAT1), which catalyzes formation of triacylglycerol from diacylglycerol acyl-CoA. We investigated the mechanisms DGAT1 deficiency contributes to failure using patient-derived organoids.We collected blood samples 10 patients, 6 unrelated pedigrees, who presented...
Objective Use of peptide-based formulas supplemented with medium chain triglycerides (MCTs) is considered a beneficial strategy to decrease the tube-feeding associated gastrointestinal tolerance. In children cerebral palsy (CP), overall effects enteral tube feeding as well utility specialized in those intolerance have not been extensively studied. This study aimed evaluate via formula containing MCTs CP terms intolerance, anthropometrics, defecation characteristics and parental satisfaction...
Celiac disease (CD), a common cause of malabsorption, is known to be associated with disorders the skeleton, but there are conflicting data about effect diet on bone metabolism. The aims this study were investigate prevalence osteopenia; identify relationship between mineral density (BMD), serum calcium, and parathyroid hormone levels; determine gluten-free BMD in children celiac disease.The included 32 patients CD (group 1) 82 healthy controls 2). evaluated under 2 subgroups, ie, 16 recent...
BackgroundInflammatory bowel diseases (IBDs) denote a heterogeneous group of disorders associated with an imbalance gut microbiome and the immune system. Importance system in is endorsed by presence IBD-like symptoms several primary immunodeficiencies. A fraction early-onset IBDs presenting more severe disease course incomplete response to conventional treatment assumed be inherited Mendelian fashion, as exemplified recent discovery interleukin (IL)-10 (receptor) deficiency.
Biallelic mutations in SCYL1 were recently identified as causing a syndromal disorder characterized by peripheral neuropathy, cerebellar atrophy, ataxia, and recurrent episodes of liver failure. The occurrence deficiency among patients with previously undetermined infantile cholestasis or acute failure has not been studied; furthermore, little is known regarding the hepatic phenotype.We aimed to identify variants within an exome-sequencing study individuals unknown etiology. Deep clinical...
The present paper aims to provide experts' consensus on diagnosis and management of cow's milk protein allergy (CMPA) among infants children in Turkey, based review available evidence-based guidelines, publications clinical experience. experts agreed that CMPA should be symptomatic evaluation diagnostic elimination diet as followed by implementation an open challenge test after disappearance symptoms confirmation re-appearance symptoms. For breastfed infants, differential involves withdrawal...
Undernutrition is defined as “a condition resulting from imbalanced nutrition or abnormal utilization of nutrients.” In this paper, the term malnutrition used to refer undernutrition. Malnutrition may be driven by poor socioeconomic conditions disease, and it estimated that disease-related (DRM) impacts up 28% hospitalized children in Europe. results alterations gastrointestinal function lead malabsorption macro- micro-nutrients. It can altered gut motility a deficiency stomach acid, which...
The clinical features of patients with celiac disease (CD) are variable. In the present study, and laboratory 109 CD were retrospectively evaluated.In all cases, diagnosis was made by European Society for Paediatric Gastroenterology, Hepatology Nutrition (ESPGHAN) criteria findings, including hematological biochemical analyses, immunoglobulin levels, autoantibodies [antinucler antibody (ANA), antidouble stranded DNA (dsDNA), antimitochondrial (AMA), anti-smooth muscle (ASMA), liver kidney...
In the present study, we aimed to investigate if partially hydrolyzed guar gum (PHGG) can be used safely as a fiber source for treatment of constipation in children and compare its success with most commonly osmotic laxative, lactulose.A randomized prospective controlled study on 61 patients (partially group, n: 31; lactulose 30) was performed. Patients were given or four weeks. Using standardized bowel diary, defecation frequency, stool consistency, presence flatulence abdominal pain...
Background and Aims: Pediatric acute liver failure (PALF) is a life-threatening condition. In Europe, the main causes are viral infections (12%–16%) inherited metabolic diseases (14%–28%). Yet, in up to 50% of cases underlying etiology remains elusive, challenging clinical management, including transplantation. We systematically studied indeterminate PALF referred for genetic evaluation by whole-exome sequencing (WES), analyzed phenotypic biochemical markers, diagnostic yield WES this...
Chronic hepatitis B (CHB) infection is a serious public health problem due to its potential liver disease sequelae and highly expensive medical costs such as the need for transplantation. The aim of this study was quantify burden active CHB in terms mortality morbidity, eligibility antiviral treatment assess various scenarios possible salvage combinations cost-effectiveness.A population cohort from large data base chronic patients constructed stratified according 10-year age groups,...
We assessed how the diagnosis of Celiac Disease (CD) is made and new ESPGHAN guidelines can be applied in children from countries with different resources.A real life prospective study was performed 14 centres 13 Mediterranean countries. Participants were asked to apply usual diagnostic work-up for CD according their facilities.There 1974 patients enrolled study, mean age 4 years, 10 months; 865 male, 1109 female. confirmed 511 (25.9%) unconfirmed 1391 (70.5%) patients; diagnosed as having...
Objective: Increased prevalence of celiac disease (CD) and autoimmune thyroid disorders (ATD) in patients with Type 1 diabetes mellitus (T1D) has been widely reported.Such an association may lead to adverse effects on the growth, bone metabolism fertility, response therapy become difficult.The aim this study was evaluate clinical findings HLA typing results T1D associated CD or ATD.Methods: The ATD evaluated 38 children aged 1.5-16.8years who had followed for 48.3±28 months.Diagnosis based...