A5103128786- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Celiac Disease Research and Management
- Liver Disease and Transplantation
- Infant Nutrition and Health
- Metabolism and Genetic Disorders
- Connective tissue disorders research
- Inflammatory Bowel Disease
- Food Allergy and Anaphylaxis Research
- Liver Diseases and Immunity
- Gastrointestinal Bleeding Diagnosis and Treatment
- Tuberous Sclerosis Complex Research
- Congenital Anomalies and Fetal Surgery
- Inflammasome and immune disorders
- Ethics and Legal Issues in Pediatric Healthcare
- Ophthalmology and Visual Health Research
- Genetic and Kidney Cyst Diseases
- Child Nutrition and Feeding Issues
Karadeniz Technical University
2016-2025
Istanbul University
2023-2024
Universidad CES
2021
Sağlık Bilimleri Üniversitesi
2021
Pediatric Oncology Group
2019
Pediatrics and Genetics
2012
Objective Use of peptide-based formulas supplemented with medium chain triglycerides (MCTs) is considered a beneficial strategy to decrease the tube-feeding associated gastrointestinal tolerance. In children cerebral palsy (CP), overall effects enteral tube feeding as well utility specialized in those intolerance have not been extensively studied. This study aimed evaluate via formula containing MCTs CP terms intolerance, anthropometrics, defecation characteristics and parental satisfaction...
Abstract Background Coronavirus disease 2019 (COVID-19) usually leads to a mild infectious course in children, while serious complications may occur conjunction with both acute infection and neurological symptoms, which have been predominantly reported adults. The these patients vary based on patient age underlying comorbidities. Data clinical features, particularly prognostic factors children adolescents are limited. This study provides concise overview of pediatric COVID-19 cases....
Ischemia-modified albumin (IMA) levels have been shown to correlate with the severity of liver failure in adults. However, role IMA has not evaluated children chronic disease (CLD). We analyzed clinical significance CLD.Thirty-three CLD and 33 healthy were included study. Blood was collected analyze biochemical parameters, oxidant status, IMA. Liver biopsies re-evaluated for fibrosis; severe fibrosis (SF) defined as stage ≥4.THE AND TO ALBUMIN RATIOS (IMARS) WERE SIGNIFICANTLY HIGHER IN...
We aimed to analyze the efficiency of a novel treatment approach, long-term synbiotic supplementation, in addition lifestyle changes children with non-alcoholic fatty liver disease (NAFLD).The study included NAFLD (n=28) and healthy control group (n=30). Children were given 1 capsule/day synbiotics. Anthropometric parameters; biochemical analysis, including ethanol, tumor necrosis factor-α (TNF-α), total oxidant status (TOS) anti-oxidant (TAS), zonulin, fecal calprotectin; ultrasonographic...
ABSTRACT Objective: Continued progress in our understanding of the food protein–induced allergic proctocolitis (FPIAP) will provide development diagnostic tests and treatments. We aimed to identify precisely clinical features natural course disease a large group patients. Also, we investigated predicting risk factors for persistent since influencing parameters has not yet been established. Methods: Infants who were admitted with rectal bleeding had diagnosis 5 different allergy or...
This study aimed to investigate polymorphisms in the genes responsible for encoding cytokines interleukin-6 (IL-6) (-572G/C) (rs1800796) and IL-17 (-197A/G) (rs2275913) patients with celiac disease (CD). We further relationship between CD symptoms histopathological findings these polymorphisms.We compared results those of healthy control subjects establish whether any are involved susceptibility CD. Eighty-four 83 controls were enrolled this study. Children divided into two groups depending...
Particular fibrinogen γ chain mutations occurring in the γ-module induce changes that hamper γ-γ dimerization and provoke intracellular aggregation of mutant fibrinogen, defective export plasma deficiency. The hepatic storage predisposes to development liver disease. This condition has been termed hereditary hypofibrinogenemia with (HHHS). So far, seven such have detected. We are reporting on an additional mutation a 3.5-year-old Turkish child undergoing needle biopsy because concomitance...
Sağ E, Kaya G, Bahat-Özdoğan Karahan SC, İmamoğlu M, Sarıhan H, Çakır M. Acute pancreatitis in children: A single center experience over ten years. Turk J Pediatr 2018; 60: 153-158. (AP) is an inflammatory disease characterized by sudden onset abdominal pain together with elevation of pancreatic enzymes and radiographic changes. Increased incidence AP children have been reported recent reports. In this study; we aimed to analyze the demographic characteristics, etiology, outcome among...
Recurrent acute pancreatic attacks is a rare clinical condition (2-5% of all pancreatis) in children and mainly idiopathic most cases. Sometimes it may be associated with congenital anomalies, metabolic diseases or hereditary conditions. Isovaleric acidemia (IVA) autosomal recessive amino acid metabolism disorder isovaleryl coenzyme A dehydrogenase deficiency presenting the findings such acidosis increased anion gap, hyperammonemia, ketonemia, hypoglycemia, "the odor sweaty feet," abdominal...
We aimed to evaluate the incidence, clinical findings, and risk factors of antibiotic-associated diarrhea (AAD) in hospitalized children without known comorbid diseases.All during 1-year period that fulfilled inclusion criteria were included this study (n = 358). AAD was defined as; ≥2 loose or watery stools per day for a minimum 24 hours antibiotic treatment caused by Clostridioides difficile negative stool tests identifiable infectious agents.During hospitalization, developed 32 (8.93%)...
Alpha-1 antitrypsin deficiency (A1ATD) in one of the most common genetic causes liver disease children. We aimed to analyze clinical characteristics and outcomes patients with A1ATD.This study included A1ATD from five pediatric hepatology units. Demographics, findings, genetics, outcome were recorded (n=25).Eight (32.0%) had homozygous PiZZ genotype while 17 (68.0%) heterozygous genotype. Patients lower alpha-1 levels than PiMZ (37.6±7.7 mg/dL vs. 66.5±22.7 mg/dL, p=0.0001). diagnosed...
Malnutrition may influence neurocognitive development in children by directly affecting the brain structural development, or indirectly children's cognition experience. alters cell numbers, migration, synaptogenesis, and neurotransmission due to inadequate availability of necessary micronutrients support growth. We aimed analyze infants with malnutrition its association long chain polyunsaturated fatty acids (LC-PUFA), levels magnetic resonance spectroscopy (MRS) findings.The study included...
Abstract Background Acute liver failure (ALF) is a rare multisystemic disease occurring in individuals with no history of disease, characterized by coagulopathy and / or hepatic encephalopathy secondary to acute injury. It mostly caused viral infections, drug intoxication, metabolic diseases (MD), can also have an indeterminate etiology. In this study, we aimed evaluate the demographic clinical characteristics outcomes patients that presented our clinic MD‐associated ALF. Methods This...
Autoimmune hepatitis (AIH) is a common pediatric liver disease and long-term remission usually maintained with low dose prednisolone azathioprine (AZA). The aim of this study to evaluate the efficiency AZA monotherapy for maintenance treatment children AIH.This was retrospective analysis 55 AIH. Patients were divided into two groups: combination therapy (CT) group based on therapy. Results these different treatments compared in AIH.The mean age 10.67 ± 4.30 years (61.8% females) follow-up...
The gastrointestinal system is the most commonly affected organ, followed by lungs, in patients with primary immunodeficiency disease (PID). Hence, it common for children PIDs to present symptoms. We aimed analyze clinical and histopathological findings of who were initially admitted pediatric gastroenterology/hepatology clinics subsequently diagnosed identify clues PIDs.The demographic, laboratory, findings, treatment modality, outcomes unit recorded.The study included 24 (58.3% male;...
Esophageal stricture (ES) is an uncommon clinic entity in pediatrics that may be congenital or acquired childhood. Acquired noncaustic ES very rare, and clinical features of affected patients are unknown.We aimed to evaluate the findings, outcomes with aid physicians early referral gastroenterologists.The medical data who were followed our gastroenterology between January 2009 December 2019 reviewed.Acquired was found 12 4,950 (0.24%) underwent endoscopy during study period. The main...
<b><i>Objective:</i></b> We aimed to share our observations on the demographics, clinical characteristics, and outcomes of lymphonodular hyperplasia (LNH) in children. <b><i>Subjects Methods:</i></b> The study included children whom colonoscopy was performed between January 2015 May 2018 (<i>n</i> = 361). Demographics, treatment modalities, patients with LNH were recorded. <b><i>Results:</i></b> found 66...
Amaç: Çölyak hastalığı (ÇH), çocuk yaş grubunda malabsorpsiyonun en önemli nedenlerinden biri olup, çok farklı bulgularla ortaya çıkabilen bir hastalıktır. Zamanla serolojik testlerin artması, güvenli endoskopi koşulları ve doktorların hastalık konusunda farkındalığının artmasıyla birlikte, tanı konulma sıklığı atipik alan hasta sayısı artmıştır. Bu çalışmada, yıllara göre hastalığın klinik, laboratuar histopatolojik bulgularını değerlendirmeyi amaçladık. Gereç Yöntemler: 2008-2019 yılları...
Anemia is a common problem in outpatient clinics, and endoscopic interventions are one of the initial steps to rule out gastrointestinal causes. In this study, we aimed analyze diagnostic yield children with severe anemia.The demographic features, laboratory findings, histopathological findings 65 anemia (hemoglobin <7 g/dL) (mean age 12.1 ± 4.4 years, 73.8% female) who underwent were recorded from files. Patients divided into 2 groups according presence positive and/or examination. Factors...
Patients suffering from hypermobility spectrum disorders (HSDs) present with problems related to the musculoskeletal system and have generalized joint without a diagnosed systemic rheumatological disease. HSDs represent an underlying risk factor for many clinical conditions, such as dysfunctional voiding functional constipation (FC). In this study, we investigated ways detect frequency of HSDs, dysfunction (VD), FC in school-aged children assessed their relationship each other....
Congenital diarrheal disorders (CDDs) are a rare group of enteropathies that typically present in the early few months life and pose diagnostic challenge. We aimed to analyze clinical findings outcome infants with CDDs share experience about genetic testing.Demographic, findings, patients (n = 24) were recorded from hospital files.The onset diarrhea was within neonatal period 45.8% patients. The most frequent causes defects digestion, absorption transport nutrients electrolytes (DATN) 11,...
ABS TRACTAim: The differentiation of inflammatory bowel diseases (IBD) from other gastrointestinal in pediatric patients is highly important and the definitive diagnosis IBD established by endoscopic examination.The use non-invasive methods (clinical symptoms laboratory tests) allows for early accurate referral first step health centers to advanced centers.We aimed investigate effectiveness fecal calprotectin (FC) children. Materials Methods:This retrospective study included who had...
Background Data on peptic ulcers in childhood are insufficient. The aim of this study is to define the frequency and characteristics ulcer disease (PUD) children compare with PUD due H.pylori infection others.Methods Pediatric patients that underwent upper gastrointestinal endoscopy between July 2008 2019 were examined. Age, gender, clinical presentation, location (PU), presence histopathologically hemoglobine values recorded for each paient from hospital file records. Patients divided into...
Background. Wernicke`s encephalopathy (WE) is a coenzyme-induced disease with acute neuropsychiatric symptoms leading to high mortality and morbidity due thiamine deficiency. WE mostly caused by alcoholism in adult populations; however, it often associated gastrointestinal surgical procedures, recurrent vomiting, chronic diarrhea, cancer chemotherapy treatment, systemic diseases, drugs, magnesium deficiency, malnutrition children. Although these predisposing factors are considered be...