Background: Morus nigra L. belongs to the family Moraceae and is frequently used in traditional medicine. Numerous studies have investigated antiproliferative effects of various extracts different species, but involving vitro cytotoxic effect M. extract are very limited. The purpose this study was evaluate phenolic composition antioxidant activity dimethyl sulfoxide (DEM) investigate, for first time, probable human prostate adenocarcinoma (PC-3) cells together with mechanism involved....

ABSTRACT Aim : The purpose of this study was to compare HMGB‐1, TLR4, IL‐1β, IL‐1R1, and TNF‐α levels in patients with mild severe epilepsy those a healthy control group. Methods Children aged 4–17 years, diagnosed for at least three years no progressive neurological disease, metabolic disease or infection, were selected the study. group consisted 28 children one episode week despite receiving more antiepileptic drugs. 29 seizures previous year, only drug, while 27 as IL‐1β investigated...

The purpose of this study was to determine whether irisin is secreted by gastric tumor cells experimentally induced in mice, and also if it has any effect on cancer cachexia.12 out 60 BALB/c mice were used as a control group, while N-nitroso-N-methylurea (MNU) administered orally the remaining 48. After 150 days, surviving sacrificed decapitation, blood stomach, skeletal muscle, brown white adipose tissue specimens collected. Following histopathological evaluation stomach tissues, decided...

Purposes: The aim of this study was to determine the diagnostic significance fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in sera patients with renal cell cancer. Materials and Methods: In study, 48 individuals were evaluated. patient group included 23 subjects diagnosed tumor, control 25 healthy individuals. Patients tumor received surgical treatment consisting radical or partial nephrectomy. Blood specimens collected serum FNDC5/Irisin carcinoembryonic antigen...

To investigate the efficacy of signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) as a novel biomarker renal tumors.48 individuals were included in study. The patient group (Group-1) consisted 23 subjects diagnosed with tumor, and control (Group-2) 25 healthy individuals. Patients tumor received surgical treatment consisting radical or partial nephrectomy. Blood specimens collected following overnight fasting. Signal (SCUBE-1), soluble urokinase plasminogen activator receptor...

Studies have investigated expression status of galectin-3 (Gal-3), but very little is known about the importance circulating Gal-3 in patients with breast cancer (BC). The purpose study was to investigate clinical significance and potential diagnostic value plasma levels BC.Fifty-two BC 35 age-matched healthy controls were enrolled. Levels controls. determined using ELISA method.Serum significantly higher than (P = 0.002). did not differ according patients' statuses lymph node involvement,...

Although several studies have investigated the cytotoxic effects of different Dianthus species, there has been only limited research into effect carmelitarum. The purpose this was to evaluate phenolic characterization and D. carmelitarum on human colon cancer (WiDr) cells possible mechanisms involved. Total polyphenolic contents (TPC) extract were evaluated using Folin-Cioceltau method reversed-phase high performance liquid chromatography (RP-HPLC), respectively. activity determined...

Acute myeloid leukemia (LAML) is one of the most prevalent hematological malignancies. In recent years, while targeted approaches have shown promise in fight against cancer, treatability and prognosis patients remain inadequate due to shortage drugs. Noncoding RNAs, especially circular RNA (circRNA) microRNA (miRNA), been play a unique role tumor development. This study aims identify disease-associated circRNA-miRNA-mRNA network by bioinformatic analysis investigate mechanisms development...

Although several studies have investigated the cytotoxic effects of different

Abstract: Objective: Cancer is one of the most deadly types disease and evasion from apoptosis unstoppable cell proliferation are accepted as its distinctive features. Many studies have evaluated cytotoxic effect different Morus species but, there no study about rubra. In this we aimed to evaluate phenolic composition, antioxidant properties acidified dimethyl sulfoxide extract M. rubra (AMRE). Method: Antioxidant properties, composition AMRE were determined using spectrophotometric methods,...

Background. The HELLP syndrome (Hemolysis, Elevated Liver enzymes and Low Platelets) is a complication of severe pre-eclampsia, condition characterized by oxidative stress elevation caused disequilibrium between lipid peroxidation antioxidant defense mechanisms, which, in turn, results endothelial compromise free radical-mediated cell damage. While several studies have examined the relationship pre-eclampsia stress, research investigating hypoxic status limited.Objectives. aim this study was...

The purpose of this study was to investigate the phytochemical analysis D. pentaphyllum and its cytotoxic activity on human cervical cancer (HeLa) cells with possible mechanisms. Total phenolic contents (TPC) extract were evaluated using spectrophotometric method RP-HPLC, respectively. effect MTT assay. mechanism also in terms apoptosis, cell cycle, mitochondrial membrane potential (MMP) fluorometric methods. TPC calculated as 68.9±2.3 mg gallic acid equivalent per g sample quercetin...

Cancer is the second leading cause of death and gastric cancer fourth most common type worldwide. Investigation autoantibodies in patients has been a popular research area recent years. The aim current study was to investigate carbonic anhydrase I II (CA II) plasma subjects with based on information considerations autoimmune relation cancer. Anti-CA antibody levels were investigated by ELISA samples fifty two thirty five healthy peers. titers group significantly higher compared control (p =...

Cancer, one of the principal causes death, is a global social health problem. Autoantibodies developed against organism's self-antigens are detected in sera subjects with cancer. In recent years carbonic anhydrase (CA) I and II autoantibodies have been shown some autoimmune diseases carcinomas, but mechanisms underlying this immune response not yet explained. The aim study was to evaluate CA patients acute myeloid leukemia (AML) provide novel perspective regarding basis disease.Anti-CA...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Mentese A, Erkut N, Demir S, et al. Serum carbonic anhydrase I and II autoantibodies in patients with chronic lymphocytic leukaemia. Central European Journal of Immunology. 2018;43(3):276-280. doi:10.5114/ceji.2018.80046. APA Mentese, A., Erkut, N., Demir, S., Yaman, Sumer, & Erdem, M. (2018). Immunology, 43(3), 276-280. https://doi.org/10.5114/ceji.2018.80046 Chicago Ahmet, Nergiz Selim Serap Ozer Aysegul...

Malnutrition may influence neurocognitive development in children by directly affecting the brain structural development, or indirectly children's cognition experience. alters cell numbers, migration, synaptogenesis, and neurotransmission due to inadequate availability of necessary micronutrients support growth. We aimed analyze infants with malnutrition its association long chain polyunsaturated fatty acids (LC-PUFA), levels magnetic resonance spectroscopy (MRS) findings.The study included...

Postprandial lipemia (PPL) causes endothelial dysfunction by causing damage to lipoproteins that remain rich in triglycerides. Endocan is a proteoglycan with increased tissue expression, activation, and neovascularization. The aim of the study was examine circulating endocan levels PPL subjects considering degree response according high-fat test meal. other determine association between inflammatory factors. Fifty-four hyperlipidemic 28 normolipidemic consumed Endocan, sICAM-1, sVCAM-1,...

Breast cancer mortality rates after metastasis is high. Urokinase plasminogen activator receptor (uPAR) and carbonic anhydrase IX (CAIX) play very important roles during tumor cell invasion metastasis. The purpose of this study was to evaluate plasma levels uPAR CAIX the effect anthracycline-based chemotherapy on these biomarkers in patients with operable breast cancer.Sixty-five 25 age-matched healthy controls were enrolled. Levels investigated before adjuvant chemotherapy. Basal...