A5031755463- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Hypothalamic control of reproductive hormones
- Circadian rhythm and melatonin
- Stress Responses and Cortisol
- Biochemical Analysis and Sensing Techniques
- Ovarian function and disorders
- Pain Mechanisms and Treatments
- Hormonal and reproductive studies
- Neuroscience and Neuropharmacology Research
- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Apelin-related biomedical research
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Exercise and Physiological Responses
- Sperm and Testicular Function
- Menstrual Health and Disorders
- Neuropeptides and Animal Physiology
- Plant Reproductive Biology
- Diet and metabolism studies
- Dietary Effects on Health
- Neuroendocrine regulation and behavior
- Nasal Surgery and Airway Studies
- Sulfur Compounds in Biology
Fırat University
2015-2025
University School
2021
Balıkesir University
2021
Elazığ Eğitim ve Araştırma Hastanesi
2020
Recep Tayyip Erdoğan University
2018
Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi
2017
Siirt Üniversitesi
2017
Karadeniz Technical University
2008-2016
Czech Academy of Sciences, Institute of Microbiology
2016
Yeditepe University
2010
Bee pollen has been used as an apitherapy agent for several centuries to treat burns, wounds, gastrointestinal disorders, and various other diseases. The aim of our study was investigate the hepatoprotective effects chestnut bee against carbon tetrachloride (CCI4)-induced liver damage. Total phenolic content, flavonoid, ferric reducing/antioxidant power, DPPH radical activity measurements were antioxidant capacity determinants pollen. conducted in rats seven groups. Two different...
Our objective was to identify the antioxidant properties of honeybee products from Turkey, chestnut honey, pollen, propolis, and royal jelly, their hepatoprotective activity against CCl4-induced hepatic damage in rats.Animals were fed with for 7 days following CCl4 injection. Development liver oxidative stress monitored by measuring activities enzymes alanine transaminase, aspartate malondialdehyde, superoxide dismutase, catalase. Antioxidant capacities bee identified using FRAP DPPH assays,...
Demyelination is commonly observed in neurodegenerative disorders, including multiple sclerosis (MS). Biotin supplementation known to stabilize MS progression. To reduce the effective dose of biotin, we synthesized a new and superior form complex magnesium ionically bound biotin (MgB) compared its dose-dependent effect with alone after inducing demyelination using lysolecithin (LPC) rats. Myelination was assessed luxol fast blue staining immunostaining against MBP protein, revealing that...
This study evaluates acetylcholinesterase (AChE) enzyme activity levels, oxidative stress parameters, histopathological findings, and serum melatonin levels in rat brain tissue. 32 male Wistar Albino rats were randomly divided into four groups: Control, Light, Dark, Dim light (n = 8 each group). After a 30 day experiment, tissues collected to measure AChE, glutathione S-transferase (GST), (GSH), malondialdehyde (MDA) conduct analyses. Serum also measured. In this study, we observed...
Melatonin, the main secretory product of pineal gland, has been shown to be potentially effective in prevention numerous types neurodegenerative disorders which free radical processes are involved. Homocysteine (Hcy), an independent risk factor for atherosclerosis, undergoes auto-oxidation and generates reactive oxygen species. The purpose this study was test whether intracerebroventricular (ICV) injection Hcy leads neural lipid peroxidation also investigate protective effects melatonin on...
The purpose of this study was to determine whether irisin is secreted by gastric tumor cells experimentally induced in mice, and also if it has any effect on cancer cachexia.12 out 60 BALB/c mice were used as a control group, while N-nitroso-N-methylurea (MNU) administered orally the remaining 48. After 150 days, surviving sacrificed decapitation, blood stomach, skeletal muscle, brown white adipose tissue specimens collected. Following histopathological evaluation stomach tissues, decided...
<b><i>Introduction:</i></b> Obesity is known to cause sexual dysfunction including erectile and poor semen quality. Lifestyle modifications such as exercise have increasingly been more recognized lower the likelihood of having or infertility in obese men. In this context, an exercise-mimetic hormone, irisin has a potential improve obesity-related reproductive dysfunctions. We aimed elucidate possible effects on high-fat diet (HFD)-induced male rats....
The aim of this study was to determine the modulatory effects peptide 234 (p234) (an antagonist GPR54 receptors) on kisspeptin and RF9 RFamide-related antagonist)-induced changes in reproductive functions energy balance female rats. Female Sprague-Dawley rats were weaned postnatal day (pnd) 21. animals intracerebroventricularly cannulated under general anesthesia pnd 23. Groups injected with kisspeptin, RF9, p234, plus or daily. experiments ended first diestrus following 60. Kisspeptin alone...
Physical exercise and body muscle/fat mass are known to affect the endocrine system, puberty onset reproductive health. However, potential effects of irisin, an adipo-myokine exercise-induced hormone, have not yet been fully elucidated on maturation. Therefore, present study aimed determine irisin administration pubertal maturation system in female male rats. Daily i.p. injection (100 ng/kg; from postnatal day 21 for about 10 weeks) delayed ages at vaginal opening (as external index onset)...
Opiate abuse has been a matter of serious concern in male adolescents. This study investigates the effects chronic morphine administration on serum luteinizing hormone (LH), follicle-stimulating (FSH), testosterone levels, testicular histology, and body testes weight developing rats. Animals were subcutaneously injected with (5 mg/kg) or saline (1 mL/kg) twice daily for 30 days. Body determinations injections carried out under light ether anesthesia. At end experiments, rats decapitated...
We aimed to investigate the effects of asprosin on diabetes with a focus serum glucose, irisin, ghrelin, leptin levels and hepatic triglycerides (TG), cholesterol, low-density lipoprotein (LDL).Asprosin (10 µg/kg) was administered intraperitoneally four times at 3-day intervals then blood parameters above mentioned were investigated in control diabetic mice.The administration increased glucose level healthy animals (p = .05) whereas it did not change animals. In addition, while decreased...
We have investigated effects of micro- and kappa-opioid agonists antagonists on plasma oxytocin levels noradrenaline content in the supraoptic nucleus (SON) paraventricular (PVN) 20-day pregnant rats. beta-Endorphin, oxytocin, estrogen progesterone profiles late parturient rats were also sought. Stage estrous cycle was monitored by vaginal smear, pro-estrous animals left overnight with male. In first set experiments, decapitated days 20 21 after delivery second pup. set,...
The main aim of this study was to investigate the effects irisin on asprosin, leptin, glucose levels and lipid profile in healthy obese male female rats.Irisin subcutaneously administered with osmotic minipumps at dose 100 ng/kg/day for 28 days then, serum were investigated.Irisin infusion increased asprosin rats (p = .02) but not rats. Irisin inhibited obesity-induced high glucose, low-density lipoprotein (LDL), triglyceride (TG) leptin all groups; however, it did lead any change both...
We have investigated the effects of thinner inhalation on serum LH, FSH and testosterone levels together with changes in hypothalamic catecholaminergic system male rat. A control group inhaled normal air ventilation. The remaining animals were divided into two groups exposed to paint a glassy cage for 15 or 30 d. Toluene concentration (the largest constituent thinner, 66%) was set at 3000 ppm air. At end, all decapitated blood samples obtained. Serum LH measured by RIA enzyme immunoassay....
Background and Objective: Despite important advances in available knowledge, management of neuropathic pain remains incomplete, results from experimental clinical studies indicate that some anticonvulsants show promise for treating pain. The aim this study was to assess the antinociceptive efficacy levetiracetam (LEV, ucb L059) a mice model painful diabetic neuropathy using vivo nociceptive behavioral ‘hot‐plate test.’ Methods: hot‐plate test consisted placing individual (adult male Balb/C)...
Objective: Apelin-13 is an endogenous peptide with potential analgesic action, although the sites of its effects remain uncertain and results are even controversial regard to pain modulating action. This study evaluated possible pain-modulating action peripherally administered apelin-13 using heat-induced, withdrawal latency thermal stimuli, acute model in mice. Involvement peripheral mechanisms was tested, by intracellular calcium concentrations as a key signal for nociceptive transmission,...