A5064504988- Regulation of Appetite and Obesity
- Hypothalamic control of reproductive hormones
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Toxic Organic Pollutants Impact
- Neuroendocrine regulation and behavior
- Effects and risks of endocrine disrupting chemicals
- Diet and metabolism studies
- Stress Responses and Cortisol
- Ovarian function and disorders
- Neuropeptides and Animal Physiology
- Carcinogens and Genotoxicity Assessment
- Estrogen and related hormone effects
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Neuropharmacology Research
- thermodynamics and calorimetric analyses
- Genetics, Aging, and Longevity in Model Organisms
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Plant Reproductive Biology
- Dietary Effects on Health
- Anesthesia and Neurotoxicity Research
- Sleep and Wakefulness Research
- Reproductive Biology and Fertility
- Thermal Regulation in Medicine
Yeditepe University
2016-2025
Izmir University
2024-2025
Dokuz Eylül University
2020-2025
İstanbul Sabahattin Zaim Üniversitesi
2025
Cambridge University Press
2022
New York University Press
2022
Hormel (United States)
2022
Maltepe University
2013-2022
Ghent University
2022
Türkisch-Deutsche Universität
2021
Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased a concomitant event or directly contributes to melatonin's neuroprotective effect, and (ii) how regulates signaling pathway after FCI. In this study, we showed Akt was intensively phosphorylated at the Thr308 activation loop as compared with Ser473 by Melatonin treatment...
Melatonin is synthesized and released by the pineal gland in a circadian rhythm, many of its peripheral actions are mediated via membrane MT1 MT2 receptors. Apart from metabolic functions, melatonin potent neuroprotective molecule owing to antioxidative actions. The roles effects cell signaling after cerebral ischemia remain unknown. With use knockout (mt1/2(-/-) ) mice treated with melatonin, we evaluated brain injury, edema formation, inducible nitric oxide synthase (iNOS) activity,...
<b><i>Background:</i></b> Melanin-concentrating hormone (MCH)-expressing neurons have been implicated in regulation of energy homeostasis and reward, yet the role their electrical activity short-term appetite reward modulation has not fully understood. <b><i>Objectives:</i></b> We investigated behavioral physiological effects MCH neuron manipulations. <b><i>Methods:</i></b> used optogenetic chemogenetic approaches...
Abstract Norepinephrine (NE) is a well-known appetite regulator, and the nor/adrenergic system targeted by several anti-obesity drugs. To better understand circuitry underlying adrenergic control, here we investigated paraventricular hypothalamic nucleus (PVN), key brain region that integrates energy signals receives dense input, using mouse model. We found PVN NE level increases with of deficit decreases food access. This pattern recapitulated innervating catecholaminergic axon terminals...
Mortality rate of the crush victims in Marmara earthquake August 1999 was compared with conclusions arrived after making thermodynamic assessment data acquired previous earthquakes. Entropic age concept found very helpful while assessing data. group 0-9 years old 0 because basal metabolic (BMR) these children low. The happened at 3:03 a.m. morning and it probably coldest time day; therefore, were losing sufficient heat to avoid hyperpraxia, where body temperature reaches 40°C or above. As...
Introduction: The LBR gene has two primary functions: maintaining the structural integrity of nuclear envelope and playing a role in cholesterol biosynthesis. Heterozygous variants have been associated with PelgerHuët anomaly (PHA, OMIM #169400) while homozygous or compound heterozygous mutations rhizomelic skeletal dysplasia, without Pelger-Huët anomaly(SKPHA, #618019) Greenberg dysplasia (GRBGD,OMIM #215140). Case Presentation: We report 4-year-old boy presenting short stature limbs his...
Abstract Aim Mitochondria play key roles in neuronal activity, particularly modulating agouti‐related protein (AgRP) and proopiomelanocortin (POMC) neurons the arcuate nucleus of hypothalamus (ARC), which regulates food intake. FAM163A, a newly identified protein, is suggested to be part mitochondrial proteome, though its functions remain largely unknown. This study aimed investigate effects Fam163a knockdown dysfunction on intake, AgRP neuron function hypothalamus. Methods Male C57BL/6...
Abstract Pesticides often cause environmental pollution and adverse effects on human health. We have chosen four structurally different pesticides (endosulfan, an organochlorine pesticide; chlorpyrifos, organophosphate insecticide; cypermethrin, type II pyrethroid insecticide, 2,4‐dichlorophenoxyacetic acid, a chlorinated aromatic hydrocarbon acid pesticide) to examine compare their DNA damage in acutely cultured lymphocytes by the comet assay. In addition, possible differences response...
Prostate cancer is the most common type of in males. There has been currently no therapy to cure various types cancer, and hence, studies aiming develop treatment are important have ongoing. Irisin a hormone, which regulates body weight metabolism, including insulin resistance thought beneficial effects on properties antiobesytetic. It known that obesity risk factor development at present time, peptides thay may reduce investigated. This study was carried out investigate whether there role...
Apelin is an adipose tissue derived peptidergic hormone. In this study, 40 male Sprague-Dawley rats were used (four groups; n = 10). Apelin-13 at three different dosages (1, 5 and 50 μg/kg) was given intraperitoneally while the control group received vehicle same route for a period of 14 days. results, apelin-13 caused significant decreases in serum testosterone, luteinizing hormone follicle-stimulating levels (p < 0.05). Administration significantly increased body weights, food intake,...