A5082118209- Ion Channels and Receptors
- Systemic Sclerosis and Related Diseases
- Adipose Tissue and Metabolism
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Inflammasome and immune disorders
- Diet and metabolism studies
- Apelin-related biomedical research
- Magnesium in Health and Disease
- Insect and Pesticide Research
- Migraine and Headache Studies
- Biochemical effects in animals
- Obsessive-Compulsive Spectrum Disorders
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Genetic factors in colorectal cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Myeloid Leukemia Treatments
- Autoimmune Bullous Skin Diseases
- Pediatric health and respiratory diseases
- Folate and B Vitamins Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ion channel regulation and function
- HER2/EGFR in Cancer Research
Fırat University
2015-2024
Adıyaman University
2023
Elazığ Eğitim ve Araştırma Hastanesi
2021-2022
State Hospital
2010
Pediatrics and Genetics
2010
We investigated whether treatment with imidacloprid would induce morphological changes, DNA fragmentation, antioxidant imbalance and apoptosis in the reproductive system of developing male rats. Twenty‐four rats were included this 90‐day study, starting at 7 days age. The divided into four groups. first group was used as control. second, third fourth groups received oral 0.5‐, 2‐ 8‐mg/kg imidacloprid, respectively. Serum, sperm testis samples collected from all end experimental period....
In the current study it was aimed to investigate toxicity of low doses imidacloprid (IMI) on reproductive organ systems adult male rats. The treatment groups received 0.5 (IMI-0.5), 2 (IMI-2) or 8 mg IMI/kg body weight by oral gavage (IMI-8) for three months. deterioration in sperm motility IMI-8 group and epidydimal concentration IMI-2 abnormality morphology were significant. levels testosterone (T) GSH decreased significantly compared control group. Upon with IMI, apoptotic index increased...
Piezo1/2, a mechanically activated ion channel, is believed to play an important role in bladder carcinogenesis process. Piezo1/2 expression has not been previously reported urinary carcinoma, and little known about its significance carcinogenesis.In our study, we aimed evaluate the Piezo1 Piezo2 as developmental mouse tissue cancer of mice humans.The detection was performed on P0-P90 days Balb/c strain mice. Mice were divided into (n = 40) control groups 10). Bladder created by using...
Maternal hyperhomocysteinemia is associated with a number of complications such as preeclampsia syndrome, thromboembolic events, repeated miscarriages, abruptio placentae, in utero fetal death, intrauterine growth restriction and neural tube defects. However, little known about the mechanism homocysteine on degeneration brain. Thus, our study aimed to investigate effects maternal oxidative stress apoptosis pup Hyperhomocysteinemia was induced female rats by way administrating methionine...
Apelin is an adipose tissue derived peptidergic hormone. In this study, 40 male Sprague-Dawley rats were used (four groups; n = 10). Apelin-13 at three different dosages (1, 5 and 50 μg/kg) was given intraperitoneally while the control group received vehicle same route for a period of 14 days. results, apelin-13 caused significant decreases in serum testosterone, luteinizing hormone follicle-stimulating levels (p < 0.05). Administration significantly increased body weights, food intake,...
Background: Cancer is one of the most significant, common, and dangerous diseases our age. Genetic epigenetic factors play an important role in disease process. Three key mechanisms dominate pathogenesis chronic diseases: inflammation, oxidative stress, endothelial dysfunction. The proper functioning these vital for maintaining health. In this context, three micronutrients stand out operating mechanisms. These are vitamins, trace elements minerals. nutrients primarily obtained through...
Clothianidin (CTD) is a novel, broad-spectrum insecticide. In the current study, it was aimed to study effect of subchronic exposure low doses CTD (2, 8 and 24 mg/kg body weight/day) on reproductive system in adult rats. treatment did not significantly change serum testosterone level or sperm parameters (e.g. concentration, motility morphology), but caused significant decreases weights epididymis, right cauda epididymis seminal vesicles. cause DNA fragmentation apoptotic index seminiferous...
Resveratrol, a phytochemical, acts several cellular signaling pathways and has anti-inflammatory potentials. The purpose of this study is to research the therapeutic effect resveratrol in collagen-induced arthritis (CIA) model rats whether affects activities those are potent pathogenic actors rheumatoid arthritis. Arthritis was induced by intradermal injection chicken type II collagen combined with incomplete Freund's adjuvant Wistar albino rats. One day after onset (day 14), (20 mg/kg/day)...
This study was carried out to investigate the effect of semen freeze–thawing process on functionality and molecular structure ram spermatozoa. The temperature pooled diluted at 38°C (group 1, control) lowered 5°C 2), it subjected glycerolisation–equilibration 3), frozen thawed 4). Compared control, deterioration in spermatological parameters significant increases lipid peroxidation global DNA methylation levels were observed groups 3 4. When compared with downregulation miR-485 group 2,...
Abstract In this study, we suggest that chronic maternal hyperhomocysteinemia results in learning deficits the offspring due to delayed brain maturation and altered expression pattern of neural cell adhesion molecule. Although deleterious effects were extensively investigated adults, there is no clear evidence suggesting its action on developing fetal rat cognitive functions offspring. Therefore, present work aimed investigate development behavior A group pregnant rats received daily...
Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is important in the process inflammation fibrosis. The adenosine 5'-monophosphate-activated protein (AMPK) enzyme can affect JAK/STAT pathway. Tofacitinib a pan-JAK inhibitör. Metformin activates AMPK enzyme. We aimed to investigate therapeutic efficacy tofacitinib metformin on IL-17 TGF-β cytokines, skin fibrosis mouse model systemic sclerosis (SSc). 40 Balb/c female mice were divided into 4 groups: (control,...
Abstract Moderate hyperhomocysteinemia is a risk factor for neurodegenerative diseases and complications during pregnancy. Increased homocysteine levels pregnancy may elevate developmental on fetal brain structure function. However, little known about the mechanism of action degeneration brain. Hence in this study, we examined effects maternal oxidative stress apoptosis tissues investigated whether administration melatonin to mother would prevent homocysteine‐induced cerebral damage pups....
Familial Mediterranean Fever (FMF) is an autoinflammatory periodic disorder. We aim to identify the distribution and frequency of (MEFV) gene mutations in east Anatolia Turkey perform a genotype/phenotype correlation patients' cohort. The study was carried out on 415 clinically diagnosed Turkish FMF patients 103 healthy controls. tested individuals were screened for most common twelve MEFV mutations. important features predominance M694V E148Q patient group earlier onset disease mutation...
Objective: To investigate whether m 6 A content changes in type 2 diabetes mellitus (T2DM) and obese individuals the relationship of with mRNA expression levels FTO ALKBH5 genes.
Urinary bladder cancer is one of the most common malignancies urinary tract. Ion channels and calcium homeostasis are involved in almost all basic cellular mechanisms. The transient receptor potential cation channel subfamily M (TRPM) takes its name from melastatin protein, which classified as tumor suppressor. To best our knowledge, there have been no previous studies literature investigating role these ion cancer. present study aimed to determine whether associated with mRNA expression...
Background: Hyperhomocysteinemia (HHcy) is associated with neurodegenerative diseases. Transient receptor potential melastatin (TRPM2) and TRPM7 channels may be activated by oxidative stress. Hydrated C(60) fullerene (C(60)HyFn) have recently gained considerable attention as promising candidates for states. We aimed to examine the effects on TRPM2 gene expression of C(60)HyFn due marked antioxidant activity in HHcy mice. Methods: C57BL/6 J. mice were divided into four groups: (1) Control...