A5002653058- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Systemic Sclerosis and Related Diseases
- MRI in cancer diagnosis
- Medical Imaging and Pathology Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Retinal Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Mast cells and histamine
- Adipose Tissue and Metabolism
- Neuroendocrine Tumor Research Advances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bone and Joint Diseases
- Pleural and Pulmonary Diseases
- Occupational and environmental lung diseases
- Diet and metabolism studies
- Sarcoma Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Apelin-related biomedical research
- Cancer Diagnosis and Treatment
- Skin Diseases and Diabetes
- melanin and skin pigmentation
- Genital Health and Disease
- Adipokines, Inflammation, and Metabolic Diseases
Fırat University
2013-2022
Bakırçay Üniversitesi
2022
Izmir University
2022
Inonu University
2012-2018
Rush University Medical Center
2017
Columbia College - Missouri
2017
Malatya Devlet Hastanesi
2015
Elazığ Eğitim ve Araştırma Hastanesi
2006-2009
University of Florida
2009
Laboratory Imaging (Czechia)
2005
Chronic inflammatory diseases are associated with an accelerated atherosclerotic process. Recent studies have discussed whether bowel (IBDs) can predict early atherosclerosis. We investigated this possibility.The study consisted of IBD cases (group 1, n = 40) and healthy persons 2, 40). The group was selected so as not to vascular disease or the presence established major cardiovascular risk factors.Group 1 showed a significant increase in carotid intima media thickness (cIMT; P .01)....
In the present study, we investigated protective effect of genistein in experimental acute liver damage induced by CCl4.Forty rats were equally allocated to 5 groups. The first group was designated as control (group 1). second injected with intraperitoneal CCl4 for 3 days 2). third subcutaneous 1 mg/kg 4 starting one day before injection. fourth 7 days. fifth 8 Plasma and tissue malondialdehyde (MDA) glutathione levels, well AST ALT levels studied. A histopathological examination...
In the present study, we examined preventive role of epigallocatechin gallate (EGCG) in an experimental non-alcoholic steatohepatitis model induced by a high fat diet.The study included 21 male Sprague-Dawley rats, which were equally divided into three groups. The first group was fed on standard rat diet, second diet (HFD), and third HFD + EGCG. concluded after 6 weeks. Histopathological examination performed. Plasma tissue MDA levels, glucose, insulin, alanine aminotransferase (ALT),...
Heterotopic gastric mucosa (HGM) is found in the cervical oesophagus, just below upper oesophageal sphincter, and has generally been overlooked by endoscopists. The objective of present study to determine endoscopic prevalence histopathological clinical characteristics HGM classify patients according their clinicopathological features.A total 911 consecutive (436 M 475 F) who were admitted our Endoscopy Unit examined. type presence Helicobacter pylori (Hp) either stomach or...
Ghrelin and obestatin are a single gene products multiple functional peptides that regulates energy homeostasis, food intake. In the present work, we studied secretion of ghrelin its co-secreted peptide in 44 patients with ischemic heart disease 27 healthy matched controls. Here first conducted using an immunohistochemistry assay to screen whether human salivary glands have any immunoreactivity. Then, serum saliva acylated levels were determined by Radioimmunoassay. Our immunohistochemical...
Epigallocatechin 3-gallate (EGCG) is a polyphenol that has been shown to have antioxidant and anti-inflammatory effects. In this study, collagen-induced arthritis (CIA) model, in Wistar albino rats, was used elucidate the effect of EGCG on pathogenetic pathways inflammatory arthritis. The levels serum TNF-α, IL-17, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx); expression tissue heme oxygenase-1 (HO-1) nuclear factor erythroid 2-related 2...
Background and objectives: Cytotoxic T-lymphocyte (CTL)-mediated inflammatory response to tumors plays a crucial role in preventing the progression of some cancers. Programmed cell death ligand 1 (PD-L1), cell-surface glycoprotein, has been reported repress T-cell-mediated immune responses against tumors. However, clinical significance PD-L1 colorectal cancer (CRC) remains unclear. Our aim was elucidate prognostic expression CD8+ CTL density CRC. Materials methods: CD8 immunostaining...
Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is important in the process inflammation fibrosis. The adenosine 5'-monophosphate-activated protein (AMPK) enzyme can affect JAK/STAT pathway. Tofacitinib a pan-JAK inhibitör. Metformin activates AMPK enzyme. We aimed to investigate therapeutic efficacy tofacitinib metformin on IL-17 TGF-β cytokines, skin fibrosis mouse model systemic sclerosis (SSc). 40 Balb/c female mice were divided into 4 groups: (control,...
Gastric cancer is one of the foremost causes related death around world. The P2X7 receptor (P2X7R), a member P2X subfamily P2 receptors, unique molecule that has been shown to affect tumor growth and progression as well various inflammatory processes, including proliferation T lymphocytes, release cytokines, production free oxygen radicals. P2X7R established prognostic parameter in some cancers and, recently, it investigated development new targeted therapies. In present study, we aimed...
Ghrelin (G-HH) synthesized in several tissues including salivary and stomach glands stimulates appetite humans by modulating neuropeptide Y neurons the hypothalamic arcuate nucleus. Loss of is one most important symptoms cancer. We conducted a study using immunohistochemistry to determine whether cancer produce ghrelin. determined that negative ghrelin discriminates tumors from normal may therefore further our understanding clinically problem reduced food intake anorexia patients....
Doxorubicin (DOX) is an anthracycline cytotoxic chemotherapeutic drug that commonly used in cancer treatment. A major side effect limiting the clinical use of DOX cardiotoxicity due to oxidative injury. Nigella sativa (NS) annual flowering plant with antioxidant properties. Its seeds contain several bioactive constituents such as saturated and unsaturated fatty acids, thymoquinone, dithymoquinone, thymohydroquinone, thymol. In this study, we investigated NS extract on DOX-induced...
To examine the effectiveness of apparent diffusion coefficient (ADC) values and to compare reliability different b-values in detecting identifying significant liver fibrosis.There were 44 patients with chronic viral hepatitis (CVH) study group 30 healthy participants control group. Diffusion-weighted magnetic resonance imaging (DWI) was performed before biopsy CVH. The ADC measured 3 (100, 600, 1,000 s/mm2). In addition, fibrosis classified using modified Ishak scoring system. Liver stages...
Ghrelin belongs to the family of a gut-brain hormone that promotes food intake and controls energy balance. Recently, it has also been shown regulate bone formation directly. Dental tissue shares several functional, developmental anatomical similarities with bone, in present study we have investigated presence ghrelin 44 human teeth using immunocytochemistry radioimmunoassay. Both methods showed is canines molars, mainly odontoblasts but pulp. could potentially play interesting physiological...
Purpose: The purposes of this study were to investigate the effects topically administrated Tacrolimus and Octreotide on modulation postoperative scarring in experimental glaucoma filtration surgery compare antifibrotic properties these agents with mitomycin-C (MMC).