A5029601006- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Hypothalamic control of reproductive hormones
- Ion Channels and Receptors
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Reproductive biology and impacts on aquatic species
- Pancreatic function and diabetes
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Olfactory and Sensory Function Studies
- Inflammatory Biomarkers in Disease Prognosis
- Dietary Effects on Health
- Cervical Cancer and HPV Research
- Neurobiology and Insect Physiology Research
- Receptor Mechanisms and Signaling
- Blood donation and transfusion practices
- Estrogen and related hormone effects
- Agricultural Practices and Plant Genetics
- Software Engineering Techniques and Practices
- Face recognition and analysis
- Health disparities and outcomes
- Mechanisms of cancer metastasis
Shyam Shah Medical College
2020-2025
University of Michigan
2024
University of Iowa
2018-2024
Yeditepe University
2024
University of Miami
2024
Baylor College of Medicine
2024
ABES Engineering College
2023
Vardhman Mahavir Medical College & Safdarjung Hospital
2023
National Institute of Science Education and Research
2011-2020
New York University
2020
Abstract Norepinephrine (NE) is a well-known appetite regulator, and the nor/adrenergic system targeted by several anti-obesity drugs. To better understand circuitry underlying adrenergic control, here we investigated paraventricular hypothalamic nucleus (PVN), key brain region that integrates energy signals receives dense input, using mouse model. We found PVN NE level increases with of deficit decreases food access. This pattern recapitulated innervating catecholaminergic axon terminals...
Background: Cervical cancer poses a significant public health challenge, emphasizing the need for effective screening strategies early detection. Conventional Pap smear (CPS) has been standard tool decades, while liquid-based cytology (LBC) was developed to overcome its limitations. This study compares efficacy of CPS and LBC in detecting cervical neoplastic lesions. Aims Objectives: To determine compare as tools detection lesions tertiary care setting. Materials Methods: A prospective...
The paraventricular nucleus of hypothalamus (PVN), an integrative center in the brain, orchestrates a wide range physiological and behavioral responses. While PVN melanocortin 4 receptor (MC4R) signaling (PVN
Leptin resistance is a hallmark of obesity with unclear etiology. Celastrol, compound found in the roots Tripterygium wilfordii and known to reduce endoplasmic reticulum (ER) stress, has recently emerged as promising candidate treat by improving leptin sensitivity. However, underlying neural mechanisms which celastrol reduces remain unclear. Using three different mouse models obesity—diet-induced (DIO), receptor (LepR)-null, melanocortin 4 (MC4R)-null mice—in this study, we show that...
Abstract Although the role of alpha‐melanocyte stimulating hormone (α‐ MSH ) in alcohol seeking behaviour rats has been demonstrated, underlying mechanisms are not understood. Herein, we test hypothesis that α‐ might have a permissive effect promoting reward action ethanol. Rats were implanted with cannulae targeted at posterior ventral tegmental area ( pVTA ), because site is sensitive to reinforcing effects These trained self‐administer ethanol standard two‐lever (active/inactive) operant...
Abstract Cocaine‐ and amphetamine‐regulated transcript (CART) has emerged as a potent anorectic agent. CART is widely distributed in the brain of mammals, amphibians, teleosts, but relevant information avian not available. In birds, inhibits food intake, whereas neuropeptide Y (NPY), well‐known orexigenic peptide, stimulates it. How these neuropeptides interact to regulate energy balance known. We studied distribution CART‐immunoreactivity zebra finch, Taeniopygia guttata, its interaction...
Most of the animal studies using inflammation-induced cognitive change have relied on behavioral testing without objective and biologically solid methods to quantify severity disturbances. We developed a bispectral EEG (BSEEG) method novel algorithm in clinical study. This effectively differentiates between patients with delirium, predict long-term mortality. In present study, we aimed apply our method, which can detect mouse model delirium systemic inflammation induced by...
Apart from gonadotrophin‐releasing hormone (GnRH) and dopamine (DA), oxytocin has emerged as an important endogenous agent that regulates reproduction. Although the interaction between these factors been extensively studied in mammals, parallel information teleosts is much limited. We organisation of tyrosine hydroxylase (TH; a marker for dopamine) isotocin neurones preoptic area (POA) hypothalamus catfish, Clarias batrachus its implication regulation luteinising (LH) cells pituitary....
Recent studies suggest an important role for transient receptor potential vanilloid (TRPV) ion channels in neural and neuroendocrine regulation. The TRPV subfamily consists of six members: TRPV1-6. While the neuroanatomical functional correlates TRPV1-4 have been studied extensively, relevant information about TRPV5 TRPV6, which are highly selective Ca2+ , is limited. We detected mRNA expression olfactory bulb, cortex, hypothalamus, hippocampus, midbrain, brainstem cerebellum rat....
RGS2 is a GTPase activating protein that modulates GPCR-G
Dopamine ( DA ) inhibits, whereas gonadotrophin‐releasing hormone (Gn RH) stimulates, luteinisiing LH) cells in the pituitary of some but not all teleosts. A reduction hypophysiotropic dopaminergic tone is necessary for stimulatory effect Gn RH on LH cells. Neuropeptide Y NPY has emerged as one potent, endogenous agent that modulates secretion directly or indirectly via . Involvement regulation neurones, however, known, there good evidence suggesting an interaction mammalian hypothalamus....
Dopamine (DA) neurons in the anteroventral periventricular nucleus (AVPV) preoptic area (POA) of mammals express estrogen receptors, regulate luteinizing hormone (LH) secretion, and show distinct sexual dimorphism. In teleosts, hypophysiotropic DA preopticus periventricularis (NPP), located POA, innervate LH cells, emerged as a neuroanatomical substrate for inhibiting cells. Interestingly, NPP AVPV seem to share several similarities. Whether DAergic dimorphism is, however, not known. Based...
Peptide/protein hormones could be stored as non-toxic amyloid-like structures in pituitary secretory granules. ACTH and β-endorphin are two of the important peptide that get co-stored Here, we study molecular interactions between their colocalization form amyloid aggregates. Although is known to a part ACTH-β-endorphin aggregate, alone cannot aggregate into under various plausible conditions. Using all atom dynamics simulation investigate early interaction events system, β-endorphin-only...
Dopamine ( DA ) has emerged as a potent inhibitory neuromodulator of luteinsing hormone LH) secretion and reproduction in teleosts. The neurones located the anterior subdivision nucleus preopticus periventricularis NPP a) preoptic area POA innervate pituitary gland regulate LH cells. Although reduction ergic tone is crucial for stimulatory action gonadotrophin‐releasing (Gn RH) on cells, role other hypothalamic factors suggested but not fully understood. Nonapeptide, isotocin IST likely...
Hippocampal dysfunction is associated with major depressive disorder, a serious mental illness characterized by not only depressed mood but also appetite disturbance and dysregulated body weight. However, the underlying mechanisms which hippocampal circuits regulate metabolic homeostasis remain incompletely understood. Here we show that collateralizing melanocortin 4 receptor (MC4R) in ventral subiculum (vSUB), one of output structures formation, affect food motivation energy balance....
Background:The aged population is a medical as well sociological problem.It makes very great demand in terms of health services the community. Objectives:The current study was conducted to know important epidemiological determinants affecting mental status geriatric age. Material and Methods:The design non-experimental, analytical cross-sectional comprising 200 participants from rural urban areas.Consent subject regarding their participation obtained.Data entry done excel sheet final...