A5085860724- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Neurobiology and Insect Physiology Research
- Hypothalamic control of reproductive hormones
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Neuropeptides and Animal Physiology
- Ion Channels and Receptors
- Brain Metastases and Treatment
- Head and Neck Cancer Studies
- Neuroendocrine regulation and behavior
- Animal Behavior and Reproduction
- Reproductive biology and impacts on aquatic species
- Animal Vocal Communication and Behavior
- Diabetes and associated disorders
- Lung Cancer Research Studies
- Circadian rhythm and melatonin
- Olfactory and Sensory Function Studies
- Polysaccharides Composition and Applications
- Infrared Thermography in Medicine
- Attention Deficit Hyperactivity Disorder
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Diabetes Management and Education
- Cardiac Health and Mental Health
The University of Texas Southwestern Medical Center
2021-2024
Southwestern Medical Center
2021-2024
National Institute of Science Education and Research
2014-2024
Homi Bhabha National Institute
2016-2024
Uttaranchal University
2023
AMRI Hospitals
2020
Institute of Physics, Bhubaneshwar
2014
Burdwan Medical College & Hospital
2013
Nil Ratan Sircar Medical College and Hospital
2013
The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently identified antagonist and an inverse agonist of the growth secretagogue receptor (GHSR). GHSR's other well-known endogenous ligand, acyl-ghrelin, increases food intake, body weight, GH secretion lowered in obesity but elevated upon fasting. In contrast, LEAP2 reduces acyl-ghrelin-induced intake found Thus, plasma LEAP2/acyl-ghrelin molar ratio could be key determinant modulating GHSR signaling response to changes mass...
The number of individuals affected by metabolic dysfunction associated fatty liver disease [1] is on the rise, yet hormonal contributors to condition remain incompletely described and only a single FDA-approved treatment available. Some studies suggest that hormones ghrelin LEAP2, which act as agonist antagonist/inverse agonist, respectively, for G protein coupled receptor GHSR, may influence development MAFLD. For instance, increases hepatic fat whereas synthetic GHSR antagonists do...
Diabetes mellitus (DM) is a frequently encountered chronic metabolic disease with various complications throughout its course, which causes severe restriction and disability in an individual's life. It has been well documented that the incidence of depression higher diabetic patients co-morbid further deterioration quality life patients.To study prevalence impact on type II DM.Single centre, cross-sectional, single interview.Total 195 DM are included this study. To diagnose Depressive...
Introduction With the revolution in contemporary medicines, medical imaging techniques such as magnetic resonance (MRI), ultrasound, CT scan, etc. have been widely employed for more accurate and precise pathological variations well diagnosis. Medical based diagnosis is nonin
Acyl-ghrelin regulates eating, body weight, blood glucose, and GH secretion upon binding to its receptor GHSR (growth hormone secretagogue receptor; ghrelin receptor). is distributed in several brain regions some peripheral cell-types including pituitary somatotrophs. The objective of the current study was determine functional significance acyl-ghrelin's action on GHSR-expressing somatotrophs mediating metabolic actions. GH-IRES-Cre mice loxP-flanked (floxed) were newly developed then...
Abstract Cocaine‐ and amphetamine‐regulated transcript (CART) has emerged as a potent anorectic agent. CART is widely distributed in the brain of mammals, amphibians, teleosts, but relevant information avian not available. In birds, inhibits food intake, whereas neuropeptide Y (NPY), well‐known orexigenic peptide, stimulates it. How these neuropeptides interact to regulate energy balance known. We studied distribution CART‐immunoreactivity zebra finch, Taeniopygia guttata, its interaction...
Abstract The hormone ghrelin serves a protective role in cancer-related anorexia-cachexia syndrome (CACS) – condition which plasma levels of rise, its administration lessens CACS severity, and experimentally-reduced signaling by receptor (GHSR) worsens fat loss anorexia accelerates death. Yet, actions for the related liver-expressed antimicrobial peptide-2 (LEAP2), is an endogenous GHSR antagonist, are unexplored CACS. Here, we found that LEAP2 LEAP2/ghrelin ratio were lower Lewis Lung...
Dopamine (DA) neurons in the anteroventral periventricular nucleus (AVPV) preoptic area (POA) of mammals express estrogen receptors, regulate luteinizing hormone (LH) secretion, and show distinct sexual dimorphism. In teleosts, hypophysiotropic DA preopticus periventricularis (NPP), located POA, innervate LH cells, emerged as a neuroanatomical substrate for inhibiting cells. Interestingly, NPP AVPV seem to share several similarities. Whether DAergic dimorphism is, however, not known. Based...
Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here, we sought determine whether ghrelin's islets extend the alteration of size and β cell mass. We demonstrate that reducing ghrelin - by gene knockout (GKO), conditional ablation, or high-fat diet (HFD) feeding was associated with increased mean (up 62%), percentage large 854%), cross-sectional area 51%). In GKO mice, these were more apparent in 10- 12-week-old mice than 4-week-old mice. Higher numbers...
Reducing ghrelin by gene knockout (GKO), ghrelin-cell ablation, or high-fat diet feeding increases islet size and β-cell mass in male mice. Here we determined if reducing also enlarges islets females pregnancy-associated changes are related to reduced ghrelin. Islet were larger (P = .057 for mass) female GKO Pregnancy was associated with increased liver-expressed antimicrobial peptide-2 (LEAP2; a receptor antagonist) wild-type Ghrelin deletion pregnancy each (by ∼19.9-30.2% ∼34.9-46.4%,...
Abstract Objective Prader‐Willi syndrome (PWS) is a multisystem genetic disorder. Unfortunately, none of several mouse models carrying PWS mutations emulates the entirety human phenotype, including hyperphagia plus obesity. Methods To determine whether housing at thermoneutrality (TN, 30 °C) permits development and obesity in Snord116del model, effects three different ages wild‐type (WT) littermates TN versus room temperature (RT, 22–24 for 8 weeks were compared. Results mice born maintained...
Replacement of gluten is a challenging issue in preparation the bakery products. The present work aimed to develop gluten-free biscuits by using flours like rice, sorghum, and corn different ratios (0, 25, 33.33, 50, 100%). quality prepared was analyzed based on physical, chemical, nutritional parameters. It found that there significant (p < 0.05) effect flour ratio chemical properties biscuits. Sample with an equal be good terms total sugar, reducing protein content, fat moisture ash some...
Abstract Thyrotropin‐releasing hormone (TRH) regulates the hypothalamic–pituitary–thyroid axis in mammals and also prolactin secretion, directly or indirectly via tuberoinfundibular dopamine neurons. Although TRH is abundantly expressed teleost brain believed to mediate neuronal communication, empirical evidence lacking. We analyzed pro‐TRH‐mRNA expression, mapped TRH‐immunoreactive elements pituitary, explored its role regulation of hypophysiotropic (DA) neurons catfish, Clarias batrachus ....
Dopamine ( DA ) has emerged as a potent inhibitory neuromodulator of luteinsing hormone LH) secretion and reproduction in teleosts. The neurones located the anterior subdivision nucleus preopticus periventricularis NPP a) preoptic area POA innervate pituitary gland regulate LH cells. Although reduction ergic tone is crucial for stimulatory action gonadotrophin‐releasing (Gn RH) on cells, role other hypothalamic factors suggested but not fully understood. Nonapeptide, isotocin IST likely...
Previous studies have implicated the orexigenic hormone ghrelin as a mediator of exercise endurance and feeding response postexercise. Specifically, plasma levels nearly double in mice when they are subjected to an hour-long bout high-intensity interval (HIIE) using treadmills. Also, growth secretagogue receptor-null (GHSR-null) exhibit decreased food intake following HIIE diminished running distance (time until exhaustion) during longer, stepwise protocol. To investigate whether...
Abstract Secretagogin (scgn), is a novel hexa EF‐hand, phylogenetically conserved calcium‐binding protein. It serves as Ca 2+ sensor and participates in ‐signaling neuroendocrine regulation mammals. However, its relevance the brain of non‐mammalian vertebrates has largely remained unexplored. To address this issue, we studied cDNA encoding scgn, scgn mRNA expression, distribution scgn‐equipped elements pituitary teleost, Clarias batrachus ( cb ). The cbscgn consists three transcripts (T)...