A5011531942- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Memory and Neural Mechanisms
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Neurogenesis and neuroplasticity mechanisms
- Photoreceptor and optogenetics research
- Tryptophan and brain disorders
- Epilepsy research and treatment
- Neurological disorders and treatments
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Parkinson's Disease Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- melanin and skin pigmentation
- Axon Guidance and Neuronal Signaling
- Circadian rhythm and melatonin
- Traumatic Brain Injury Research
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Amino Acid Enzymes and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
Texas A&M University
2024-2025
Creighton University
2018-2023
University of Copenhagen
2019
Rashtrasant Tukadoji Maharaj Nagpur University
2011-2017
Hindu College of Pharmacy
2010
Abstract Ionotropic glutamate receptors (iGluRs) mediate fast excitatory neurotransmission in the nervous system. In addition to NMDA receptor co-agonists, D-serine is a ligand for delta (GluDs) and interacts with ligand-binding domain low affinity. However, binding does not lead typical ion channel currents GluD1 or GluD2 but may contribute synaptic plasticity. developing brain, facilitates long-term depression at parallel fiber-Purkinje cell synapses. influence of on GluD1's interaction...
Impaired behavioral flexibility and repetitive behavior is a common phenotype in autism other neuropsychiatric disorders, but the underlying synaptic mechanisms are poorly understood. The trans-synaptic glutamate delta (GluD)-Cerebellin 1-Neurexin complex, critical for synapse formation/maintenance, represents vulnerable axis diseases. We have previously found that GluD1 deletion results reversal learning deficit behavior. In this study, we show selective ablation of from dorsal striatum...
Cocaine-associated memories induce cravings and interfere with the ability of users to cease cocaine use. Reducing strength cue-drug by facilitating extinction may have therapeutic value for treatment addiction. Here, we demonstrate expression GluN1/2A/2C NMDA receptor currents in astrocytes nucleus accumbens core. Selective ablation GluN1 subunit from enhanced preference memory but did not affect conditioning or reinstatement. Repeated exposure up-regulated GluN2C increased astrocytic...
Abstract Although the role of alpha‐melanocyte stimulating hormone (α‐ MSH ) in alcohol seeking behaviour rats has been demonstrated, underlying mechanisms are not understood. Herein, we test hypothesis that α‐ might have a permissive effect promoting reward action ethanol. Rats were implanted with cannulae targeted at posterior ventral tegmental area ( pVTA ), because site is sensitive to reinforcing effects These trained self‐administer ethanol standard two‐lever (active/inactive) operant...
Globus pallidus externa (GPe) is a nucleus in the basal ganglia circuitry involved control of movement. Recent studies have demonstrated critical role GPe cell types Parkinsonism. Specifically increasing function parvalbumin (PV) neurons has been found to facilitate motor mouse model Parkinson's disease (PD). The knowledge contribution NMDA receptors limited. Here, we demonstrate that fast spiking express receptor currents sensitive GluN2C/GluN2D-selective inhibitors and glycine site agonist...
The GluN2C- and GluN2D-containing NMDA receptors are distinct from GluN2A- GluN2B-containing in many aspects including lower sensitivity to Mg2+ block lack of desensitization. Recent studies have highlighted the unique contribution GluN2C GluN2D subunits various neuronal circuit function behavior, however a direct comparison effect ablation these mice on pure background strain has not been conducted. Using knockout-first strains for GRIN2C GRIN2D produced C57BL/6N strain, we compared partial...
The GluN2C subunit of the NMDA receptor is enriched in neurons nucleus reticularis thalamus (nRT), but its role regulating their function not well understood. We found that deletion did affect spike frequency response to depolarizing current injection or hyperpolarization-induced rebound burst firing nRT neurons. d-Cycloserine CIQ (GluN2C/GluN2D positive allosteric modulator) depolarization-induced A newly identified highly potent and efficacious coagonist GluN1/GluN2C receptors, AICP...
Enhancement of N-methyl-D-aspartate (NMDA) receptor function using glycine-site agonist D-cycloserine is known to facilitate fear extinction, providing a means augment cognitive behavioral therapy in anxiety disorders. A novel class agonists has recently been identified, and we have found that the prototype, AICP, more effective than modulating neuronal function.Using local infusion studies, genetic models, elucidated role GluN2C-containing receptors extinction.We tested effect...
Although modulatory effects of neuropeptide Y (NPY) on ethanol consumption are well established, its role in reward, the framework mesolimbic dopaminergic system, has not been studied. We investigated influence nucleus accumbens shell (AcbSh) NPYergic system self-administration posterior ventral tegmental area (p-VTA) using intracranial paradigm. Rats were stereotaxically implanted with cannulae targeted unilaterally at right p-VTA and trained to self-administer (200 mg%) standard two-lever...
Abstract Although dysregulation of the dopaminergic mesolimbic system is generally considered central to addiction, involvement other circuits increasingly being appreciated. An interaction between locus coeruleus (LC) noradrenergic neurons and posterior ventral tegmental area (pVTA) system, in processing drug‐triggered reward, has been suggested, but not demonstrated behaving animals. Herein, we try tease out precise role LC–VTA circuit mediating reward reinforcement behavior associated...
Abstract Cocaine exposure induces plasticity of glutamatergic synapses medium spiny neurons (MSNs) in the nucleus accumbens (NAc), which has been proposed to contribute its addictive behavior. The mechanisms underlying cocaine-induced are not fully understood. orphan glutamate delta-1 (GluD1) receptor is a member ionotropic family but does function as typical ligand-gated ion channel. Instead it serves synaptogenic by interacting with presynaptic Neurexin protein. Recent neuroanatomical...
Chronic pain is a debilitating condition involving neuronal dysfunction, but the synaptic mechanisms underlying persistence of are still poorly understood. We found that organizer glutamate delta 1 receptor (GluD1) expressed postsynaptically at parabrachio-central laterocapsular amygdala (PB-CeLC) glutamatergic synapses axo-somatic and punctate locations on protein kinase C δ -positive (PKCδ+) neurons. Deletion GluD1 impairs excitatory neurotransmission PB-CeLC synapses. In inflammatory...
Thalamic regulation of cortical function is important for several behavioral aspects including attention and sensorimotor control. This region has also been studied its involvement in seizure activity. Among the NMDA receptor subunits GluN2C GluN2D are particularly enriched thalamic nuclei nucleus reticularis thalamus (nRT). We have previously found that deletion does not a strong influence on basal excitability burst firing characteristics reticular neurons. Here we find ablation leads to...