A5067663462- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Amino Acid Enzymes and Metabolism
- Thyroid and Parathyroid Surgery
- Tryptophan and brain disorders
- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
Texas A&M University
2025
Creighton University
2023
Sir Sayajirao General Hospital Medical College
1981
Abstract Ionotropic glutamate receptors (iGluRs) mediate fast excitatory neurotransmission in the nervous system. In addition to NMDA receptor co-agonists, D-serine is a ligand for delta (GluDs) and interacts with ligand-binding domain low affinity. However, binding does not lead typical ion channel currents GluD1 or GluD2 but may contribute synaptic plasticity. developing brain, facilitates long-term depression at parallel fiber-Purkinje cell synapses. influence of on GluD1's interaction...
Chronic pain remains a major clinical problem that needs effective therapeutic agents. Glutamate delta 1 (GluD1) receptors and the protein cerebellin (Cbln1) are down-regulated in central amygdala (CeA) models of inflammatory neuropathic pain. One treatment with Cbln1, intracerebroventricularly (ICV) or CeA, normalized GluD1 reduced AMPA receptor expression, resulting lasting (7-10 days) relief. Unlike many CNS-targeting biological agents, structure Cbln1 suggests potential blood-brain...
Background and Purpose: Chronic pain remains a major clinical problem there is critical need to develop effective therapeutics. We recently demonstrated that glutamate delta 1 receptor (GluD1) cerebellin (Cbln1) are downregulated in the central amygdala (CeA) inflammatory neuropathic pain. Importantly, we found administering Cbln1 intracerebroventricularly (ICV) or CeA once, normalizes GluD1 reduces AMPA expression resulting lasting (7-10 days) relief. Unlike many CNS-targeting biologics,...