A5091506481- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Intensive Care Unit Cognitive Disorders
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Sedative Agents
- Heart Rate Variability and Autonomic Control
- Optical Imaging and Spectroscopy Techniques
- Treatment of Major Depression
- Schizophrenia research and treatment
- Mental Health Research Topics
- Genetic Neurodegenerative Diseases
- Adipose Tissue and Metabolism
- EEG and Brain-Computer Interfaces
- Psychosomatic Disorders and Their Treatments
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Family and Patient Care in Intensive Care Units
- Neurological disorders and treatments
- Neurogenesis and neuroplasticity mechanisms
- Sleep and related disorders
- Bipolar Disorder and Treatment
Tottori University
2016-2025
Yale University
2010-2015
Antidepressant Action of Ketamine In contrast to the weeks or months treatment required for standard antidepressant medication, ketamine administration produces an response within 4 6 hours in depressed patients. What lies behind rapid actions ketamine? Li et al. (p. 959 ; see Perspective by Cryan and O'Leary ) found that resulted fast activation mammalian target rapamycin (mTOR) signaling increased levels synaptic proteins rat prefrontal cortex. rapidly density function dendritic spines...
Neuro-inflammation has been shown to play a critical role in the development of depression. Beta-hydroxybutyrate (BHB) is ketone body and recently reported exert anti-inflammatory effects via inhibition NLRP3 inflammasome. Here, we investigated potential antidepressant BHB on rats exposed acute chronic stress. We examined influence repeated administration depressive anxiety behaviors rodent model unpredictable stress (CUS). Additionally, immobilization (IMM) single hippocampal interleukin-1β...
Abstract Rats exposed to learned helplessness (LH), an animal model of depression, showed a recovery following intracerebroventricular injection nor‐binaltorphimine dihydrochloride (norBNI; κ‐opioid antagonist). To investigate the potential role dynorphin A and B, we examined effects different stress/depression models on B immunoreactivity in hippocampus nucleus accumbens (NAc). Immobilization stress (3 h) caused increase levels NAc. Forced swim also temporally increased hippocampus....
Aim Although treatment guidelines for pharmacological therapy schizophrenia and major depressive disorder have been issued by the Japanese Societies of Neuropsychopharmacology Mood Disorders, these not well applied psychiatrists throughout nation. To address this issue, we developed ‘Effectiveness Guidelines Dissemination Education in Psychiatric Treatment (EGUIDE)’ integrated education programs to disseminate clinical guidelines. Additionally, conducted a systematic efficacy evaluation...
Inflammation is believed to contribute the pathophysiology of depression, with increased levels inflammatory cytokines, such as interleukin-1β (IL-1β), observed in patients. Depression also common individuals chronic diseases. IL-1β disrupts synaptic transmission and reduces neurogenesis hippocampus, playing a crucial role depression development. Our prior research found that stress activates microglia brain produce via nucleotide-binding oligomerization domain-like receptor family pyrin...
Abstract Aims Neuroinflammation is deeply related to the pathophysiology of depression. Beta‐hydroxybutyrate (BHB), which an endogenous ketone body, exerts anti‐inflammatory effects, and peripheral administration BHB induces antidepressant effects in animal model depression; however, it unclear whether specifically mediates these actions brain. Thus, we administered directly into brain a rodent depression using chronic unpredictable stress (CUS) paradigm. Methods was continuously...
Accumulating evidence suggests that elevated inflammation contributes to the pathophysiology of post-traumatic stress disorder (PTSD) and anti-inflammatory drugs might be a new treatment strategy for PTSD. It has been reported beta-hydroxybutyrate (BHB), one main ketone bodies produced, can have an antidepressant effect. Here, we investigated potential anti-anxiety effects BHB using rodent PTSD model, induced by single prolonged (SPS). Male, Sprague-Dawley rats were employed in this study....
Abstract A couple of papers indicate that patients with depression show a decrease in serum neuropeptide Y (NPY). To study the role NPY depression, we examined effects infusion into hippocampus learned helplessness (LH) rats (an animal model depression). Infusion cerebral ventricle LH showed antidepressant‐like effects. CA3 region, but not dentate gyrus (DG), produced paradigm. did affect locomotor activity or aversive learning ability. Coadministration BIBO3304 (a Y1 receptor antagonist) to...
The astrocyte is a major component of the neural network and plays role in brain function. Previous studies demonstrated changes number astrocytes depression. In this study, we examined alterations learned helplessness (LH) rat, an animal model numbers activated nonactivated dentate gyrus (molecular layer, subgranular zone, hilus), CA1 CA3 regions hippocampus were significantly increased 2 8 days after attainment LH. Subchronic treatment with imipramine showed tendency (although not...
Abstract Current methods for screening and detecting delirium are not practical in clinical settings. We previously showed that a simplified EEG with bispectral electroencephalography (BSEEG) algorithm can detect elderly inpatients. In this study, we performed post-hoc BSEEG data analysis using larger sample size topological to improve the method. Data from 274 subjects included previous study were analyzed as 1st cohort. Subjects enrolled at University of Iowa Hospitals Clinics (UIHC)...
Background We have developed the bispectral electroencephalography (BSEEG) method for detection of delirium and prediction poor outcomes. Aims To improve BSEEG by introducing a new EEG device. Method In prospective cohort study, data were obtained scores calculated. filtered on basis standard deviation (s.d.) values to exclude signals with high noise. Both non-filtered s.d.-filtered analysed. compared results three screening scales: Confusion Assessment Intensive Care Unit (CAM-ICU),...
Most of the animal studies using inflammation-induced cognitive change have relied on behavioral testing without objective and biologically solid methods to quantify severity disturbances. We developed a bispectral EEG (BSEEG) method novel algorithm in clinical study. This effectively differentiates between patients with delirium, predict long-term mortality. In present study, we aimed apply our method, which can detect mouse model delirium systemic inflammation induced by...
Delirium, a syndrome characterized by an acute change in attention, awareness, and cognition, is commonly observed older adults, although there are few quantitative monitoring methods the clinical setting. We developed bispectral electroencephalography (BSEEG) method capable of detecting delirium can quantify severity using novel algorithm. Preclinical application this BSEEG capture delirium-like state mice following lipopolysaccharide administration. However, its to postoperative (POD) has...
Delirium is risky and indicates poor outcomes for patients. Therefore, it crucial to create an effective delirium detection method. However, the epigenetic pathophysiology of remains largely unknown. We aimed discover reliable replicable (DNA methylation: DNAm) markers that are associated with including post-operative (POD) in blood obtained from patients among four independent cohorts. Blood DNA cohorts (two inpatient two surgery cohorts; 16 88 each) were analyzed using Illumina EPIC array...