A5100603563- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Treatment of Major Depression
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Insect and Pesticide Research
- Plant and animal studies
- Axon Guidance and Neuronal Signaling
- Nuclear Receptors and Signaling
- Nicotinic Acetylcholine Receptors Study
- Visual perception and processing mechanisms
- Insect and Arachnid Ecology and Behavior
- Biofield Effects and Biophysics
- Biochemical Analysis and Sensing Techniques
- Stress Responses and Cortisol
- Cholinesterase and Neurodegenerative Diseases
- Bee Products Chemical Analysis
- Receptor Mechanisms and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Neurobiology and Insect Physiology Research
- Cancer, Stress, Anesthesia, and Immune Response
- Viral Infections and Immunology Research
- Balance, Gait, and Falls Prevention
- Carbohydrate Chemistry and Synthesis
- Apelin-related biomedical research
Shenzhen Second People's Hospital
2025
Yangzhou University
2021-2025
Zhengzhou University
2013-2024
Yale University
2007-2023
Sichuan Academy of Traditional Chinese Medicine
2021
Sumitomo Dainippon Pharma (Japan)
2019
Kanazawa University
2019
Guangdong Ocean University
2017
Affiliated Hospital of Qingdao University
2016
Qingdao University
2016
Antidepressant Action of Ketamine In contrast to the weeks or months treatment required for standard antidepressant medication, ketamine administration produces an response within 4 6 hours in depressed patients. What lies behind rapid actions ketamine? Li et al. (p. 959 ; see Perspective by Cryan and O'Leary ) found that resulted fast activation mammalian target rapamycin (mTOR) signaling increased levels synaptic proteins rat prefrontal cortex. rapidly density function dendritic spines...
A single subanesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients, addressing a major unmet need for the treatment mood disorders. Ketamine increase extracellular glutamate synaptic formation prefrontal cortex, but initial cellular trigger that initiates this ketamine's behavioral has not been identified. To address question, we used combination viral shRNA conditional mutation to produce cell-specific...
Ketamine, a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, produces rapid and long-lasting antidepressant effects in major depressive disorder (MDD) patients. (2R,6R)-Hydroxynorketamine [(2R,6R)-HNK], metabolite of ketamine, is reported to produce rodent models without the side ketamine. Importantly, (2R,6R)-HNK does not block NMDA receptors like molecular signaling mechanisms for remain unknown. Here, we examined involvement BDNF/TrkB/mechanistic target rapamycin complex 1...
Objective: The N-methyl-d-aspartate receptor antagonist ketamine produces rapid and sustained antidepressant actions even in patients with treatment-resistant depression. Vascular endothelial growth factor (VEGF) has been implicated the effects of conventional monoamine-based antidepressants, but role VEGF remains unclear. authors examined whether neuronal signaling medial prefrontal cortex (mPFC) mediates ketamine. Methods: used a combination approaches, including conditional,...
This study aimed to address the need for effective probiotics and antibacterial agents combat American foulbrood disease in honeybees, caused by Paenibacillus larvae. In context of declining honeybee populations due pathogens, we isolated eight lactic acid bacteria (LAB) strains from larvae (Apis mellifera L.) evaluated their probiotic potential inhibitory effects against P. Methods included property assessments, such as bile salt resistance, hydrophobicity, auto-aggregation, co-aggregation...
Abstract American foulbrood (AFB) disease, caused by the bacterium Paenibacillus larvae , is a devastating disease affecting honeybee ( Apis mellifera L.) populations worldwide. Commonly treated with antibiotics, which have negative impacts on both honeybees and environment, there an urgent need for alternatives in AFB control. This study aimed to investigate effects of gallic acid (GA) challenged P . spores explore its modulation larval microbiota. Our results demonstrated that presence...
Abstract Nanozymes based on metals have been regarded as a promising candidate in the metabolic reprogramming of low-survival, refractory glioblastoma multiforme (GBM). However, due to size limitations, nanozymes struggle balance catalytic activity with ability cross blood-brain barrier (BBB), limiting their efficiency GBM therapy. Herein, we establish hybrid clustered nanozyme (AM NCs) by cross-linking ultrasmall nano-gold (Au) and manganese oxide (MnO2), which overcomes requirement...
American foulbrood (AFB) disease and chalkbrood (CBD) are important bacterial fungal diseases, respectively, that affect honeybee broods. Exposure to agrochemicals is an abiotic stressor potentially weakens colonies. Gut microflora alterations in adult honeybees associated with these biotic factors have been investigated. However, microbial compositions AFB- CBD-infected larvae the profile of whole-body microbiota foraging bees exposed not fully studied. In this study, communities healthy...
Non-alcoholic steatohepatitis (NASH) is a prevalent chronic liver disease that lacks effective treatment. In this study, the anti-NASH effects of four flavonoids (pinocembrin, galangin, chrysin, and naringenin) rich in propolis were investigated an vitro NASH model established free fatty acids (FFAs)-stimulated HepG2 cells. Using co-treatment approach, our results showed naringenin possessed strongest efficacy by significantly counteracting FFAs-induced lipid accumulation, oxidative...
The excessive activation of the <i>N</i>-methyl-d-aspartate receptor (NMDAR)/nitric oxide (NO) pathway has been proposed to be involved in neuropathology various neurodegenerative disorders. In this study, NO was found mediate glutamate-induced excitotoxicity primary cultured neurons. Compared with synthase (NOS) inhibitor, <i>N</i><sup>G</sup>-monomethyl-l-arginine (l-NMMA), and NMDAR antagonist memantine, bis(7)-tacrine more potent reducing NO-mediated release caused by glutamate....
Currently, qigong and tai chi exercises are the two most common preventive as well therapeutic interventions for chronic metabolic diseases such type 2 diabetes mellitus (T2DM). However, quantitative evaluation of these is limited. This study aimed to evaluate efficacy intervention in middle-aged older adults with T2DM. The included 103 eligible participants, who were randomized participate 12 weeks, one following groups treatment T2DM: fitness qigong, chi, control group. Three biochemical...
Prompted by the near infrared-absorbing properties of some azulenic bacteriorhodopsin (bR) analogs, we have analyzed their absorption characteristics along with 11 new related ring-fused analogs and corresponding Schiff bases (SB) protonated (PSB). The following three factors are believed to contribute total red shift each pigment (sigma RS): perturbation basic chromophore (SB shift, delta SB), protonation SB (PSB PSBS) protein (the opsin OS). For factor, effects structural modifications...
Here we report that bis(7)-tacrine, a novel acetylcholinesterase inhibitor, exerts neuroprotective effects by inhibition of nitric oxide synthase. In cortical neurons at 12 days in vitro, bis(7)-tacrine concentration-dependently reduced cell death induced glutamate, beta-amyloid and L-arginine, but not sodium nitroprusside. N-monomethyl-L-arginine, synthase also prevented the former three types last type cytotoxicity; however, scavengers blocked all these insults, indicating mediated...