A5004477208- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Treatment of Major Depression
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Cholinesterase and Neurodegenerative Diseases
- Adipose Tissue and Metabolism
- Nerve injury and regeneration
- Anesthesia and Neurotoxicity Research
- Chemical synthesis and alkaloids
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Pharmacological Receptor Mechanisms and Effects
- Health, Environment, Cognitive Aging
- Neuropeptides and Animal Physiology
- Axon Guidance and Neuronal Signaling
- Ion channel regulation and function
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Hormonal Regulation and Hypertension
- Mental Health Research Topics
- Genetics, Aging, and Longevity in Model Organisms
Campo Arqueologico de Mertola
2018-2024
Centre for Addiction and Mental Health
2017-2024
University of Toronto
2017-2024
Yale University
2009-2023
Mental Health Research Institute
2021-2023
Mental Health Research Canada
2017-2023
Semmelweis University
2017
Gedeon Richter (Hungary)
2017
Allergan (United States)
2017
Institute of Cognitive Neuroscience and Psychology
2017
Antidepressant Action of Ketamine In contrast to the weeks or months treatment required for standard antidepressant medication, ketamine administration produces an response within 4 6 hours in depressed patients. What lies behind rapid actions ketamine? Li et al. (p. 959 ; see Perspective by Cryan and O'Leary ) found that resulted fast activation mammalian target rapamycin (mTOR) signaling increased levels synaptic proteins rat prefrontal cortex. rapidly density function dendritic spines...
Background:Recent studies demonstrate that the rapid antidepressant ketamine increases spine number and function in medial prefrontal cortex (mPFC), these effects are dependent on activation of glutamate α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors brain-derived neurotrophic factor (BDNF). In vitro also show AMPA stimulates BNDF release via L-type voltage-dependent calcium channels (VDCC).
Major depressive disorder (MDD) has been linked to changes in function and activity of the hippocampus, one central limbic regions involved regulation emotions mood. The exact cellular molecular mechanisms underlying hippocampal plasticity response stress are yet be fully characterized. In this study, we examined genetic profile micro-dissected subfields post-mortem hippocampus from subjects diagnosed with MDD comparison matched for sex, race age. Gene expression profiles dentate gyrus CA1...
Characterizing the mechanisms by which endogenous factors stimulate neurogenesis is of special interest in view possible implication newly generated cells hippocampal functions or disorders. The aim this study was to determine whether serotonin (5-HT) and oestradiol (E2) act through a common pathway increase cell proliferation adult dentate gyrus (DG). We also investigated effects long-lasting changes oestrogen levels on proliferation. Combining ovariectomy with inhibition 5-HT synthesis...
Significance Tic disorders, such as Tourette syndrome, are common but poorly understood. Postmortem studies have revealed the loss of a particular subset neurons, large cholinergic interneurons, in caudate and putamen severe disease. To test whether this neuronal leads to disease we turned mice, where questions causality more readily addressed. We developed strategy for targeted ablation these interneurons. Their disrupting dorsolateral striatum—roughly analogous putamen—produced abnormal...
Background Evidence continues to build suggesting that the GABAergic neurotransmitter system is altered in brains of patients with major depressive disorder. However, there little information available related extent these changes or potential mechanisms associated alterations. As stress a well-established precipitant episodes, we sought explore impact chronic on interneurons. Methods Using western blot analyses and quantitative real-time polymerase chain reaction, assessed effects...