A5012340276- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Memory and Neural Mechanisms
- Autism Spectrum Disorder Research
- Nuclear Receptors and Signaling
- Mental Health Research Topics
- Neurogenesis and neuroplasticity mechanisms
- Histone Deacetylase Inhibitors Research
- Anesthesia and Neurotoxicity Research
- Diet and metabolism studies
- Genetics and Neurodevelopmental Disorders
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Resilience and Mental Health
- Nerve injury and regeneration
- Functional Brain Connectivity Studies
- Educational Methods and Impacts
- Suicide and Self-Harm Studies
- Mindfulness and Compassion Interventions
- Islamic Finance and Communication
- Receptor Mechanisms and Signaling
- Child and Adolescent Psychosocial and Emotional Development
Hiroshima University
2011-2024
Psychiatry Research Trust
2018
Strong Memorial Hospital
2018
University of Rochester
2018
Greater Manchester Mental Health NHS Foundation Trust
2018
University of Manchester
2018
Moscow Research and Clinical Center for Neuropsychiatry
2018
Johns Hopkins University
2018
NewYork–Presbyterian Hospital
2018
Cornell University
2018
Major depression, because of its recurring and life-threatening nature, is one the top 10 diseases for global disease burden. depression still diagnosed on basis clinical symptoms in patients. The search specific biological markers great importance to advance method diagnosis depression. We examined methylation profile 2 CpG islands (I IV) at promoters brain-derived neurotrophic factor (BDNF) gene, which well known be involved pathophysiology analyzed genomic DNA from peripheral blood 20...
Background:Recent studies demonstrate that the rapid antidepressant ketamine increases spine number and function in medial prefrontal cortex (mPFC), these effects are dependent on activation of glutamate α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors brain-derived neurotrophic factor (BDNF). In vitro also show AMPA stimulates BNDF release via L-type voltage-dependent calcium channels (VDCC).
Significance Clinical studies report that a single, low dose of ketamine produces rapid antidepressant response in treatment-resistant depressed patients. Although rodent have begun to elucidate the molecular mechanisms underlying behavioral actions ketamine, brain regions and cellular not been defined. Using combination pharmacological silencing optogenetic stimulation approaches, results current study demonstrate infusion or infalimbic prefrontal cortex synaptic responses similar systemic...
Decreased levels of brain-derived neurotrophic factor (BDNF) in the hippocampus are implicated pathophysiology major depression, although mechanism has yet to be characterized. Epigenetic studies revealed that DNA methylation and histone modifications at promoter exons BDNF gene pivotal factors regulation transcription. Histone acetylation regulates transcription through chromatin remodelling. We examined influence a single immobilization stress (SIS) 2 h 24 afterwards on total mRNA with...
Objectives. Epigenetic mechanisms, such as changes in gene expression resulting from chromatin remodeling through histone acetylation, have been implicated the pathophysiology of depression. However, antidepressant-like effect deacetylase inhibitor sodium butyrate (SB) has inconclusive. The aim this study was to examine SB and elucidate its molecular mechanisms. Methods. We examined a forced swim test (FST) tail suspension (TST). Hippocampal analyses using DNA microarray real-time PCR were...
Neuronal plasticity induced by changes in synaptic morphology and function is well known to play a pivotal role leaning memory as adaptation stress. It suggested that these plastic are due orchestration of alterations gene expression the brain. Recent advances molecular biology have provided evidence epigenetic mechanisms, such DNA methylation histone modification, crucial transcription mammalian Our research group has recently investigated involvement actylation at promoter brain-derived...
Aberrant DNA methylation in the blood of patients with major depressive disorder (MDD) has been reported several previous studies. However, no comprehensive studies using medication-free subjects MDD have conducted. Furthermore, majority these limited to analysis CpG sites islands (CGIs) gene promoter regions. The main aim present study is identify markers that distinguish from non-psychiatric controls. Genome-wide profiling peripheral leukocytes was conducted two set samples, a discovery...
Abstract Since optimal treatment at an early stage leads to remission of symptoms and recovery function, putative biomarkers leading diagnosis prediction therapeutic responses are desired. The current study aimed use a metabolomic approach extract metabolites involved in both the major depressive disorder (MDD) response for escitalopram. We compared plasma MDD patients (n = 88) with those healthy participants found significant differences concentrations 20 metabolites. measured Hamilton...
Abstract Electroconvulsive therapy is the most effective treatment for antidepressant-resistant depression, although its mechanism has not been fully elucidated. Previous studies have demonstrated that electroconvulsive seizures (ECS) induce expression of brain-derived neurotrophic factor (BDNF) in rat hippocampus. However, contrast with mature BDNF (mBDNF) known to antidepressant effects, precursor (pro-BDNF) harmful effects on neurons. We therefore hypothesized efficient processing...
Impaired fear memory extinction (Ext) is one of the hallmark symptoms post‐traumatic stress disorder (PTSD). However, since precise mechanism impaired Ext remains unknown, effective interventions have not yet been established. Recently, hippocampal‐prefrontal brain‐derived neurotrophic factor (BDNF) activity was shown to be crucial for in naïve rats. We therefore examined whether decreased BDNF also involved rats subjected a single prolonged (SPS) as model PTSD. levels were measured by...
Cryopreservation of whole blood is useful for DNA collection, and clinical basic research. Blood samples in ethylenediaminetetraacetic acid disodium salt (EDTA) tubes stored at - 80 °C are suitable extraction, but not high-quality RNA extraction. Herein, a new methodology extraction from human described. Quickly thawing frozen on aluminum blocks room temperature could minimize degradation, improve yield quality compared with the 37 water bath. Furthermore, use NucleoSpin kit increased by...
To establish treatment response biomarkers that reflect the pathophysiology of depression, it is important to use an integrated set features. This study aimed determine relationship between regional brain activity at rest and blood metabolites related escitalopram identify characteristics depression respond treatment.
Abstract Numerous studies have demonstrated that early adverse experiences are associated with the development of susceptibility to stress later in life. Although it is known experience adversity, such as neonatal isolation, maternal separation, and low care, enhances activity hypothalamo‐pituitary‐adrenalaxis rodents, detailed mechanism underlying induced by adversity remains be elucidated. Since neurotrophins been shown a neuroprotective effect, we examined influence repeated isolation on...
Brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of psychiatric disorders adults and elderly individuals, as a result, DNA methylation (DNAm) BDNF gene peripheral tissues including blood has been extensively examined to develop useful biomarker for disorders. However, studies date have not previously investigated effect age on DNAm blood. In this context, we measured 39 CpG units island at promoter exon I gene.We analyzed genomic from 105 health Japanese women 20...