A5084014512- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Pancreatic function and diabetes
- Cellular transport and secretion
- Genetic Neurodegenerative Diseases
- Mechanisms of cancer metastasis
- Endoplasmic Reticulum Stress and Disease
- Neuropeptides and Animal Physiology
- Anesthesia and Neurotoxicity Research
- Toxoplasma gondii Research Studies
- Neurotransmitter Receptor Influence on Behavior
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Islamic Finance and Communication
- Autism Spectrum Disorder Research
- Mast cells and histamine
- Autophagy in Disease and Therapy
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
Hiroshima University
2011-2024
Impaired fear memory extinction (Ext) is one of the hallmark symptoms post‐traumatic stress disorder (PTSD). However, since precise mechanism impaired Ext remains unknown, effective interventions have not yet been established. Recently, hippocampal‐prefrontal brain‐derived neurotrophic factor (BDNF) activity was shown to be crucial for in naïve rats. We therefore examined whether decreased BDNF also involved rats subjected a single prolonged (SPS) as model PTSD. levels were measured by...
G-protein-coupled receptor (GPR) 3 is a member of the GPR family that constitutively activates adenylate cyclase. We have reported expression GPR3 in cerebellar granular neurons (CGNs) contributes to neurite outgrowth and modulates neuronal proliferation survival. To further identify its role, we analyzed precise distribution local functions neurons. The fluorescently tagged protein was distributed plasma membrane, Golgi body, endosomes. In addition, revealed membrane functionally...
Hironori Kobayashi, Manabu Fuchikami, Kenichi Oga, Tatsuhiro Miyagi, Sho Fujita, Satoshi Okada, Yasumasa Okamoto, Shigeru Morinobu. Clin Psychopharmacol Neurosci -0001;0:. https://doi.org/10.9758/cpn.23.1140
Since the precise mechanisms of posttraumatic stress disorder (PTSD) remain unknown, effective treatment interventions have not yet been established. Impaired extinction fear memory (EFM) is one core symptoms PTSD and associated with stress-induced epigenetic change in gene expression.
G protein-coupled receptor 3 (GPR3) is a member of the class A rhodopsin-type GPCR family and highly expressed in various neurons. GPR3 unique its ability to constitutively activate Gαs protein without addition ligands, which elevates basal level intracellular cAMP. We have previously reported that neuronal expression enhances neurite outgrowth (Tanaka et al., JBC 2007), modulates proliferation cerebellar granule cell precursors PLoS One 2009), associated with survival Neurobiol Dis 2014)....
During the course of neuronal development, an axon is specified by PI3 kinase- and PKA-dependent signaling pathways. However, up-stream factors that modulate activity these kinases remain to be fully elucidated. Recently, we clarified subcellular dynamics Gαs activating G protein-coupled receptor 3 (GPR3) are associated with local activation PKA in cerebellar granular neurons. In current study, focused on possible involvement GPR3 specification. The numbers neurons Tau-1-positive neurites...