A5089580931- Functional Brain Connectivity Studies
- Pain Management and Placebo Effect
- Pain Mechanisms and Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Musculoskeletal pain and rehabilitation
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Heart Rate Variability and Autonomic Control
- Psychosomatic Disorders and Their Treatments
- Chemical Reaction Mechanisms
- COVID-19 epidemiological studies
- Treatment of Major Depression
- Vaccine Coverage and Hesitancy
- Tryptophan and brain disorders
- Psychotherapy Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Neural dynamics and brain function
- SARS-CoV-2 and COVID-19 Research
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Asymmetric Synthesis and Catalysis
- Analytical Chemistry and Sensors
- Traumatic Brain Injury Research
- Stress Responses and Cortisol
- NMR spectroscopy and applications
Hiroshima University
2015-2024
Higashihiroshima Medical Center
2022-2024
Kawamura Hospital
2024
Hiroshima University Hospital
2024
Nihon University
1998-2024
Scripps Health
2015
The University of Tokyo
2013
Nagoya Institute of Technology
1989-2002
Cognitive behavioral therapy (CBT), an effective treatment for depression, targets self-referential processing of emotional stimuli. We examined the effects CBT on brain functioning during in depressive patients using functional magnetic resonance imaging (fMRI). Depressive (n = 23) and healthy participants 15) underwent fMRI scans a task trait words. The had before after completing total 12 weekly sessions group whereas weeks apart with no intervention. Before undergoing CBT, showed...
Abstract Background Cognitive–behavioral therapy (CBT) is thought to be useful for chronic pain, with the pathology of latter being closely associated cognitive–emotional components. However, there are few resting-state functional magnetic resonance imaging (R-fMRI) studies. We used independent component analysis method examine neural changes after CBT and assess whether brain regions predict treatment response. Methods performed R-fMRI on a group 29 pain (somatoform disorder) patients 30...
Abstract Since optimal treatment at an early stage leads to remission of symptoms and recovery function, putative biomarkers leading diagnosis prediction therapeutic responses are desired. The current study aimed use a metabolomic approach extract metabolites involved in both the major depressive disorder (MDD) response for escitalopram. We compared plasma MDD patients (n = 88) with those healthy participants found significant differences concentrations 20 metabolites. measured Hamilton...
Background Chronic constipation (CC) is one of the most frequently reported gastrointestinal disorders in general population and a prominent problem among university students. The study aimed to evaluate prevalence associated factors CC Japanese Methods This cross-sectional was conducted students at Hiroshima University, Japan. Students answered web questionnaire when making reservation for health checkup (April 1 May 31, 2023). consisted four sections, including baseline characteristics,...
Background Real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) have recently attracted attention as a novel, individualized treatment method for major depressive disorder (MDD). In this study, the antidepressant effect of training left dorsolateral prefrontal cortex (DLPFC) activity was examined. Methods Six patients with MDD completed 5 days sessions. each session, observed BOLD signal within their DLPFC line graph, and attempted to up-regulate using graphical cue....
Anticipation of pain engenders anxiety and fear, potentially shaping perception governing bodily responses such as peripheral vasomotion through the sympathetic nervous system (SNS). Sympathetic innervation vascular tone during has been quantified using a arterial stiffness index; however, its role anticipation remains unclear. This paper reports on neuroimaging-based study designed to investigate responsivity attribution index at different levels anticipatory perception. The was measured in...
Abstract Background Although patients with Treatment Resistant Depression (TRD) often have impaired social functioning, few studies investigated the effectiveness of psychosocial treatment for these patients. We examined whether adding group cognitive behavioral therapy (group-CBT) to medication would improve both depressive symptoms and functioning patient mild TRD, any improvements be maintained over one year. Methods Forty-three TRD were treated 12 weekly sessions group-CBT. Patients...
The current study used data from a clinical trial to identify variables that are associated with and/or mediate the beneficial effects of 4 psychological chronic pain treatments: one teaching patients self-hypnosis reduce intensity (HYP), change thoughts about (hypnotic cognitive therapy [HYP-CT]), restructuring skills (cognitive [CT]), and providing education (ED; included as an active control condition). Of 17 possible mechanism examined, alpha not corrected for multiple comparisons,...
Social anxiety is characterized by an excessive fear of being embarrassed in social interactions or performance situations. Emotional support can help to decrease diminish distress. Such may play important role at different points interaction. However, it unclear how the beneficial effects are represented brains socially anxious individuals. To explore this, we used same paradigm previously examine emotional on pain caused exclusion. Undergraduates (n = 46) showing a wide range scores...
Abstract Objectives In recent years, a growing number of diffusion tensor imaging (DTI) studies have compared white matter integrity between patients with major depressive disorder (MDD) and bipolar (BD). However, few examined the pathophysiological significance different degrees abnormalities two disorders. The present study comprehensively assessed among healthy controls (HC) euthymic MDD BD using whole‐brain tractography associations cognitive functioning. Methods We performed...
With the spread of Coronavirus disease 2019 (COVID-19), missing learning opportunities due to COVID-19 has been raised as a major concern for university education. We aimed examine effectiveness booster dose vaccines among Japanese students during Omicron variant. enrolled 249 who became close contact and 294 COVID-19-infected though Hiroshima University registration system. Infection rates people in with sick individuals symptoms infected were examined. Close contacts had received showed...
✓ The authors report the case of a peripheral primitive neuroectodermal tumor (PNET) arising in tentorium 5-year-old boy who presented with frequent vomiting and mild palsy left abducent nerve. Following complete surgical excision via transpetrosal approach, patient has thus far been disease free for 7 years. tissue was composed small cells uniform round nuclei minimal identifiable cytoplasm. Homer—Wright rosettes were frequently observed. Immunohistochemical studies demonstrated positive...
Pain is a multidimensional phenomenon. Patients with somatoform pain disorder suffer from long-lasting pain, the pathology being closely associated cognitive–emotional components. Differences between these patients and controls in cerebral responses to stimuli have been reported. However, our knowledge, no studies of evaluated altered pain-related brain activation as modulated by emotional dysregulation. We examined distinct neural mechanism that engaged response two different intensities...
Aim Cognitive impairment may account for functional and occupational disability in patients with bipolar disorder even during periods of euthymia. While imaging suggests structural, neurochemical, abnormalities patients, the pathophysiology these deficits has not been elucidated. It was hypothesized that euthymic would have different cortical activation a verbal fluency task compared to healthy controls, psychosocial functioning be associated prefrontal group. Methods Ten 10 control...
Somatoform pain disorder is associated with psychosocial dysfunction, and psychotherapies, such as cognitive behavioral therapy (CBT), are thought to provide useful interventions address dysfunction well the itself. However, little known about whether CBT for somatoform effective, including long-term course of illness, in non-Western populations. We therefore tailored a program based on an existing protocol examined its effectiveness Japan.Thirty-four Japanese participants (22 women; mean...
Abstract In clinical practice, subjective pain evaluations, e.g., the visual analogue scale and numeric rating scale, are generally employed, but these limited in terms of their ability to detect inaccurate reports, unsuitable for use anesthetized patients or those with dementia. We focused on peripheral sympathetic nerve activity that responds pain, propose a method evaluating sensation, including intensity, sharpness, dullness, using arterial stiffness index. experiment, electrocardiogram,...
Aim Cognitive behavioral therapy (CBT) is known to be effective for patients with persistent somatoform pain disorder (PSPD). Improvement of negative emotions in interpersonal stressful situations has been reported reduce PSPD‐related clinical pain. However, these associations CBT remain unclear. Therefore, we examined the relation between changes and symptoms after by using a multiple regression analysis that included catastrophizing. Methods We analyzed emotional intensity scores 38 PSPD...
Abstract Brain activity associated with pain perception has been revealed by numerous PET and fMRI studies over the past few decades. These findings helped to establish concept of matrix, which is distributed brain networks that demonstrate pain-specific cortical activities. We previously found peripheral arterial stiffness $${\beta }_{\text{art}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mi>β</mml:mi> <mml:mtext>art</mml:mtext> </mml:msub> </mml:math>...