A5051372608- Neuroscience of respiration and sleep
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Sulfur Compounds in Biology
- Adenosine and Purinergic Signaling
- Advanced Chemical Sensor Technologies
- Neonatal and fetal brain pathology
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects and Toxicity Studies
- Heart Rate Variability and Autonomic Control
- Cardiomyopathy and Myosin Studies
- Ion channel regulation and function
- Alcohol Consumption and Health Effects
- Antibiotics Pharmacokinetics and Efficacy
- Tryptophan and brain disorders
- Intensive Care Unit Cognitive Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Vagus Nerve Stimulation Research
- Regulation of Appetite and Obesity
Johnson University
2021-2024
Rutgers, The State University of New Jersey
2020-2024
University of Iowa
2017-2024
Arousal from sleep in response to CO 2 is a critical protective phenomenon. Dysregulation of -induced arousal contributes morbidity and mortality prevalent diseases, such as obstructive apnea sudden infant death syndrome. Despite the nature this reflex, precise mechanism for unknown. Because major regulator breathing, prevailing theories suggest that activation respiratory chemo- mechano-sensors required arousal. However, populations neurons are not involved regulation breathing also...
Summary Objective Sudden unexpected death in epilepsy ( SUDEP ) is the leading cause of patients with refractory epilepsy. Although mechanisms for are incompletely understood, seizure‐induced respiratory arrest (S‐ IRA has been strongly and consistently implicated. A body evidence indicates that serotonin (5‐ HT ), a modulator breathing, plays critical role . Because 5‐ norepinephrine NE systems interact many biologic processes known to modulate breathing seizures, we hypothesized may play...
Hydrogen sulfide (H2S) is a toxin affecting the cardiovascular, respiratory, and central nervous systems. Acute H2S exposure associated with high rate of mortality morbidity. The precise pathophysiology H2S-induced death controversial topic; however, inhibition respiratory center in brainstem commonly cited as cause death. There knowledge gap on toxicity toxic mechanisms acute poisoning brainstem, brain region responsible for regulating many reflective vital functions. Serotonin (5-HT),...
Abstract Acute exposure to high concentrations of hydrogen sulfide (H2S) leads sudden death and, if survived, lingering neurological disorders. Clinical signs include seizures, loss consciousness, and dyspnea. The proximate mechanisms underlying H2S-induced acute toxicity have not been clearly elucidated. We investigated electrocerebral, cardiac, respiratory activity during H2S using electroencephalogram (EEG), electrocardiogram, plethysmography. suppressed electrocerebral disrupted...
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of refractory patients. Although specific mechanisms underlying SUDEP are not well understood, evidence suggests most occurs due to seizure-induced respiratory arrest. also tends happen at night. this may be circumstances which humans find themselves night, such as being alone without supervision or sleeping prone, independent influences sleep state, there a number reasons why night (i.e., circadian influences) could an risk...
Abstract Objective Sudden unexpected death in epilepsy (SUDEP) results more years of potential life lost than any neurological condition with the exception stroke. It is generally agreed that SUDEP happens due to some form respiratory, cardiac, and electrocerebral dysfunction following a seizure; however, mechanistic cause these perturbations unclear. One possible explanation lies adenosinergic signaling. Extracellular levels inhibitory neuromodulator adenosine rapidly rise during seizures,...
It is widely agreed that breathing subject to circadian regulation. Circadian differences in respiratory physiology significantly impact a number of diseases including sleep apnea, asthma, and seizure-induced death. The effect time day on has been previously characterized; however, an endogenous free-running rhythm mammals not described. Furthermore, it assumed rhythms are dependent the hypothalamic suprachiasmatic nucleus (SCN), home mammalian central oscillator, but this shown...
Key points Sudden unexpected death in epilepsy (SUDEP) is the leading cause of premature patients with refractory epilepsy. SUDEP typically occurs during night, although reason for this unclear. We found that, normally entrained mice, time‐of‐day alters vulnerability to seizure‐induced death. free‐running circadian phase These findings suggest that rhythmicity may be responsible increased night‐time prevalence Abstract epilepsy‐related night following a seizure. Many aspects mammalian...
Most of the animal studies using inflammation-induced cognitive change have relied on behavioral testing without objective and biologically solid methods to quantify severity disturbances. We developed a bispectral EEG (BSEEG) method novel algorithm in clinical study. This effectively differentiates between patients with delirium, predict long-term mortality. In present study, we aimed apply our method, which can detect mouse model delirium systemic inflammation induced by...
For an antiseizure medication (ASM) to be effective in status epilepticus (SE), the drug should administered intravenously (i.v.) provide quick access brain. However, poor aqueous solubility is a major problem development of parenteral solutions. Given its multiple mechanisms action, topiramate (TPM) promising candidate for treatment established or refractory SE, as supported by clinical studies using nasogastric tube TPM administration. not clinically available solution i.v. administration,...
Abstract Sudden unexpected death in epilepsy is the leading cause of related death. Currently, there are no reliable methods for preventing sudden epilepsy. The precise pathophysiology unclear; however, convergent lines evidence suggest that seizure-induced respiratory arrest plays a central role. It generally agreed could be averted if patient rapidly ventilated following seizure. diaphragm muscle chest which contracts to draw air into lungs. Diaphragmatic pacing surgical intervention...
Abstract Objective Respiratory arrest plays an important role in sudden unexpected death epilepsy (SUDEP). Adenosine is of interest SUDEP pathophysiology due to its influence on seizures and breathing. The objective this investigation was examine the adenosine seizure severity, seizure‐induced respiratory disruption, using mouse models. Understanding adenosinergic contributions cessation may provide insights into how can be prevented while avoiding increased severity. Methods Our approach...
Alcohol-related poisoning is the foremost cause of death resulting from excessive acute alcohol consumption. Respiratory failure crucial to pathophysiology fatal poisoning. Alcohol increases accumulation extracellular adenosine. Adenosine suppresses breathing. The goal this investigation was test hypothesis that adenosine signaling contributes alcohol-induced respiratory suppression. In first experiment, breathing mice monitored following an injection non-selective receptor antagonist...
Abstract Sleep and metabolism are inextricably linked mutually affect each other. Leptin is a pivotal regulator of metabolic homeostasis, but its effect on sleep-wake regulation remains elusive. Here we demonstrate that leptin acts small subset lateral hypothalamic area (LHA) GABAergic neurons to behavior. We found the selective loss receptors (LepRs) in LHA causes sleep fragmentation without altering total time, while severe obese LepR-null mice can be rescued by restoration LepR signaling....
Abstract Acute exposure to high concentrations of hydrogen sulfide (H 2 S) leads sudden death and, if survived, lingering neurological disorders. Clinical signs include seizures, loss consciousness, and dyspnea. The proximate mechanisms underlying H S-induced acute toxicity have not been clearly elucidated. We investigated electrocerebral, cardiac respiratory activity during S using EEG, EKG plethysmography. suppressed electrocerebral disrupted breathing. Cardiac was comparatively less...
Familial hypertrophic cardiomyopathy (HCM) is a devastating disease caused by mutations in cardiac sarcomeric proteins that result myocyte disarray, fibrosis and hypertrophy. A hallmark of HCM diastolic dysfunction. Systolic function generally preserved or even enhanced; however, some patients develop systolic dysfunction over time. In this study we tested the hypothesis left ventricular (LV) increases with age transgenic mice cardiac‐specific expression mutated alpha tropomyosin...