A5037793760- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Testicular diseases and treatments
- Sexual Differentiation and Disorders
- Sperm and Testicular Function
- Urologic and reproductive health conditions
- Urinary and Genital Oncology Studies
- Ureteral procedures and complications
- Retinal Development and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Kidney Stones and Urolithiasis Treatments
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Urinary Bladder and Prostate Research
- Reproductive Biology and Fertility
- Genital Health and Disease
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Pelvic floor disorders treatments
- Hernia repair and management
- Retinoids in leukemia and cellular processes
- Urinary Tract Infections Management
- Animal Genetics and Reproduction
- Intraocular Surgery and Lenses
- Congenital Anomalies and Fetal Surgery
Nagoya City University
2015-2024
Japanese Urological Association
2024
Mizuho (Japan)
2006-2021
GTx (United States)
2021
Japanese Society of Medical Oncology
2020
Saiseikai Wakakusa Hospital
2016
Kyoto Prefectural University of Medicine
2012-2014
Fukushima Medical University
2014
Institute of Contemporary Art
2014
Institute of Nephro Urology
2014
Background and Purpose: Percutaneous nephrolithotomy (PCNL) is considered the standard procedure for removal of large renal calculi. The development "minimally invasive PCNL" (mini-PCNL) has reduced complications surgery; it also appears to be associated with less morbidity than conventional PCNL (con-PCNL). This study aimed at evaluating efficacy endoscopic intrarenal surgery, using prone-split leg position, flexible ureteroscopy mini-PCNL (mini- combined surgery [ECIRS]) by retrospectively...
Randall plaques (RPs) can contribute to the formation of idiopathic calcium oxalate (CaOx) kidney stones; however, genes related RP have not been identified. We previously reported potential therapeutic role osteopontin (OPN) and macrophages in CaOx stone formation, discovered using genome-recombined mice genome-wide analyses. Here, characterize genetic pathogenesis RPs, we used microarrays immunohistology compare gene expression among renal papillary non-RP tissues 23 formers (SFs) (age-...
Abstract In our previous report, M2-macrophage (Mφs) deficient mice showed increased renal calcium oxalate (CaOx) crystal formation; however, the role of Mφs-related-cytokines and chemokines that affect kidney stone formation remains unknown. Here, we investigated M1/M2s in development by using vitro vivo approaches. The phagocytic rate bone marrow-derived M2Mφs was higher than Mφs M1Mφs on co-culture with tubular cells (RTCs). However, amount attachment RTCs reduced M2Mφs. six hyperoxaluric...
We recently reported evidence suggesting that migrating macrophages (Mϕs) eliminate renal crystals in hyperoxaluric mice. Mϕs can be inflammatory (M1) or anti-inflammatory (M2), and colony-stimulating factor-1 (CSF-1) mediates polarization to the M2Mϕ phenotype. M2Mϕs promote tissue repair regeneration, but it is not clear whether these cells are involved suppressing crystal formation. investigated role of formation during hyperoxaluria using CSF-1–deficient mice, which lack M2Mϕs. Compared...
Abstract Urinary tract infection is a bacterial that commonly occurs in children. Vesicoureteral reflux major underlying precursor condition of urinary infection, and an important disorder the field pediatric urology. sometimes diagnosed postnatally infants with fetal hydronephrosis antenatally. Opinions vary regarding diagnosis treatment vesicoureteral reflux, diagnostic procedures remain debatable. In terms medical interventions, options include either follow‐up observation hope possible...
To clarify metabolic syndrome induced stone formation mechanisms we investigated the and immunohistochemical characteristics associated with renal crystal deposition using a model of mice administered high fat diet ethylene glycol.Ob/Ob Leptin gene deficiencies related were compared wild heterozygous lean mice. Four study groups fed standard food water (control group), normal (high 1% glycol (ethylene group) or plus group). Blood, urine kidney samples taken after 14 days.Ob/Ob in group...
No AccessJournal of UrologyInvestigative Urology1 Apr 2014Expression Profiling microRNA in Cryptorchid Testes: miR-135a Contributes to the Maintenance Spermatogonial Stem Cells by Regulating FoxO1 Yoshinobu Moritoki, Yutaro Hayashi, Kentaro Mizuno, Hideyuki Kamisawa, Hidenori Nishio, Satoshi Kurokawa, Shinya Ugawa, Yoshiyuki Kojima, and Kenjiro Kohri MoritokiYoshinobu Moritoki Department Nephro-Urology, Graduate School Medical Sciences, Nagoya City University, Nagoya, Japan , HayashiYutaro...
Aim Although treatment guidelines for pharmacological therapy schizophrenia and major depressive disorder have been issued by the Japanese Societies of Neuropsychopharmacology Mood Disorders, these not well applied psychiatrists throughout nation. To address this issue, we developed ‘Effectiveness Guidelines Dissemination Education in Psychiatric Treatment (EGUIDE)’ integrated education programs to disseminate clinical guidelines. Additionally, conducted a systematic efficacy evaluation...
To report our initial experience with robot-assisted laparoscopic extravesical ureteral reimplantation using the advancement technique.A total of 15 ureters from nine patients (age range 2-25 years) underwent for management vesicoureteral reflux. The reflux was classified as grade I in one ureter, II two ureters, III seven IV three and V ureters. One five female had a bilateral duplex system, observed all four da Vinci surgical system utilized. Ureteral carried out cases. We also compared...
In mammals, gonadal sex is normally determined by the presence or absence of Y chromosome gene SRY. After expression SRY in sexually indifferent gonad, a number genes encoding transcription factors and growth implicated testis differentiation start to show male-specific expression. However, XX males, these must be up-regulated SRY, but aetiology SRY-negative maleness remains unclear.We examined representative gonad marker male testes.RT-PCR immunohistochemical studies revealed that SOX9,...
To report the method and results of a modified one-stage Koyanagi repair (urethroplasty with parameatal-based fully extended circumferential foreskin flap) to preserve vascularity peripheral portion neourethra, in severe hypospadias.Using skin-incision line as original repair, incision is made approximately 5 mm proximal corona urethral plate incised for chordee. A U-shaped skin then surrounding meatus, dorsal prepuce 8 parallel first incision. The tissue between dartos dissected on side fix...
No AccessJournal of UrologyPediatric Urology1 Aug 2012Ureteral Advancement in Patients Undergoing Laparoscopic Extravesical Ureteral Reimplantation for Treatment Vesicoureteral Reflux Yoshiyuki Kojima, Kentaro Mizuno, Yukihiro Umemoto, Takahiro Yasui, Yutaro Hayashi, and Kenjiro Kohri KojimaYoshiyuki Kojima More articles by this author , MizunoKentaro Mizuno UmemotoYukihiro Umemoto YasuiTakahiro Yasui HayashiYutaro Hayashi KohriKenjiro View All Author...
Melamine was recently identified as a risk factor for renal calculi following the milk powder contamination in China. However, long-term natural history of melamine exposure and its effects remain unknown. We evaluated function other adverse health using rat model administered cyanuric aid, considering age sex. Twelve male F334/N rats each ages 6, 10, 26 weeks (N = 36) were equally assigned to Group M + C or controls. 12 mg · kg-1 day-1 acid 28 days. Serum urine samples kidney sections on...
Chromosome 1p32-p31 deletion syndrome involving the Nuclear factor I/A (NFIA) gene is characterized by corpus callosum hypoplasia or defects and urinary tract defects. Herein we report on a case resembling carrying de novo truncating mutation (c.1094delC; p.Pro365Hisfs*32) in NFIA gene, confirming that haploinsufficiency of major determinant this syndrome.
We investigated the renoprotective ability of healthy people against kidney stone formation. To clarify intratubular crystal kinetics and processing in human kidneys, we performed a quantitative morphological observation nephrectomized renal parenchyma tissues. Clinical data pathological samples from 60 patients who underwent radical nephrectomy for cancer were collected June 2004 to 2010. The retrospectively classified as formers (SFs; n = 30, stones detected by preoperative computed...
Objectives: To investigate influence for the testicular development and to assess usefulness as an animal model, cryptorchid rats were induced by exposure flutamide during fetal period their testes examined histologically. Methods: Flutamide was injected into abdomen of pregnant 7 days from 14th 20th day gestation. The male offspring in which cryptorchidism observed at 28 after birth defined model rats. They divided four groups dosage (2.5 mg, 5 7.5 15 mg per day), weight, spermatogenesis...
To determine the effect of prostate weight on preoperative and postoperative outcomes robotic-assisted laparoscopic radical prostatectomy with a posterior approach to seminal vesicle. This retrospective study examined prospectively collected data 219 prostatectomies performed from May 2011 February 2013. Patients were divided into four groups based pathologic weight: <30 g, 30–49 50–79 ≥80 g. Continence sexual function assessed using validated questionnaires. Of patients, 19, 143, 51, 6 had...