A5023294688- Renal Diseases and Glomerulopathies
- Pediatric Urology and Nephrology Studies
- Urinary Tract Infections Management
- Urological Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Gut microbiota and health
- Urinary Bladder and Prostate Research
- Autoimmune Bullous Skin Diseases
- Kawasaki Disease and Coronary Complications
- Kidney Stones and Urolithiasis Treatments
- Adolescent and Pediatric Healthcare
- Pelvic floor disorders treatments
- Renal and related cancers
- Gastrointestinal motility and disorders
- Dialysis and Renal Disease Management
- Ion Transport and Channel Regulation
- Acute Kidney Injury Research
- Vasculitis and related conditions
- Abdominal vascular conditions and treatments
- Viral gastroenteritis research and epidemiology
- Pharmacological Effects and Toxicity Studies
- Probiotics and Fermented Foods
- Metabolism and Genetic Disorders
- Streptococcal Infections and Treatments
- Coronary Artery Anomalies
Kansai Medical University
2015-2025
Japanese Society of Medical Oncology
2020
Gifu University
2006
Osaka City University
2004
The mode of delivery (vaginal or cesarean section) and feeding type (breastfeeding formula feeding) neonates are considered the most influential factors in development gut microbiota.This study investigated effect prebiotic-rich breast milk on overcoming microbiota dysbiosis.Stool samples from 36 healthy Japanese were obtained at 4 days 1 month age, divided into groups based type. composition bacterial diversity assessed using 16S rRNA sequencing.At old, vaginally delivered had a...
Abstract Urinary tract infection is a bacterial that commonly occurs in children. Vesicoureteral reflux major underlying precursor condition of urinary infection, and an important disorder the field pediatric urology. sometimes diagnosed postnatally infants with fetal hydronephrosis antenatally. Opinions vary regarding diagnosis treatment vesicoureteral reflux, diagnostic procedures remain debatable. In terms medical interventions, options include either follow‐up observation hope possible...
Pseudohypoaldosteronism type II (PHA II), also referred to as Gordon syndrome, is a rare renal tubular disease that inherited in an autosomal manner. Though mutations WNK1 and WNK4 partially account for this disorder, 2012, 2 research groups showed KLHL3 CUL3 were the causative genes PHA II. Here, we firstly report on Japanese child of caused by mutation CUL 3. The patient was 3-year-old girl having healthy unrelated parents. She initially observed have hyperkalemia, hyperchloremia,...
Abstract The pathogenesis of idiopathic nephrotic syndrome ( INS ) remains unknown. Recently, it was postulated that suppression regulatory T cells (Treg) leads to massive proteinuria in , although there is some controversy. Considering the important role cytotoxic T‐lymphocyte‐associated protein 4 CTLA ‐4) Treg‐mediated immune suppression, aim this study therefore clarify involvement Treg and ‐4 . Fifteen patients with were enrolled. Their blood sampled twice, once at onset remission...
<b><i>Background:</i></b> While the etiology of idiopathic nephrotic syndrome (idiopathic [INS]; characterized by repeated relapses and comorbid allergic conditions) remains unknown, recent evidence suggests that dysfunction in regulatory T cells (Tregs) plays an important role development INS as well diseases. We hypothesized dysbiosis involving decreased butyric acid-producing gut microbiota leads to defective induction differentiation peripherally induced Tregs,...
We previously reported that a decrease in butyrate-producing bacteria the gut is potential cause of regulatory T cell (Treg) abnormalities children with idiopathic nephrotic syndrome (INS). Therefore, we hypothesized administration might reduce INS relapse and need for immunosuppressants these patients. Twenty patients remission from (median age 5.3 years, 15 boys) were enrolled study assigned to receive either daily oral treatment preparation 3 g Clostridium butyricum or no probiotic...
Butyric acid produced in the intestine by butyric acid-producing bacteria (BAPB) is known to suppress excessive inflammatory response and may prevent chronic disease development. We evaluated whether fiber-rich barley intake increases BAPB gut concomitantly feces. Eighteen healthy adults received granola containing functional (BARLEYmax®) once daily for four weeks. Fecal DNA before intake, after one month was analyzed using 16S rRNA gene sequencing assess microbial diversity, composition at...
8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG), also known as 8-hydroxy-2′-deoxyguanosine (8-OHdG), is an oxidatively damaged nucleobases of DNA and excreted into urine. Therefore, its urinary level used a sensitive marker for oxidative stress (OS). Although it can be measured by enzyme-linked immunosorbent assay (ELISA), application to clinical pediatrics remains limited. Recently, novel automatic analyzer (model no. ICR-001: Techno Medica Co., Ltd., Japan) has been developed point-of-care...
Recurrent febrile urinary tract infections during infancy cause renal scarring, which is characterized by progressive focal interstitial fibrosis and may lead to failure. Renal scarring can be diagnosed through scintigraphy, although it seems impractical perform scintigraphy for all infants with infections. Therefore, important search a biomarker identify the presence of scarring. We hypothesized that biomarkers nephropathy increase in following infections.A total 49 who underwent were...
We evaluated the effect of long-term low dose antibiotic prophylaxis on children's gut microbiota.We conducted 16S ribosomal RNA gene sequencing using stool samples from 35 patients younger than 3 years old (median age 5.2 months; male-to-female ratio 17:18) who underwent treatment during acute phase febrile urinary tract infection. Samples were collected at 5 time points, ie before, and 1 to 2, 4, 6 months after infection onset treatment. Continuous trimethoprim-sulfamethoxazole was...
<b><i>Background:</i></b> Though rituximab (RTX) is effective for childhood steroid-dependent nephrotic syndrome (SDNS), an established regimen does not exist. The relapses tend to occur when the peripheral blood B-cell count re-arises at 3 months upon single RTX infusion. This study was conducted clarify whether long-term remission of SDNS can be obtained by repeated administrations. <b><i>Methods:</i></b> administered 4 times 3-month...
Febrile urinary tract infection (fUTI) is common in infants, but specific risk factors for developing it remain unclear. As most fUTIs are caused by ascending infections of intestinal bacteria, dysbiosis—an imbalance gut microbial communities—may increase fUTI risk. This study was conducted to test the hypothesis that abnormal development microbiota during infancy increases fUTI. Stool samples were collected from 28 infants aged 3–11 months with first-onset (fUTI group) and 51 healthy same...
Minimal-change nephrotic syndrome (MCNS) is a kidney disease defined by selective proteinuria and hypoalbuminemia occurring in the absence of cellular glomerular infiltrates or immunoglobulin deposits. Recent observations suggest that nuclear factor κB (NF-κB) podocyte strongly associated with development MCNS. Dehydroxymethylepoxyquinomicin (DHMEQ) novel NF-κB inhibitor potently inhibits DNA-binding activity NF-κB, resulting several therapeutic effects various pathological conditions. We...
Sleep disorders are strongly associated with childhood nocturnal enuresis (NE). In this study, we examined whether sleep present in children NE, and NE is caused by sleeping disorders, or simply comorbid.We 14 monosymptomatic 15 age-matched controls. were assessed for ≥5 days using contactless biomotion sensors to detect breathing body movements during at-home sleep. To assess quality, compared median efficiency the number of shallow episodes between groups. We also investigated change...