A5025356231- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Heavy metals in environment
- Effects and risks of endocrine disrupting chemicals
- Arsenic contamination and mitigation
- Isotope Analysis in Ecology
- Analytical chemistry methods development
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Fluoride Effects and Removal
- Thyroid Disorders and Treatments
- Trace Elements in Health
- Radioactivity and Radon Measurements
- Birth, Development, and Health
- Pesticide Exposure and Toxicity
- Archaeology and ancient environmental studies
- Forensic Anthropology and Bioarchaeology Studies
- Environmental Justice and Health Disparities
- Extraction and Separation Processes
- Marine animal studies overview
- Pacific and Southeast Asian Studies
- Selenium in Biological Systems
- Recycling and Waste Management Techniques
- Radioactive contamination and transfer
National Institute for Environmental Studies
1997-2025
Toyo University
2016-2025
Turība University
2025
Kitasato University
2008-2024
The University of Tokyo
2010-2022
Sir Charles Gairdner Hospital
2020
Erasmus MC
2020
Biogipuzkoa Health Research Institute
2020
Nagoya University
2015
Kagoshima University
2015
Summary Phthalate esters, commonly used as plasticizers, show anti‐androgenic activity and cause male reproductive malformation in experimental animals. However, the effects of prenatal exposure to phthalate esters humans have not been extensively studied. The purpose this study was examine relationship between anogenital distance (AGD) a endpoint human newborns. Spot urine samples were collected from 111 Japanese pregnant women after obtaining their informed consent. Seven urinary ester...
We evaluated the effect of environmental, low-level exposure to heavy metals during pregnancy, as estimated by urine analysis, on birth size newborns. Spot samples were collected from unexposed 78 pregnant women in Tokyo 2007 and 2008. The urinary concentrations beryllium (Be), copper (Cu), arsenic (As), zinc (Zn), selenium (Se), molybdenum (Mo), cadmium (Cd), tin (Sn), antimony (Sb), lead (Pb) measured ICP-MS. birthweight (BW), length (BL) head circumference (HC) newborns delivered subjects...
The carcinogenic activity of bisphenol A (BPA) is responsible for stimulating growth in estrogen-dependent breast cancer tissues, cell lines and rodent studies. However, it not fully understood how this compound promotes mammary carcinogenesis. In our study, we examined the effect BPA on cellular proliferation senescence human epithelial cells (HMEC). Exposure to 1 week at early stage passage 8 increased sphere size HMEC later up 16, suggesting that has capability modulate cells....
The aim of this study was to assess the performance a method analyzing organic esters plasticizer in indoor air by sampling charcoal tube and extracting toluene using gas chromatography−mass spectrometer (GC−MS) flame photometric detector (FPD). An internal standardization used for GC−MS measurement phthalate esters, whereas an external calibration employed determine levels phosphate FPD. instrumental detection limit, lower limit determination, blank limits were also determined. Mean...
Our objectives were (1) to evaluate whether single spot urine is suitable media for longer-term phthalate esters exposure assessment, and (2) estimate intake level of Japanese pregnant women using urinary metabolites as an indicator prenatal in their offspring.We analyzed nine (MMP, MEP, MnBP, MBzP, MEHP, MEOHP, MEHHP, MINP, MnOP) seven samples from 50 by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Using four collected each 12 subjects within 5-12 weeks, we...
ある小規模下水処理場をめぐる殺虫剤フィプロニルの挙動について調査した。処理場流入水及び処理後の放流水を月1回1年間採取し,併せて処理水放流先の小河川の河川水を,処理場の上流側・下流側から採取した。これらの水試料中のフィプロニルおよび分解物のフィプロニルスルホン,フィプロニルスルフィド,フィプロニルデスルフィニルの4種(あわせてフィプロニル類という)の濃度をLC-MS/MSで定量した。下水処理場流入水および放流水全試料でフィプロニルが検出された(中央値 1.8 ng/Lおよび 2.1 ng/L)が分解物の検出頻度は低かった。流入水と放流水中フィプロニル類の濃度間に統計学的な差はなく,下水処理によるフィプロニル類の除去は効果的ではないことが示唆された。一方,下水処理水の放流先の小河川中でも,フィプロニルの検出頻度は高かったが,下水試料よりも低濃度であり(上流・下流側中央値 0.22 0.41...
ABSTRACT Rationale Carbon and nitrogen stable isotope ratios (δ 13 C δ 15 N) of whole diet have rarely been measured to date though the in human sample extensively used for nutritional researches. In order fully validate dietary analysis, isotopic information is required. Methods N 150 duplicate samples collected Japan during 2016–2017 were measured. Sixty‐five males 85 females (mean age: 45 years) donated which by element analyzer‐isotope ratio mass spectrometry. Results Mean diets −24.3...