A5071666594- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Hormonal and reproductive studies
- Hypothalamic control of reproductive hormones
- Ovarian function and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Biochemical effects in animals
- Biochemical Acid Research Studies
- Endometriosis Research and Treatment
- Birth, Development, and Health
- Menstrual Health and Disorders
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Exercise and Physiological Responses
- Trace Elements in Health
- Effects and risks of endocrine disrupting chemicals
- Tryptophan and brain disorders
- Heavy Metal Exposure and Toxicity
- Alzheimer's disease research and treatments
- Biochemical Analysis and Sensing Techniques
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Apelin-related biomedical research
- Pain Mechanisms and Treatments
Fırat University
2015-2024
Ondokuz Mayıs University
2024
Elazığ Eğitim ve Araştırma Hastanesi
2020
<b><i>Introduction:</i></b> Obesity is known to cause sexual dysfunction including erectile and poor semen quality. Lifestyle modifications such as exercise have increasingly been more recognized lower the likelihood of having or infertility in obese men. In this context, an exercise-mimetic hormone, irisin has a potential improve obesity-related reproductive dysfunctions. We aimed elucidate possible effects on high-fat diet (HFD)-induced male rats....
Physical exercise and body muscle/fat mass are known to affect the endocrine system, puberty onset reproductive health. However, potential effects of irisin, an adipo-myokine exercise-induced hormone, have not yet been fully elucidated on maturation. Therefore, present study aimed determine irisin administration pubertal maturation system in female male rats. Daily i.p. injection (100 ng/kg; from postnatal day 21 for about 10 weeks) delayed ages at vaginal opening (as external index onset)...
The main aim of this study was to investigate the effects irisin on asprosin, leptin, glucose levels and lipid profile in healthy obese male female rats.Irisin subcutaneously administered with osmotic minipumps at dose 100 ng/kg/day for 28 days then, serum were investigated.Irisin infusion increased asprosin rats (p = .02) but not rats. Irisin inhibited obesity-induced high glucose, low-density lipoprotein (LDL), triglyceride (TG) leptin all groups; however, it did lead any change both...
Obesity is becoming more common all across the world, causing a variety of health problems, including reproductive disruption. Although novel, exercise-induced hormone irisin may affect hypothalamus-pituitary-gonadal axis and function control, its impact on obesity-induced damage to female system not fully known. Hence, this study aimed investigate potential effects hormones organs in rats with obesity induced by high-fat diet. Forty were divided into four groups: irisin, obese, obese+irisin...
Antidepressant use in adolescents has become more common recent years. We have found several studies stating that prenatal antidepressant exposure can lead to delayed or earlier puberty onset but there was no study on postnatal paroxetine bupropion. The main aim of this investigate the effect bupropion onset, reproductive and feeding results. male rats (n = 8/group) aged 21 days were exposed (3.6 mg/kg) (17 orally by gastric gavage every day from 21-90. Also, control group received only...
Opioid analgesics have been used for a long time in the treatment of acute and chronic pain. However, they many side effects including tolerance development to significant extent. Agomelatine, an atypical antidepressant, has demonstrated be effective experimental studies on effect agomelatine morphine its mechanism action are unknown. The antinociceptive agomelatine, their combination were assessed mice model painful diabetic neuropathy. roles glutamate ionotropic receptor...
Insomnia, which is associated with menopausal depression, a common symptom of menopause. Both symptoms have etiology, and can affect each other significantly. Pharmacological interventions, including hypnotics antidepressants, non-pharmacological therapies are generally administered in clinical practice for insomnia treatment. As another disorder, osteoporosis described as disease low bone mineral density (BMD), affecting nearly 200 million women worldwide. Postmenopausal among middle-aged...
Exposure to chronic stress stimulates the hypothalamic-pituitary-adrenal (HPA) axis and then simultaneously inhibits hypothalamic-pituitary-gonadal (HPG) activity. The inhibition formed by HPA is main mechanism of action on reproductive function. HPG activity known be changed various factors, including exercise. Exercise has been found have a number positive effects sexual behavior, hormones, sperm parameters in studies with animal models for many years. aim this study investigate treadmill...
Prenatal tobacco-smoke exposure negatively affects the reproductive functions of female offspring and oxidative stress plays a major role at this point. Alpha-lipoic acid (ALA), well known as biological antioxidant, has been used nutritional supplement therapeutic agent in treatment certain complications during pregnancy. We aimed to investigate effects maternal and/or ALA administration on puberty onset, sexual behavior, gonadotrophin levels, apoptosis-related genes, apoptotic cell numbers...
Exercise hormone irisin, a thermogenic adipo-myokine, promotes energy expenditure by white adipose tissue browning. Considering that irisin improves the metabolic profile and increases whole-body expenditure, it is thought may be potential new therapeutic target for treatment of growing epidemic obesity. The roles mast cells angiogenesis in pathogenesis obesity are known, importance loss cell function antiangiogenic agents has gained prominence recent years. In addition, efficacy oxytocin...
Levamisole is an anti-helminthic drug developed and introduced in veterinary medicine, it has been used more frequently after the inclusion of its usage human medicine regarding disorders with immunomodulatory properties. In recent years, started to attract attention since beneficial effects on treatment COVID-19 due To investigate levamisole sexual behavior reproductive system male rats, two groups were formed vehicle (