A5016634905- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Lipid metabolism and biosynthesis
- Hepatocellular Carcinoma Treatment and Prognosis
- Endoplasmic Reticulum Stress and Disease
- Wnt/β-catenin signaling in development and cancer
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Liver physiology and pathology
- interferon and immune responses
- Metabolism and Genetic Disorders
- NF-κB Signaling Pathways
- Adipose Tissue and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Gallbladder and Bile Duct Disorders
- Genetic factors in colorectal cancer
- Lipid metabolism and disorders
Johannes Gutenberg University Mainz
2016-2024
University Medical Center of the Johannes Gutenberg University Mainz
2017-2024
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2021-2024
University Hospital Schleswig-Holstein
2024
University of Lübeck
2024
Heidelberg University
2011-2022
University Hospital Heidelberg
2010-2019
Daimler (Germany)
2017
Chirurgische Universitätsklinik Heidelberg
2010-2015
Hôpital Lyon Sud
2006-2014
Integrin α(3) is a transmembrane integrin receptor subunit that mediates signals between the cells and their microenvironment. We identified three patients with homozygous mutations in gene were associated disrupted basement-membrane structures compromised barrier functions kidney, lung, skin. The had multiorgan disorder included congenital nephrotic syndrome, interstitial lung disease, epidermolysis bullosa. renal respiratory features predominated, involvement accounted for lethal course of...
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty disease, encompasses steatosis and metabolic steatohepatitis (MASH), leading to cirrhosis hepatocellular carcinoma. Preclinical MASLD research is mainly performed in rodents; however, the model that best recapitulates human yet be defined. We conducted a wide-ranging retrospective review (metabolic phenotype, histopathology, transcriptome benchmarked against humans) of murine...
Fatty change (steatosis) is the most frequent liver pathology in western countries and caused by a broad range of disorders such as alcohol abuse metabolic syndrome. The surface layer lipid droplets (LDs) contains members protein family that share homologous sequences domains, so-called PAT proteins, named after their constituents, perilipin, adipophilin, TIP47. We characterized LD-associated proteins normal diseased connected with LD accumulation. Adipophilin TIP47 are expressed LDs vitamin...
Abstract Loss of H4 lysine 16 (H4K16) acetylation was shown to be a common feature in human cancer. However, it remained unclear which enzyme is responsible for the loss this modification. Having recently identified histone acetyltransferase MOF (hMOF) required bulk H4K16 acetylation, here we examined involvement hMOF expression and breast cancer medulloblastoma. Analysis recent mRNA profiling study ( n = 100 cases) an array‐CGH screen medulloblastomas 102 cases), revealed downregulation 40%...
Tissue homeostasis and remodeling are processes that involve high turnover of biological macromolecules. Many the waste molecules by-products or degradation intermediates macromolecule enter circulation subsequently cleared by liver sinusoidal endothelial cells (LSEC). Besides mannose receptor, stabilin-1 stabilin-2 major scavenger receptors expressed LSEC. To more clearly elucidate functions -2, we have generated mice lacking stabilin-1, stabilin-2, both -2 (Stab1–/–Stab2–/– mice). Mice...
In Wilson disease (WD), functional loss of ATPase copper-transporting β (ATP7B) impairs biliary copper excretion, leading to excessive accumulation in the liver and fulminant hepatitis. Current US Food Drug Administration- European Medicines Agency-approved pharmacological treatments usually fail restore homeostasis patients with WD who have progressed acute failure, leaving transplantation as only viable treatment option. Here, we investigated therapeutic utility methanobactin (MB), a...
Acute liver failure (ALF) in infancy and childhood is a life-threatening emergency. Few conditions are known to cause recurrent acute (RALF), about 50% of cases, the underlying molecular remains unresolved. Exome sequencing five unrelated individuals with fever-dependent RALF revealed biallelic mutations NBAS. Subsequent Sanger NBAS 15 additional or ALF identified compound heterozygous an six from families. Immunoblot analysis mutant fibroblasts showed reduced protein levels its proposed...
Lipid droplets (LDs) are dynamic storage compartments for energy-rich fats that nearly ubiquitously present in eukaryotic cells, exerting tissue-specific functions metabolically active cell types, and increased conditions following cellular damage or lipid overload. The LD-cytoplasm interface is stabilized by amphiphilic proteins of the PAT/perilipin family (perilipin/perilipin-1, adipophilin/perilipin-2, TIP47/perilipin-3). We evaluated value adipophilin immunohistochemistry diagnosis...
IκB kinase/nuclear factor κB (IKK/NF-κB) signaling exhibits important yet opposing functions in hepatocarcinogenesis. Mice lacking NEMO liver parenchymal cells (LPC) spontaneously develop steatohepatitis and hepatocellular carcinoma (HCC) suggesting that NF-κB prevents disease cancer. Here, we show complete inhibition by combined LPC-specific ablation of RelA, c-Rel, RelB did not phenocopy deficiency, but constitutively active IKK2-mediated activation prevented damage HCC NEMOLPC-KO mice....
Summary Background Advanced fibrosis has been established as the most important predictor of overall mortality in patients with non‐alcoholic fatty liver disease ( NAFLD ). In contrast to cirrhosis, advanced, non‐cirrhotic is difficult identify and data from Germany are lacking. Aim To clinical factors associated fibrosis. Methods Patients were recruited prospectively enrolling European Registry. Clinical characteristics performance non‐invasive surrogate scores compared vibration‐controlled...
Summary Background Lifestyle modifications remain the cornerstone of treatment in non‐alcoholic fatty liver disease (NAFLD). However, they requently fail related to inability patients implement lasting changes. Aims To evaluate effects a short, web‐based, individualised exercise program on non‐invasive markers hepatic steatosis, inflammation and fibrosis. Methods Patients with histologically confirmed NAFLD underwent an 8‐week, that contained bidirectional feedback. Results Forty‐four...
Diagnosis of metastatic breast cancer is associated with a very poor prognosis. New therapeutic targets are urgently needed, but their development hampered by lack understanding the mechanisms leading to tumor metastasis. Exemplifying this fact that approximately 30% all cancers overexpressing receptor tyrosine kinase ErbB-2 characterized high potential and prognosis, signaling events downstream drive cell invasion metastasis remain incompletely understood. Here we show overexpression in...
Noninvasive assessment of disease activity in patients with nonalcoholic fatty liver (NAFLD) and alcoholic (ALD) is still unsettled, but essential for the evaluation progression. We here studied association total (M65) caspase‐cleaved (M30) serum keratin‐18 fragments (n = 204) histological parameters 106) heavy drinkers primarily admitted alcohol withdrawal before after detoxification. An age‐, sex‐, fibrosis‐stage matched NAFLD cohort 30) was used comparison. The prognostic value M30 M65...
Objective Alcohol-related liver disease (ALD) ranges from never-decompensated ALD (ndALD) to the life-threatening decompensated phenotype, known as alcohol-related hepatitis (AH). A multidimensional study of clinical, histological and molecular features these subtypes is lacking. Design Two large cohorts patients were recruited in an international, observational multicentre study: a retrospective cohort with ndALD (n=110) prospective AH (n=225). Clinical, analytical, immunohistochemistry...
The anucleate prismoid fiber cells of the eye lens are densely packed to form a tissue in which plasma membranes and their associated cytoplasmic coat single giant cell-cell adhesive complex, cortex adhaerens. Using biochemical immunoprecipitation methods various species (cow, pig, rat), combination with immunolocalization microscopy, we have identified two different major kinds cortical complex. In one, transmembrane glycoproteins N-cadherin cadherin-11 [which also occur heterotypic...