A5085505245- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Diet and metabolism studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Social and Demographic Issues in Germany
- Colorectal Cancer Surgical Treatments
- Exercise and Physiological Responses
- Health and Medical Studies
- Gastric Cancer Management and Outcomes
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sociology and Education Studies
- Drug-Induced Hepatotoxicity and Protection
- Diabetes and associated disorders
- Colorectal Cancer Treatments and Studies
- Nutrition and Health in Aging
- Clinical practice guidelines implementation
- Sex and Gender in Healthcare
- Ethics in medical practice
University Medical Center of the Johannes Gutenberg University Mainz
2016-2024
Johannes Gutenberg University Mainz
2016-2024
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2017-2024
University Medical Center
2020
IQVIA (United Kingdom)
2020
University Children's Hospital Zurich
2004-2013
Universitätskinderklinik
2011
Bachem (Switzerland)
2005
GEO Partner (Switzerland)
2005
The prevalence of nonalcoholic steatohepatitis (NASH) associated hepatocellular carcinoma (HCC) is increasing. However, strategies for detection early-stage HCC in patients with NASH have limitations. We assessed the ability GALAD score, which determines risk based on patient sex; age; and serum levels α-fetoprotein (AFP), AFP isoform L3 (AFP-L3), des-gamma-carboxy prothrombin (DCP), to detect NASH.We performed a case-control study 125 (20% within Milan Criteria) 231 without (NASH controls)...
Brominated flame retardants (BFRs) are synthetic additives mainly used in electrical and electronic appliances construction materials. The properties of some BFRs typical for persistent organic pollutants, certain BFRs, particular polybrominated diphenyl ether (PBDE) congeners hexabromocyclododecane (HBCD), suspected to cause adverse health effects. Global consumption the most demanded i.e., penta-, octa-, decaBDE, tetrabromobisphenol A (TBBPA), HBCD, has doubled 1990s. Only limited rather...
Summary Background Advanced fibrosis has been established as the most important predictor of overall mortality in patients with non‐alcoholic fatty liver disease ( NAFLD ). In contrast to cirrhosis, advanced, non‐cirrhotic is difficult identify and data from Germany are lacking. Aim To clinical factors associated fibrosis. Methods Patients were recruited prospectively enrolling European Registry. Clinical characteristics performance non‐invasive surrogate scores compared vibration‐controlled...
Nonalcoholic fatty liver disease (NAFLD), depression, and anxiety disorders are frequent diseases, data on mutual influence inconsistent. The aim of this study was to explore the incidence depression in a large primary care cohort Germany impact NAFLD over 10-year time frame. Patients with diagnosed between 2010 2015 were matched without controlling for age, sex, physician, index year, Charlson comorbidity index. outcome anxiety, first prescription antidepressant drugs. We compared 19,871...
Minimal hepatic encephalopathy (HE) and HE grade 1 (HE1) according to the West Haven criteria have recently been grouped as one entity named-covert HE- (CHE). Data regarding impact of CHE on health-related quality life (HRQoL) sleep are controversial.First, determine whether affects HRQoL cirrhotic patients second, minimal (MHE) HE1 affect a comparable extent.A total 145 consecutive were enrolled. was diagnosed clinically criteria. Critical flicker frequency Psychometric Hepatic...
Summary Background Lifestyle modifications remain the cornerstone of treatment in non‐alcoholic fatty liver disease (NAFLD). However, they requently fail related to inability patients implement lasting changes. Aims To evaluate effects a short, web‐based, individualised exercise program on non‐invasive markers hepatic steatosis, inflammation and fibrosis. Methods Patients with histologically confirmed NAFLD underwent an 8‐week, that contained bidirectional feedback. Results Forty‐four...
Abstract Background A recently developed haemostatic peptide gel for endoscopic application has been introduced to improve the management of gastrointestinal bleeding. The aim this pilot study was evaluate feasibility, safety, efficacy and indication profiles PuraStat in a clinical setting. Methods In prospective observational multicentre study, patients with acute non-variceal bleeding (upper lower) were included. Primary secondary evaluated. Haemoglobin, prothrombin time, platelets...
The prevalence of liver disease, and especially advanced fibrosis, in the German population is poorly defined. aim study was to explore enzymes surrogate scores hepatic steatosis fibrosis a population-based cohort Germany. In cross-sectional Gutenberg Health study, data 14,950 participants enrolled between 2007 2012 were captured analyzed. distribution alanine aminotransferase (ALT), aspartate (AST), gamma-glutamyltransferase (GGT), fatty index (FLI), Fibrosis-4 (FIB-4) score, as well...
Summary Background The current management of metabolic dysfunction‐associated steatotic liver disease (MASLD) relies on lifestyle intervention. Prior studies have shown that nutritional wheat amylase trypsin inhibitors (ATI) activate toll‐like receptor 4 intestinal myeloid cells to enhance and extra‐intestinal inflammation, including the promotion murine MASLD, insulin resistance fibrosis. Aims We aimed assess impact ATI (gluten)‐free diet in as well parameters biopsy‐proven MASLD patients....
Systemic inflammation is a driving force for the development of hepatic encephalopathy and recent studies demonstrated that elevated Interleukin-6 (IL-6) serum levels are associated with presence minimal in patients liver cirrhosis.To test hypothesis IL-6 suitable marker to identify cirrhosis at high risk overt encephalopathy.201 were included into this prospective cohort study followed mean time 322 days. Covert was diagnosed according West-Haven criteria (hepatic grade 1) portosystemic...
(1) Background: The etiology of non-alcoholic fatty liver disease (NAFLD) is multifactorial. Dietary composition has been implicated as a factor modulating intestinal barrier and could affect severity. aim this study was to evaluate dietary intake markers permeability in patients with NAFLD. (2) Methods: We enrolled 63 NAFLD compared them age-matched controls. (3) Results: body mass index (BMI) leptin adiponectin ratio—the latter being an indicator abdominal fat accumulation—correlated the...
Abstract Reproducible animal models to recapitulate the pathophysiology of non-alcoholic fatty liver disease (NAFLD) are urgently required improve understanding mechanisms injury and explore novel therapeutic options. Current guidelines recommend life-style interventions as first-line therapy for NAFLD these types intervention considered standard-of-care. The current study establishes a reproducible mouse model in using voluntary wheel running (VWR). Male C57BL/6J mice were fed high-fat,...
Objective: Metabolic risk factors and nonalcoholic fatty liver disease (NAFLD) in people with HIV (PWH) have been increasing. Patients exhibiting the inflammatory subtype steatohepatitis (NASH) are at increased of liver-related complications. Therefore, aim was to investigate prevalence NASH significant fibrosis PWH using noninvasive tests (NITs). Design: In this prospectively enrolling cohort study, 282 were explored for hepatic steatosis, vibration-controlled transient elastography (VCTE)...
OBJECTIVES: Diagnosis of covert hepatic encephalopathy (CHE) is challenging and often neglected in clinical practice. The aim this study was to develop an easy-to-perform score predict CHE patients with cirrhosis. METHODS: For the development or validation cohort proposed score, 142 96 consecutive cirrhosis were prospectively enrolled. Psychometric Hepatic Encephalopathy Score used detect minimal encephalopathy. All examined simplified animal naming test asked complete Chronic Liver Disease...
Cardiovascular disease (CVD) is the leading cause of death in patients with nonalcoholic fatty liver (NAFLD). The current analysis expands knowledge on atherogenic lipid profiles NAFLD by modeling changes low-density lipoprotein cholesterol (LDL-C) and total (TC) a prospectively enrolling real-life study cohort to inform physicians cardiovascular (CV) event risk based these changes. A 304 histologically confirmed were included (mean age, 52 years; equal sex distribution). Of these, 129...
The incidence of cancer is increasing worldwide. role comorbidities in this development debated. aim study was to investigate the significance non-alcoholic fatty liver disease (NAFLD) for various kinds Germany.Between 2000 and 2015, data on 31 587 patients with established NAFLD were collected analysis. A control group (n = 587) assembled comparison matched sex, age, treating physician, Charlson Comorbidity Index (CCI).By 10 years after index date, 15.3% 13.4% had been diagnosed (p <0.001)....
Background: Physical inactivity is a major risk factor for nonalcoholic fatty liver disease (NAFLD). Exercise-based prevention interventions improving cardiorespiratory fitness are recommended complementary treatment NAFLD. Achievement of minimally effective physical activity to improve among patients typically involves high personal and financial expenses in face-to-face settings. We designed an eHealth approach with NAFLD the report first results HELP (Hepatic Inflammation Performance...
INTRODUCTION: Despite the negative impact of covert hepatic encephalopathy on outcome patients with liver cirrhosis, data regarding ability different testing strategies to predict overt (OHE) development and mortality are limited. This study aimed compare Psychometric Hepatic Encephalopathy Score (PHES), critical flicker frequency (CFF), simplified animal naming test (S-ANT1), clinical (CCHE) score OHE mortality. METHODS: A total 224 cirrhosis were tested prospectively followed up clinically...
Abstract Hepatic steatosis (HS) related to nonalcoholic fatty liver disease (NAFLD) is increasing globally. In people living with human immunodeficiency virus (PLWH) risk factors of HS are increased. The impact on outcomes and in particular health‐related quality life (HRQL) PLWH remains unknown. aim this cross‐sectional cohort study (FLASH, Prevalence Advanced Fibrosis Patients Living With HIV) was determine the contribution HRQL identify confounders HRQL. A total 245 were prospectively...
In the primary and secondary prevention of civilization diseases, regular physical activity is recommended in international guidelines to improve disease-related symptoms, delay progression disease, or enhance postoperative outcomes. preoperative context, there has been a paradigm shift favor using preconditioning concepts before surgery. Web-based interventions seem an innovative effective tool for delivering general information, individualized exercise recommendations, peer support.Our...
Abstract Physical activity confers a broad spectrum of health benefits. Beyond the obvious role in metabolically driven diseases, physical acute liver injury is poorly explored. To study injury, novel model voluntary distance running mice was developed and were subjected to induced by N -galactosamine (GalN) lipopolysaccharide (LPS). Analyses included histological stains, immunoblotting, qRT-PCR FACS analysis. Voluntary increased an average 10.3 km/day after learning curve. Running lead...