A5015454954- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Nutrition and Health in Aging
- Frailty in Older Adults
- HIV-related health complications and treatments
- COVID-19 and healthcare impacts
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Dialysis and Renal Disease Management
- SARS-CoV-2 detection and testing
- Biochemical effects in animals
- Diabetes and associated disorders
- Hepatitis Viruses Studies and Epidemiology
- Health Literacy and Information Accessibility
- Organ Transplantation Techniques and Outcomes
- Body Composition Measurement Techniques
- Clinical Nutrition and Gastroenterology
- Hip and Femur Fractures
- Biosensors and Analytical Detection
- Intensive Care Unit Cognitive Disorders
University Medical Center of the Johannes Gutenberg University Mainz
2020-2024
Johannes Gutenberg University Mainz
2020-2024
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2024
Diagnosis of minimal hepatic encephalopathy (MHE) requires psychometric testing, which is time-consuming and often neglected in clinical practice. Elevated Interleukin-6 (IL-6) serum levels have been linked to MHE. The aim this study was investigate the usefulness IL-6 as a biomarker stepwise diagnostic algorithm detect MHE patients with liver cirrhosis. A total 197 prospectively recruited without signs (HE) served development cohort. Another independent cohort consisting 52 for validation...
Summary Background Diabetes mellitus may lead to increased serum ammonia and systemic inflammation thereby promoting hepatic encephalopathy (HE). Aim To investigate the potential association between diabetes mellitus/glycaemic control presence of covert HE as well development overt in a prospective setting. Methods A total 240 patients with liver cirrhosis were included into this cohort study followed for median 17 months. Covert was diagnosed by pathological results Portosystemic Hepatic...
Predictive factors for adverse outcomes in patients with COVID-19 are urgently needed. Data related to the applicability of Clinical Frailty Scale (CFS) risk stratification currently lacking. We investigated ability CFS predict need mechanical ventilation and duration hospital stays European COVID-19. In total, 42 confirmed infection admitted University Medical Center Mainz between March 3 April 15 2020 were included into this validation study data retrospectively analyzed. was assessed at...
Background and aim Body composition has emerged as a prognostic factor for end-stage liver disease. We therefore investigated muscle mass, body fat other clinical–pathological variables predictors of posttransplant survival. Methods A total 368 patients, who underwent orthotopic transplantation (OLT) at our institution, were assessed prior to OLT followed median 9.0 years (range 2.0–10.0 years) after OLT. Psoas, erector spinae the combined paraspinal area, well corresponding indices...
INTRODUCTION: Frailty is a common but often underestimated complication in patients with liver cirrhosis. The Clinical Scale (CFS) allows the assessment of frailty within short period time has only been investigated Canadian cohort outpatients. aim current study was to evaluate ability CFS predict mortality outpatients and nonelectively hospitalized German patients. METHODS: Two hundred 99 cirrhosis were prospectively enrolled. Outpatients/inpatients followed for median 364/28 days regarding...
Abstract Several rapid antigen tests (RATs) for the detection of SARS-CoV-2 were evaluated recently. However, reliable performance data laboratory-based, high-throughput are lacking. Therefore and in response to a short-term shortage PCR reagents, we DiaSorin's LIAISON test comparison RT-qPCR, concerning application screening non-COVID-19 patients on hospital admission. Applying manufacturer-recommended cut-off 200 arbitrary units (AU/mL) specificity Test was 100%, overall analytical...
Health literacy is a concept that refers to patients' ability manage their disease and the health system's guarantee access services. There evidence impacts outcomes of patients with chronic diseases, but detailed information on this topic in liver cirrhosis scarce. It was aim study identify risk factors for poorer cirrhosis.89 were enrolled measured using Literacy Questionnaire (HLQ). Covert hepatic encephalopathy (CHE) diagnosed clinically according West-Haven Criteria (HE grade 1) PHES...
Abstract Hepatic steatosis (HS) related to nonalcoholic fatty liver disease (NAFLD) is increasing globally. In people living with human immunodeficiency virus (PLWH) risk factors of HS are increased. The impact on outcomes and in particular health‐related quality life (HRQL) PLWH remains unknown. aim this cross‐sectional cohort study (FLASH, Prevalence Advanced Fibrosis Patients Living With HIV) was determine the contribution HRQL identify confounders HRQL. A total 245 were prospectively...
Abstract The prevalence of metabolic risk factors and non-alcoholic fatty liver disease (NAFLD) is high among people living with HIV (PLWH). Data on the recently proposed definition dysfunction-associated (MAFLD) in PLWH receiving antiretroviral therapy (ART) remains unknown. A total 282 were included this cross-sectional cohort study. Vibration-controlled transient elastography (VCTE) was used to assess hepatic steatosis fibrosis. MAFLD its subgroups (overweight/obese, lean/normal weight,...
Bacterial infections are associated with a dismal prognosis in patients liver cirrhosis. Data on their prevalence and the pathogen spectra Germany scarce. This study aimed to evaluate impact of bacterial mortality hospitalized cirrhosis analyze multidrug-resistant (MDR) bacteria German tertiary care center.Consecutive, non-electively were enrolled this between 03/2019-06/2021. All underwent clinical, laboratory microbiological testing detect potential infections. Patients followed for 30...
Background: Stratifying patients with liver cirrhosis for risk of rehospitalization is challenging established scoring systems chronic disease. Frailty captures the physical characteristics cirrhosis. Its value predicting short-term rehospitalizations in hospitalized remains to be defined. Methods: Eighty-three non-electively were analyzed this study. was assessed during last 48 h hospital stay frailty index (LFI). Patients followed 30-day rehospitalization. Results: In total, 26 (31%)...
Background ADVanced Organ Support (ADVOS) is a novel type of extracorporeal albumin dialysis and holds promise to sustain liver function recovery patients with acute-on-chronic failure (ACLF). Previously, ADVOS was tested as continuous treatment for intensive care failure. Data related the applicability safety discontinuous outside ICU not available. Aim Evaluation ACLF unit comparison matched historic cohort. Methods results In this retrospective study, 26 indication renal replacement...
Background: ADVanced Organ Support (ADVOS) is a novel type of extracorporeal albumin dialysis that supports multiorgan function in patients with acute-on-chronic liver failure (ACLF). No data exist on whether ADVOS affects inflammatory cytokine levels, which play relevant role ACLF. Aim: Our aim was to quantify levels both before and after single treatment ACLF at regular ward. Methods results: In this prospective study, 15 (60% men) an indication for renal replacement therapy were included....
INTRODUCTION: Frailty is common in patients with cirrhosis and increases the vulnerability to internal external stressors. This study aimed investigate impact of frailty, as defined by Clinical Scale (CFS), on risk acute kidney injury (AKI) hepatorenal syndrome (HRS-AKI) hospitalized liver cirrhosis. METHODS: We analyzed data 201 nonelectively without higher-grade chronic disease. Patient characteristics were captured within first 24 hours hospital admission, frailty was assessed using CFS....
Abstract Methylglyoxal (MGO) is a highly reactive dicarbonyl species that forms advanced glycation end products (AGEs). The binding of these AGEs to their receptor (RAGE) causes and sustains severe inflammation. Systemic inflammation postulated be major driver in the progression liver cirrhosis. However, role circulating MGO levels cirrhosis remains unknown. In this study, we investigated serum two species, glyoxal (GO) using tandem mass spectrometry (HPLC–MS/MS) evaluated association with...
Abstract Purpose Liver-related comorbidities can impair the health-related quality of life (HRQL) in people living with human immunodeficiency virus (HIV) (PLWH). However, role hepatic steatosis and significant fibrosis PLWH remains incompletely characterized. Therefore, aim this study was to explore association on HRQL using medical outcomes HIV health survey (MOS-HIV) PLWH. Methods A total 222 were included final analysis cohort study. Metabolic comorbidities, socioeconomic factors,...
Objectives Loss of muscle quantity and function is associated with frailty reduced quality life. Sonography a simple option to quantify mass, which could be included into routine diagnostic workup. This study was designed prospectively evaluate sonographic measurement compare it established measurements function. Methods Between March 2020 May 2022, 723 patients were enrolled in the study. Psoas area index (PMAI) psoas thickness height (PMTI) quantified. Thigh indices (TMTI) either measured...
Abstract Background The PAGE-B score (Platelet Age GEnder–HBV) selects chronic hepatitis B (cHB) patients showing no relevant 5-year risk for hepatocellular carcinoma (HCC). We, therefore, explored potential cost reduction following the introduction of a tailored ultrasound screening in single center cohort cHB receiving stable antiviral therapy. Methods attending throughout year 2018 were documented. Patients eligible classified into high (≥18 points), intermediate (10–17 points) and low...
Abstract Background : The PAGE-B score (Platelet Age GEnder–HBV) selects chronic hepatitis B (cHB) patients showing no relevant 5-year risk for hepatocellular carcinoma (HCC). We, therefore, explored potential cost reduction following the introduction of a tailored ultrasound screening in cohort cHB receiving stable antiviral therapy. Methods attending throughout year 2018 were documented. Patients eligible classified into high (≥18 points), intermediate (10-17 points) and low (≤9 HCC...