A5006811577- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- COVID-19 Clinical Research Studies
- Drug-Induced Hepatotoxicity and Protection
- Long-Term Effects of COVID-19
- Electrolyte and hormonal disorders
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Cancer Genomics and Diagnostics
- Body Composition Measurement Techniques
- Esophageal Cancer Research and Treatment
- Nutrition and Health in Aging
- AI in cancer detection
- Respiratory Support and Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Diseases and Glomerulopathies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Acute Myocardial Infarction Research
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Inflammatory Bowel Disease
- Melanoma and MAPK Pathways
Johannes Gutenberg University Mainz
2016-2025
University Medical Center of the Johannes Gutenberg University Mainz
2017-2025
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2014-2024
The Royal Melbourne Hospital
2020
The University of Melbourne
2020
St. Vincenz-Krankenhaus Limburg
2016
St. Elisabeth-Hospital Bochum
2009
Studies on the effect of computer-aided detection (CAD) in a daily clinical screening and surveillance colonoscopy population practice are scarce. The aim this study was to evaluate novel CAD system population.
Coronavirus disease 19 (COVID-19)-associated coagulopathy is a hallmark of severity and poor prognosis. The key manifestations this prothrombotic syndrome-microvascular thrombosis, stroke, venous pulmonary clots-are also observed in severe catastrophic antiphospholipid syndrome. Antiphospholipid antibodies (aPL) are detectable COVID-19 patients, but their association with the clinical course remains unproven.
Background Linked color imaging (LCI) has been shown to be effective in multiple randomized controlled trials for enhanced colorectal polyp detection. Recently, artificial intelligence (AI) with deep learning through convolutional neural networks dramatically improved and is increasingly recognized as a promising new technique enhancing Aim This study aims evaluate newly developed computer-aided detection (CAD) system combination LCI Methods First, network was trained the using dataset of...
Abstract Background This prospective multicenter study funded by the DEGUM assesses diagnostic accuracy of standardized contrast-enhanced ultrasound (CEUS) for noninvasive diagnosis hepatocellular carcinoma (HCC) in high-risk patients. Methods Patients at high risk HCC with a histologically proven focal liver lesion on B-mode were recruited prospectively approach. Clinical and imaging data entered via online entry forms. The accuracies compared conventional interpretation CEUS time...
Background An increasing level of evidence suggests that obesity not only is a major risk factor for cardiovascular diseases (CVDs) but also has adverse outcomes during COVID-19 infection. Methods We used the German nationwide inpatient sample to analyze all hospitalized patients with confirmed diagnosis in Germany from January December 2020 and stratified them diagnosed obesity. Obesity was defined as body mass index ≥30 kg/m 2 according WHO. The impact on in-hospital case fatality events...
To date, the cornerstone of treatment in patients with advanced or metastatic cholangiocarcinoma (CCA) is systemic chemotherapy based on a combination gemcitabine and platinum derivative. Other therapeutic approaches including targeted agents tyrosine kinase inhibitors (TKI) have demonstrated disappointing results, highlighting complexity CCA. Recently, drugs aiming at inhibition HER-receptors shown first benefit late stage disease. The aim this phase I study was to test dose level...
In patients with pulmonary embolism (PE), the impact of diabetes mellitus on patient profile and outcome is not well investigated.
Background: Coronavirus disease-2019 (COVID-19) triggers systemic infection with involvement of the respiratory tract. There are some patients developing haemostatic abnormalities during their a considerably increased risk death. Materials and Methods: Patients (n = 85) SARS-CoV-2 attending University Medical Center, Mainz, from 3 March to 15 May 2020 were retrospectively included in this study. Data regarding demography, clinical features, treatment laboratory parameters analyzed. Twenty...
Background: Diabetes mellitus (DM) represents a relevant risk factor regarding morbidity and mortality worldwide. However, only limited data exist the impact of DM on clinical outcome patients with COVID-19 infection. Methods: All hospitalized confirmed COVID-19-infection (ICD-code U07.1) during year 2020 in Germany were included present study. Patients stratified co-prevalence (ICD-codes E10-E14), in-hospital case fatality adverse events was analyzed. Results: Overall, 176,137...
<b>Hintergrund und Fragestellung:</b> Die Leberzirrhose entsteht als Komplikation Endstadium chronischer Lebererkrankungen. Der klinische Verlauf ist wesentlich von der Ätiologie Grunderkrankung den begleitenden Risikofaktoren abhängig. Wir haben Ätiologie, klinischen Therapie Patienten mit an unserem Zentrum analysiert, um für Infektionen zu identifizieren. <b>Methodik:</b> Nach standardisierter Erfassung ambulanter erfolgte eine retrospektive Auswertung über 20 Monaten (Juli 2012 – Februar...
<b>Hintergrund und Fragestellung | </b>Das hepatorenale Syndrom (HRS) ist eine schwere, potenziell reversible Komplikation bei Patienten mit Leberzirrhose. Unbehandelt die Prognose sehr schlecht. Für Behandlung Terlipressin in Kombination Humanalbumin wurde mehreren randomisiert-kontrollierten Studien Verbesserung der Nierenfunktion demonstriert, Einfluss dieser Therapie auf Gesamtprognose bleibt allerdings unklar. Im Rahmen vorliegenden Observations-Studie sollte Effekt einer...
The only curative approach in pancreatic ductal adenocarcinoma (PDAC) is resection, which possible 15 - 30 % of patients. Local tumor spread or distant metastases are contraindications for resection the majority Surgical-oncological quality with short- and long-term results varying tremendously, so that "expertise/quality" associated to hospital- surgeon's volume and/or center formation. treatment also depend, a great extent, on medical diagnostic quality. With our retrospective study, we...
Abstract Immune thrombotic thrombocytopenic purpura (iTTP) is a rare autoimmune disorder characterized by severely reduced activity of the von Willebrand factor (VWF)-cleaving protease ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) due to autoantibodies. This leads development pathogenic multimers VWF, causing microangiopathy decreased number platelets, hemolysis, life-threatening tissue ischemia mostly brain, heart, kidneys. Standard treatment...
Abstract Funding Acknowledgements None. Background In December 2019 first patient-cases of pneumonia caused by an unknown virus were detected in Wuhan, China. From this day on, SARS-CoV-2 spread throughout the world with enormous pace causing deadliest pandemic twenty-first century. First infection cases Germany reported at end January 2020 Bavaria and sustained transmission resulted also a strong COVID-19 population. Although children young people aged ≤18 years represent approximately...
Objectives Loss of muscle quantity and function is associated with frailty reduced quality life. Sonography a simple option to quantify mass, which could be included into routine diagnostic workup. This study was designed prospectively evaluate sonographic measurement compare it established measurements function. Methods Between March 2020 May 2022, 723 patients were enrolled in the study. Psoas area index (PMAI) psoas thickness height (PMTI) quantified. Thigh indices (TMTI) either measured...
Background/Aim: Prognoses of patients receiving radio-chemotherapy with 5-fluorouracil (5-FU) and cisplatin for unresectable esophageal cancer may be improved the addition cetuximab. This phase I study aimed to define maximum tolerated dose 5-FU when combined cisplatin, cetuximab radiotherapy. Patients Methods: Treatment included 59.4 Gy radiotherapy concurrently two courses (20 mg/m<sup>2</sup>, d1-4) (dose level 0: 500 1: 750 d1-4; 2: 1,000 d1-4), followed by chemotherapy. Cetuximab was...
The Ambulatory Management of COVID-19 Via the German Department HealthMost cases SARS-CoV-2 infection present mild to moderate symptoms that do not require inpatient treatment (1).In Germany, resident doctors and health authorities are responsible for monitoring management outpatient cases; extent personnel expenditure is yet known.We report on systematic patients with by Health Mainz-Bingen.The aim this work was determine proportion outpatients as well in time labor required case contact tracking.