A5075514559- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Electrolyte and hormonal disorders
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- IgG4-Related and Inflammatory Diseases
- Esophageal Cancer Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Helicobacter pylori-related gastroenterology studies
- Liver Diseases and Immunity
- Cancer, Lipids, and Metabolism
- Muscle metabolism and nutrition
- Lung Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Surgical Treatments
- Eosinophilic Esophagitis
- Hepatitis Viruses Studies and Epidemiology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Medical and Health Sciences Research
- Infrared Thermography in Medicine
University Medical Center of the Johannes Gutenberg University Mainz
2012-2024
Johannes Gutenberg University Mainz
2014-2024
Kempten University of Applied Sciences
2022-2023
Klinikverbund Südwest
2022
Klinikum Osnabrück
2019-2021
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2012-2020
Helios Dr. Horst Schmidt Kliniken Wiesbaden
2007-2008
Colonoscopy is the accepted gold standard for screening of neoplastic colorectal lesions, but substantial miss rate remains a challenge. Computed virtual chromoendoscopy with Fujinon intelligent colour enhancement (FICE) system new dyeless imaging technique that might allow higher rates adenoma detection.This prospective randomised five tertiary care centre trial colonoscopy in FICE mode versus targeted indigocarmine chromoscopy (control group) consecutive patients attending routine...
OBJECTIVES Standard colonoscopy offers no reliable discrimination between neoplastic and nonneoplastic colorectal lesions. Computed virtual chromoendoscopy with the Fujinon intelligent color enhancement (FICE) system is a new dyeless imaging technique that enhances mucosal vascular patterns. This prospective trial compared feasibility of FICE, standard colonoscopy, conventional indigo carmine in low-and high-magnification modes for determination colonic lesion histology. METHODS Sixty-three...
Minimal hepatic encephalopathy (HE) and HE grade 1 (HE1) according to the West Haven criteria have recently been grouped as one entity named-covert HE- (CHE). Data regarding impact of CHE on health-related quality life (HRQoL) sleep are controversial.First, determine whether affects HRQoL cirrhotic patients second, minimal (MHE) HE1 affect a comparable extent.A total 145 consecutive were enrolled. was diagnosed clinically criteria. Critical flicker frequency Psychometric Hepatic...
See also: Commentaire de travail J. Pohl et al., pp. 594Endoscopy 2007; 39(07): 757-757DOI: 10.1055/s-0032-1306950
Patients with liver cirrhosis often suffer from complications such as ascites, gastrointestinal bleeding, and infections, resulting in impaired quality of life. Frequently, the close relatives patients also a lower life chronic diseases. In recent years, acute-to-chronic failure has been defined separate entity high mortality. Often several organs are affected which makes intensive care therapy necessary. Little is known about influence acute-on-chronic-liver (ACLF) on psychosocial burden...
Background: Current EASL/AASLD guidelines recommend treatment of covert hepatic encephalopathy (HE) only in symptomatic patients, for example, those with impaired quality life or affected driving abilities. Goals: Because testing is time consuming, the aim present study was to identify simple clinical predictors poor patients HE (CHE). Study: In total, 139 cirrhotic in- and outpatients without a history overt were enrolled. Diagnosis grade 1 (HE1) diagnosed clinically according West-Haven...
Hepatorenal syndrome (HRS) is associated with a poor prognosis. In HRS type 1, loss of renal function rapidly progressive, while 2 characterised by chronic ascites and more moderately elevated parameters. While treatment terlipressin/albumin well established in its effectiveness less clear.
Patients with liver cirrhosis suffer from significantly reduced health-related quality of life and are often dependent on support caregivers. In this context, caregivers impaired (QoL) as well psychosocial burden (PB). The aim the present study was to identify factors influencing QoL PB in order improve social care patients caregivers.In cross-sectional study, 106 their were included. (Health-related) surveyed (CLDQ) (SF-36) determined by Zarit Burden Interview.Alcohol related (55%)...
Hepatocellular carcinoma in non-hepatitis B virus endemic areas is rare patients younger than 40 years of age. The aim this study was to characterize young a large German cohort comparison with older regard underlying liver disease, clinical management, and survival.We analyzed the data medical records 1108 consecutive confirmed hepatocellular carcinoma. Twenty-five (2%) were We compared subgroup age.Underlying chronic disease less common detectable only 56% patients. Fibrolamellar more...
Die Gastroparese ist eine häufige, aber unter Umständen schwerwiegende Erkrankung, die sich entweder idiopathisch oder als Folge einer Vielzahl von Grunderkrankungen manifestieren kann, am häufigsten auf dem Boden eines Diabetes mellitus nach operativen Eingriffen im Oberbauch. Seltenere Ursachen dieser gastralen Motilitätsstörung wie Kollagenosen ein paraneoplastischer Ursprung müssen ebenfalls in Betracht gezogen werden. Wir berichten über einen 73-jährigen Patienten, der uns mit schweren...
Nonerosive reflux disease (NERD) is commonly diagnosed in patients with symptoms of reflux. The aim the present study was to determine whether high-definition endoscopy (HD) plus equipped iScan function or chromoendoscopy Lugol's solution might permit differentiation NERD from those without symptoms, proven by targeted biopsies endoscopic lesions. A total 100 regular intake proton pump inhibitors and a normal conventional upper were prospectively divided into controls. second performed using...
IgG4-related disease has gained increased attention worldwide. While the initial focus was on autoimmune pancreatitis which first described in Asian populations and turned out to be of relevance Western too, scope recently broadened towards a notion multi-systemic with very diverse manifestations such as pancreatitis, sclerosing cholangitis (IgG4-SC), retroperitoneal fibrosis tubulointerstitial nephritis. IgG4-SC (also known IgG4-associated cholangitis, IAC) represents rare but clinically...
<b>Hintergrund und Fragestellung:</b> Die Leberzirrhose entsteht als Komplikation Endstadium chronischer Lebererkrankungen. Der klinische Verlauf ist wesentlich von der Ätiologie Grunderkrankung den begleitenden Risikofaktoren abhängig. Wir haben Ätiologie, klinischen Therapie Patienten mit an unserem Zentrum analysiert, um für Infektionen zu identifizieren. <b>Methodik:</b> Nach standardisierter Erfassung ambulanter erfolgte eine retrospektive Auswertung über 20 Monaten (Juli 2012 – Februar...
<b>Hintergrund und Fragestellung | </b>Das hepatorenale Syndrom (HRS) ist eine schwere, potenziell reversible Komplikation bei Patienten mit Leberzirrhose. Unbehandelt die Prognose sehr schlecht. Für Behandlung Terlipressin in Kombination Humanalbumin wurde mehreren randomisiert-kontrollierten Studien Verbesserung der Nierenfunktion demonstriert, Einfluss dieser Therapie auf Gesamtprognose bleibt allerdings unklar. Im Rahmen vorliegenden Observations-Studie sollte Effekt einer...
IgG4-related disease has gained increased attention worldwide. While the initial focus was on autoimmune pancreatitis which first described in Asian populations and turned out to be of relevance Western too, scope recently broadened towards a notion multi-systemic with very diverse manifestations such as pancreatitis, sclerosing cholangitis (IgG4-SC), retroperitoneal fibrosis tubulointerstitial nephritis. IgG4-SC (also known IgG4-associated cholangitis, IAC) represents rare but clinically...
Abstract Background and aims Hepatorenal syndrome is a major complication in patients with cirrhosis associated high mortality. Predictive biomarkers for therapy response are largely missing. Cytokeratin18‐based cell death markers significantly elevated complications of chronic liver disease, but the role these HRS treated vasoconstrictors albumin unknown. Methods We prospectively analyzed total 138 HRS, without acute kidney injury at University Medical Center Mainz between April 2013 July...
See also: Commentaire de travail J. Pohl et al., pp. 883Endoscopy 2008; 40(11): 1057-1057DOI: 10.1055/s-0032-1306882
In general practitioner care, abnormal liver chemistries are often being diagnosed unintentionally. So far, there is no evidence-based, structured diagnostic pathway for classifying and evaluating elevated enzymes, especially with regard to the early detection of patients at increased risk fibrosis or cirrhosis. Accordingly, dealing values which noticed in course a blood examination challenge that strongly depends on doctor's approach.In survey, 391 practitioners Rhineland-Palatinate...
Abstract Background Suspected gastrointestinal (GI) bleeding is a common initial diagnosis in emergency departments. Despite existing endoscopic scores to estimate the risk of GI bleeding, primary clinical assessment urgency can remain challenging. The 5-step Manchester Triage System (MTS) validated score that often applied for patients presenting Methods All computer-based records who were admitted between January 2014 and December our department tertiary referral hospital analyzed...