A5015569467- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver Diseases and Immunity
- Autoimmune Neurological Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Corporate Governance and Management
- Esophageal and GI Pathology
- Flexible and Reconfigurable Manufacturing Systems
- Biochemical effects in animals
- Genetic factors in colorectal cancer
- Peripheral Neuropathies and Disorders
- Pancreatitis Pathology and Treatment
- Corporate Governance and Law
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Liver physiology and pathology
- Metabolism and Genetic Disorders
- Digital Innovation in Industries
- Genetics and Neurodevelopmental Disorders
- Colorectal Cancer Treatments and Studies
- Electrolyte and hormonal disorders
- DNA Repair Mechanisms
- Multiple and Secondary Primary Cancers
- Drug-Induced Hepatotoxicity and Protection
Klinikum Osnabrück
2022-2025
University Medical Center of the Johannes Gutenberg University Mainz
2017-2022
Johannes Gutenberg University Mainz
2011-2022
University Hospital Schleswig-Holstein
2021
University of Lübeck
2021
Medizinische Hochschule Hannover
2021
Jena University Hospital
2021
Heinrich Heine University Düsseldorf
2021
Institute of Neuroimmunology of the Slovak Academy of Sciences
2021
Universität Hamburg
2021
Anti-IgLON5 disease is a newly defined clinical entity characterized by progressive course with high disability and mortality rate. While precise pathogenetic mechanisms remain unclear, features characteristic of both autoimmune neurodegenerative diseases were reported. Data on immunotherapy are limited, its efficacy remains controversial. In this study, we retrospectively investigated an anti-IgLON5 cohort special focus clinical, serological genetic predictors the response long-term...
Summary Background Advanced fibrosis has been established as the most important predictor of overall mortality in patients with non‐alcoholic fatty liver disease ( NAFLD ). In contrast to cirrhosis, advanced, non‐cirrhotic is difficult identify and data from Germany are lacking. Aim To clinical factors associated fibrosis. Methods Patients were recruited prospectively enrolling European Registry. Clinical characteristics performance non‐invasive surrogate scores compared vibration‐controlled...
Nonalcoholic fatty liver disease (NAFLD), depression, and anxiety disorders are frequent diseases, data on mutual influence inconsistent. The aim of this study was to explore the incidence depression in a large primary care cohort Germany impact NAFLD over 10-year time frame. Patients with diagnosed between 2010 2015 were matched without controlling for age, sex, physician, index year, Charlson comorbidity index. outcome anxiety, first prescription antidepressant drugs. We compared 19,871...
Systemic inflammation is a driving force for the development of hepatic encephalopathy and recent studies demonstrated that elevated Interleukin-6 (IL-6) serum levels are associated with presence minimal in patients liver cirrhosis.To test hypothesis IL-6 suitable marker to identify cirrhosis at high risk overt encephalopathy.201 were included into this prospective cohort study followed mean time 322 days. Covert was diagnosed according West-Haven criteria (hepatic grade 1) portosystemic...
Abstract Autoantibodies against contactin-associated protein 2 (Caspr2) not only induce limbic autoimmune encephalitis but are also associated with pain conditions. Here, we analyzed clinical data on in a large cohort of patients included into the German Network for Research Autoimmune Encephalitis. Out 102 our cohort, was frequent symptom (36% all patients), often severe (63.6% pain) and/or even major (55.6% pain). Pain phenotypes differed between patients. Cluster analysis revealed two...
Abstract Background and objectives Corticosteroids or plasma exchange are recommended for acute treatment of autoimmune encephalitis (AE). Intravenous immunoglobulins (IVIG) suggested as an additional option but data on effect is scarce. The objective the present study was to investigate impact first-line three most common forms AE, in particular, evaluate IVIG therapy these diseases. Methods A total 1274 patients from German Network Autoimmune Encephalitis Research (GENERATE) were analyzed,...
OBJECTIVES: Diagnosis of covert hepatic encephalopathy (CHE) is challenging and often neglected in clinical practice. The aim this study was to develop an easy-to-perform score predict CHE patients with cirrhosis. METHODS: For the development or validation cohort proposed score, 142 96 consecutive cirrhosis were prospectively enrolled. Psychometric Hepatic Encephalopathy Score used detect minimal encephalopathy. All examined simplified animal naming test asked complete Chronic Liver Disease...
Cardiovascular disease (CVD) is the leading cause of death in patients with nonalcoholic fatty liver (NAFLD). The current analysis expands knowledge on atherogenic lipid profiles NAFLD by modeling changes low-density lipoprotein cholesterol (LDL-C) and total (TC) a prospectively enrolling real-life study cohort to inform physicians cardiovascular (CV) event risk based these changes. A 304 histologically confirmed were included (mean age, 52 years; equal sex distribution). Of these, 129...
INTRODUCTION: Despite the negative impact of covert hepatic encephalopathy on outcome patients with liver cirrhosis, data regarding ability different testing strategies to predict overt (OHE) development and mortality are limited. This study aimed compare Psychometric Hepatic Encephalopathy Score (PHES), critical flicker frequency (CFF), simplified animal naming test (S-ANT1), clinical (CCHE) score OHE mortality. METHODS: A total 224 cirrhosis were tested prospectively followed up clinically...
To investigate the genetic determinants of most common type antibody-mediated autoimmune encephalitis, anti-NMDA receptor (anti-NMDAR) encephalitis.We performed a genome-wide association study in 178 patients with anti-NMDAR encephalitis and 590 healthy controls, followed by colocalization analysis to identify putatively causal genes.We identified 2 independent risk loci harboring significant variants (p < 5 × 10-8, OR ≥ 2.2), 1 on chromosome 15, only LRRK1 gene, 11 centered ACP2 NR1H3 genes...
Patients with liver cirrhosis often suffer from complications such as ascites, gastrointestinal bleeding, and infections, resulting in impaired quality of life. Frequently, the close relatives patients also a lower life chronic diseases. In recent years, acute-to-chronic failure has been defined separate entity high mortality. Often several organs are affected which makes intensive care therapy necessary. Little is known about influence acute-on-chronic-liver (ACLF) on psychosocial burden...
Background: Current EASL/AASLD guidelines recommend treatment of covert hepatic encephalopathy (HE) only in symptomatic patients, for example, those with impaired quality life or affected driving abilities. Goals: Because testing is time consuming, the aim present study was to identify simple clinical predictors poor patients HE (CHE). Study: In total, 139 cirrhotic in- and outpatients without a history overt were enrolled. Diagnosis grade 1 (HE1) diagnosed clinically according West-Haven...
Hepatorenal syndrome (HRS) is associated with a poor prognosis. In HRS type 1, loss of renal function rapidly progressive, while 2 characterised by chronic ascites and more moderately elevated parameters. While treatment terlipressin/albumin well established in its effectiveness less clear.
Cholestatic liver injury results from impaired bile flow or metabolism and promotes hepatic inflammation fibrogenesis. Toxic acids that accumulate in cholestasis induce apoptosis contribute to early cholestatic injury, which is amplified by accompanying inflammation. The aim of the current study was evaluate role antiapoptotic caspase 8-homolog cellular FLICE-inhibitory (cFLIP) protein during acute injury. Transgenic mice exhibiting hepatocyte-specific deletion cFLIP (cFLIP −/− ) were used...
Background: Gastric cancer is common malignancy and exhibits a poor prognosis. At the time of diagnosis, majority patients present with metastatic disease which precludes curative treatment. Non-invasive biomarkers discriminate early from advanced stages or predict response to treatment are urgently required. This study explored cytokeratin-18 fragment M30 full-length M65 in predicting survival randomized, placebo-controlled trial gastric cancer. Methods: Patients enrolled SUN-CASE received...
Background ADVanced Organ Support (ADVOS) is a novel type of extracorporeal albumin dialysis and holds promise to sustain liver function recovery patients with acute-on-chronic failure (ACLF). Previously, ADVOS was tested as continuous treatment for intensive care failure. Data related the applicability safety discontinuous outside ICU not available. Aim Evaluation ACLF unit comparison matched historic cohort. Methods results In this retrospective study, 26 indication renal replacement...