A5069350538- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Dementia and Cognitive Impairment Research
- Stroke Rehabilitation and Recovery
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Traumatic Brain Injury and Neurovascular Disturbances
- Dialysis and Renal Disease Management
- Pharmacological Effects and Toxicity Studies
- Sympathectomy and Hyperhidrosis Treatments
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Reproductive tract infections research
- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Advanced Neuroimaging Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Cerebral Venous Sinus Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Biosimilars and Bioanalytical Methods
- Neurological Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurosurgical Procedures and Complications
Technical University of Munich
2013-2024
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2003-2024
Asklepios Neurologische Klinik Falkenstein
2021-2023
Centre National de la Recherche Scientifique
2023
University Medical Center Hamburg-Eppendorf
2023
St. Josef-Hospital
2023
Universität Hamburg
2023
Ruhr University Bochum
2023
Medizinische Hochschule Hannover
2023
Inn-Salzach-Klinikum
2016-2020
Tinnitus is a common but poorly understood disorder characterized by ringing or buzzing in the ear. Central mechanisms must play crucial role generating this auditory phantom sensation as it persists most cases after severing nerve. One hypothesis states that tinnitus caused reorganization of tonotopic maps cortex, which leads to an overrepresentation frequencies. Moreover, participation limbic system has been postulated. Here we aimed at identifying brain areas display structural change...
Background: Data regarding the relationship between physical activity and cognitive impairment are limited controversial.We examined whether is associated with incident during follow-up.Methods: As part of a community-based prospective cohort study in southern Bavaria, Germany, 3903 participants older than 55 years were enrolled 2001 2003 followed up for 2 years.Physical (classified as no activity, moderate [Ͻ3 times/ wk], high [Ն3 times/wk]), function (assessed by 6-Item Cognitive...
Background and Purpose— Recent studies described an association between elevated levels of C-reactive protein (CRP) outcome after ischemic stroke. We investigated the impact early serial CRP measurements in hyperacute stroke on long-term outcome. Methods— One hundred twenty-seven consecutive patients without thrombolysis with a first no more than 12 hours symptom onset were examined. Serial done at admission (CRP 1), within 24 2), 48 3) onset. In addition to several cerebrovascular risk...
To evaluate the prognostic impact of early pathologic sympathetic activation after stroke.The authors examined 112 consecutive patients (mean age, 69 years; 60 men) with their first brain infarction. A was presumed if initial norepinephrine level exceeds 300 pg/mL. In addition, involvement insular cortex, nighttime blood pressure changes, and several cardiovascular risk factors were determined. One-year outcome measures mortality rate, cerebrovascular events, activities daily living (Barthel...
<b>Background:</b> Primary blepharospasm is a focal dystonia characterised by excessive involuntary closure of the eyelids. The pathophysiology primary unresolved. <b>Aim:</b> To pinpoint grey-matter changes that are associated with blepharospasm. <b>Methods:</b> 16 right-handed patients (mean age 67.4 (SD 4.3) years; 12 women) were compared healthy volunteers matched for sex and age. High-resolution T1-weighted magnetic resonance imaging each participant was obtained analysed voxel-based...
The prognostic value of cardiac troponins and natriuretic peptide in acute ischemic stroke is uncertain. We measured troponin T (cTnT), I (cTnI), N-terminal pro-brain (NT-proBNP) at admission patients without evident myocardial damage.In 174 consecutive with MRI-confirmed stroke, serial measurements cTnT, cTnI, NT-proBNP were performed 3 different time points the hyperacute phase (at admission, on days 1 2). Relation laboratory values to risk factors, subtype classification, clinical outcome...
Background. Limited data exist regarding the relationship between decreased renal function and cognitive impairment. Methods. A total of 3679 participants Intervention Project on Cerebrovascular Diseases Dementia in Community Ebersberg (INVADE) composed community-based cohort study. Measures were estimated using Cockcroft–Gault equation divided into normal, mild moderate-to-severe impaired (creatinine clearance ≥60, 45–59 <45 mL/min/1.73 m2, respectively). The main outcome measures...
Atrial fibrillation (AF) is the most frequent risk factor in ischemic stroke but often remains undetected. We analyzed value of insertable cardiac event recorder detection AF a 1-year cohort patients with cryptogenic stroke.All and eligibility for oral anticoagulation were offered insertion recorder. Regular follow-up 1 year recorded incidence AF.Of 393 stroke, 65 (16.5%) had 22 eligible patients, an was inserted. After year, 6 (27.3%), detected.These preliminary data show that approximately...
Abstract Autoantibodies against contactin-associated protein 2 (Caspr2) not only induce limbic autoimmune encephalitis but are also associated with pain conditions. Here, we analyzed clinical data on in a large cohort of patients included into the German Network for Research Autoimmune Encephalitis. Out 102 our cohort, was frequent symptom (36% all patients), often severe (63.6% pain) and/or even major (55.6% pain). Pain phenotypes differed between patients. Cluster analysis revealed two...
Abstract Objectives Increased carotid intima‐media thickness (C‐IMT) is a non‐invasive marker of atherosclerosis and predicts vascular events. Moreover, increasing evidence suggests an association between cognitive decline. The purpose this study to investigate the relationship C‐IMT development impairment in large population‐based sample. Methods This was based on data participants INVADE (Intervention project cerebrovascular diseases dementia district Ebersberg, Bavaria) project. Vascular...
Chronic kidney disease (CKD) has evolved as a possible new determinant of cognitive decline and dementia. This review outlines the presumed pathophysiology in CKD, which consists traditional vascular risk factors well nonvascular metabolic biochemical abnormalities within central nervous system caused by CKD. The recent major cross-sectional studies longitudinal - including one meta-analysis that mostly suggest an association CKD are discussed. Finally, potential therapeutic strategies presented.
Diffusion-weighted imaging (DWI) has been established to diagnose acute cerebral ischemia. Signal intensity changes occur not only in patients with definite stroke but also up 67% of transient ischemic attack (TIA) patients. We investigated the predictive value DWI signal distinguish between TIA and stroke.Clinical data, conventional magnetic resonance (MRI), were collected 60 consecutive 37 stroke. was performed within 24 hours after symptom onset. Using an image analyzing system, we...
Chlamydia pneumoniae (Cp) infection has been associated with atherosclerosis, and a beneficial effect of antibiotic therapy on future cardiovascular events was described.We evaluated the roxithromycin (150 mg twice daily for 30 days) progression intima-to-media thickness (IMT) common carotid artery using duplex ultrasonography in prospective randomized trial follow-up 2 years 272 consecutive patients ischemic stroke aged over 55 whom first IMT measurement Cp testing (IgG IgA) were performed...
<b>BACKGROUND AND PURPOSE:</b> Voxel-based morphometry (VBM) has proved a powerful method to detect subtle changes of gray matter (GM) at the group level but role VBM for detection GM in single subjects, especially those with suspected neurodegenerative disorder, remains uncertain. Here, we performed subject analyses 22 patients early stages Huntington disease (HD), disorder well-known and characteristic pattern loss. <b>MATERIALS METHODS:</b> We applied an ANCOVA age gender as covariates...
Improving cardiovascular health possibly decreases the risk of dementia. Primary care practices offer a suitable setting for monitoring and controlling factors in older population. The purpose study is to examine association metric including six behaviors blood parameters with dementia primary patients. Participants (N = 3547) were insurants aged ≥55 largest German statutory insurance company, who enrolled six-year prospective population-based study. Smoking, physical activity, body mass...