A5036055961- Vestibular and auditory disorders
- Autoimmune Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- Ophthalmology and Eye Disorders
- Peripheral Neuropathies and Disorders
- Epilepsy research and treatment
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Herpesvirus Infections and Treatments
- Meningioma and schwannoma management
- Pharmacological Effects and Toxicity Studies
- Mosquito-borne diseases and control
- Visual perception and processing mechanisms
- Infectious Encephalopathies and Encephalitis
- Glaucoma and retinal disorders
- Atrial Fibrillation Management and Outcomes
- Genetics and Neurodevelopmental Disorders
- Psychiatric care and mental health services
- Cytomegalovirus and herpesvirus research
- Vector-borne infectious diseases
- Tactile and Sensory Interactions
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroscience of respiration and sleep
- Vascular Malformations Diagnosis and Treatment
- RNA regulation and disease
Evangelische Kliniken Gelsenkirchen
2023-2024
Johannes Kepler University of Linz
2018-2024
Charles University
2024
Kepler Universitätsklinikum
2017-2024
University of Duisburg-Essen
2024
The University of Melbourne
2017-2018
The Royal Melbourne Hospital
2018
Ludwig-Maximilians-Universität München
2007-2014
Université Clermont Auvergne
2011
Heidelberg University
1985-2008
Importance Acute symptomatic seizures occurring within 7 days after ischemic stroke may be associated with an increased mortality and risk of epilepsy. It is unknown whether the type acute seizure influences this risk. Objective To compare epilepsy following different types seizures. Design, Setting, Participants This cohort study analyzed data acquired from 2002 to 2019 9 tertiary referral centers. The derivation included adults cohorts 2 case-control studies neuroimaging-confirmed without...
Downbeat nystagmus (DBN) is the most common form of acquired involuntary ocular oscillation overriding fixation. According to previous studies, cause DBN unsolved in up 44% cases. We reviewed 117 patients establish whether analysis a large collective and improved diagnostic means would reduce number cases with "idiopathic DBN" thus change aetiological spectrum.The medical records all diagnosed our Neurological Dizziness Unit between 1992 2006 were reviewed. In final analysis, only those...
Objective The purpose of this study was to identify risk factors for acute symptomatic seizures and post‐stroke epilepsy after ischemic stroke evaluate the effects reperfusion treatment. Methods We assessed using logistic or Cox regression in a multicenter study, including adults from 8 European referral centers with neuroimaging‐confirmed stroke. compared between participants without treatment following propensity score matching reduce confounding due selection. Results In overall cohort...
Anti-amyloidogenic processing of the amyloid precursor protein APP by α-secretase prevents formation amyloid-β peptide, which accumulates in senile plaques Alzheimer disease patients. α-Secretase belongs to family a disintegrin and metalloproteases (ADAMs), ADAM10 is primary candidate for this anti-amyloidogenic activity. We recently demonstrated that translation repressed its 5'-UTR particular first half responsible translational repression. Here, we asked whether specific sequence motifs...
<h3>Background and Objectives</h3> CSF in antibody-defined autoimmune encephalitis (AE) subtypes shows subtype-dependent degrees of inflammation ranging from rare often mild to frequent robust. AEs with NMDA receptor antibodies (NMDAR-E) leucine-rich glioma-inactivated protein 1 (LGI1-E) represent opposite ends this spectrum: NMDAR-E typically frequent/robust LGI1-E rare/mild inflammation. For a more in-depth analysis, we characterized findings acute, therapy-naive multicentric,...
Abstract Autoantibodies against contactin-associated protein 2 (Caspr2) not only induce limbic autoimmune encephalitis but are also associated with pain conditions. Here, we analyzed clinical data on in a large cohort of patients included into the German Network for Research Autoimmune Encephalitis. Out 102 our cohort, was frequent symptom (36% all patients), often severe (63.6% pain) and/or even major (55.6% pain). Pain phenotypes differed between patients. Cluster analysis revealed two...
Neurologic disorders in which the etiology and pathogenesis are not yet understood termed idiopathic. Downbeat nystagmus (DBN) is a frequent eye movement disorder that clinically manifests with oscillopsia postural instability. Forty percent of patients DBN classified as having idiopathic DBN, because no underlying pathology can be demonstrated by conventional MRI or laboratory tests.We evaluated gray matter brain volumes 11 compared them to those healthy controls using voxel-based...
Caldesmon induces inhibition of MG 2+ ‐ATPase activity actomyosin and relaxation skinned fibers chicken gizzard smooth muscle without influencing the level myosin light chain‐1 phosphorylation. Both these effects are reversed by calmodulin at a high molar excess over caldesmon in presence Ca .
The hippocampal formation, including the parahippocampal gyrus, is known to be involved in different aspects of navigation and spatial orientation. Recently, bilateral activation during mental imagery walking running was demonstrated fMRI. For current study question whether distinct functional regions within formation could defined from analysis brain activity stance locomotion healthy, blind, vestibular‐loss subjects. Using same experimental paradigm all groups (fMRI after training actual...
Patients with progressive supranuclear palsy (PSP) fall frequently, beginning early in the course of their disease. Abnormal vestibulospinal reflexes are suspected, but angular vestibulo-ocular reflex, which is mediated by labyrinthine semicircular canals, survives late into disease.To test hypothesis that otolithic-mediated abnormal PSP.We tested otolith-ocular (the translational reflex [tVOR]) during combined rotation-translation nine patients PSP and age-matched control subjects; subjects...
Patients with vestibular schwannoma (VS) frequently suffer from disabling symptoms. This prospective follow-up study evaluates and auditory function impairment of quality life due to vertigo, dizziness, imbalance in patients unilateral VS different sizes before/after microsurgical or radiosurgical treatment.Thirty-eight were included. Twenty-two received microsurgery, 16 CyberKnife radiosurgery. Two follow-ups took place after a median 50 186.5 days. standardized neuro-ophthalmological...
Background: The differential diagnosis of autoimmune and infectious encephalitis is notoriously difficult. For this study, we compare the presenting clinical symptoms paraclinical test results patients. A algorithm for has recently been published. We these Graus criteria on our cohort diagnostic sensitivity specificity within first week presentation. Methods: included all patients seen at department a 10-year-period who were diagnosed with encephalitis. discharge diagnoses served as...
To investigate the genetic determinants of most common type antibody-mediated autoimmune encephalitis, anti-NMDA receptor (anti-NMDAR) encephalitis.We performed a genome-wide association study in 178 patients with anti-NMDAR encephalitis and 590 healthy controls, followed by colocalization analysis to identify putatively causal genes.We identified 2 independent risk loci harboring significant variants (p < 5 × 10-8, OR ≥ 2.2), 1 on chromosome 15, only LRRK1 gene, 11 centered ACP2 NR1H3 genes...
Background In addition to other stroke-related deficits, the risk of seizures may impact driving ability after stroke. Methods We analysed data from a multicentre international cohort, including 4452 adults with acute ischaemic stroke and no prior seizures. calculated Chance Occurrence Seizure in next Year (COSY) according SeLECT 2.0 prognostic model. considered COSY<20% safe for private <2% professional driving, aligning commonly used cut-offs. Results risks year were mainly...