A5028347590- Vestibular and auditory disorders
- Visual perception and processing mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Ophthalmology and Eye Disorders
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Tactile and Sensory Interactions
- RNA regulation and disease
- Genetic Neurodegenerative Diseases
- Genetic Associations and Epidemiology
- Hearing, Cochlea, Tinnitus, Genetics
- Neurotransmitter Receptor Influence on Behavior
- Ophthalmology and Visual Impairment Studies
- Neurological diseases and metabolism
- Amyotrophic Lateral Sclerosis Research
- Neuroscience of respiration and sleep
- Ginkgo biloba and Cashew Applications
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Microtubule and mitosis dynamics
- Glaucoma and retinal disorders
- Advanced MRI Techniques and Applications
- Genomic variations and chromosomal abnormalities
Mayo Clinic in Florida
2017-2024
Ludwig-Maximilians-Universität München
2006-2024
Centre de recherche en Epidémiologie et Santé des Populations
2022-2024
Université de Versailles Saint-Quentin-en-Yvelines
2022-2024
Université Paris-Saclay
2022-2024
Max Planck Institute of Psychiatry
2012-2024
Inserm
2022-2024
Center for Human Genetics
2024
Jacksonville College
2017-2022
Hertie Institute for Clinical Brain Research
2022
Neurostimulation of the subthalamic nucleus reduces levodopa-related motor complications in advanced Parkinson's disease. We compared this treatment plus medication with medical management.In randomized-pairs trial, we enrolled 156 patients disease and severe symptoms. The primary end points were changes from baseline to six months quality life, as assessed by Disease Questionnaire (PDQ-39), severity symptoms without medication, according Unified Rating Scale, part III (UPDRS-III).Pairwise...
Abstract The patterns of regional cerebral blood flow (rCBF) increases and decreases in PET were compared for unimodal vestibular, visual, simultaneous vestibular visual stimulation. Thirteen healthy volunteers exposed to a) caloric stimulation, b) small‐field motion stimulation roll, c) pattern Unimodal led activations cortex areas, particular the parieto‐insular (PIVC), concurrent deactivations cortical areas [Brodmann area (BA) 17–19]. striate motion‐sensitive middle temporal/middle...
Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson's disease (PD). The prodromal phase of PD raises the possibility these associations may be explained by reverse causation.To examine using two-sample Mendelian randomisation (MR) and potential for survival incidence-prevalence biases.We used summary statistics from publicly available to estimate association genetic polymorphisms behaviors, Courage-PD (7,369 cases,...
Abstract Background Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association causal or explained by reverse causation confounding. Objective The aim to examine the between genetically predicted and PD using two‐sample Mendelian randomization (MR). Methods We genotyped well‐established instrumental variable located lactase gene (rs4988235) within Courage‐PD consortium (23 studies; 9823...
PET and fMRI studies have revealed that excitation of the vestibular system by caloric or galvanic stimulation not only activates parietoinsular cortex but also bilaterally deactivates occipital visual cortex. Likewise, motion These findings are functionally consistent with hypothesis an inhibitory reciprocal visual-vestibular interaction for spatial orientation perception. Transcallosal visuovisual between two hemispheres was found using half-field stimulation: activation motion-sensitive...
The authors evaluated floccular activity with fMRI during the performance of vertical smooth pursuit eye movements in four patients downbeat nystagmus (DBN) due to cerebellar degeneration and 16 healthy controls. Region interest analysis revealed a significantly diminished activation both lobes downward but not upward DBN. These imaging data support view that functional deficiency flocculi causes
<h3>Objectives:</h3> The objective of this study is to clarify the role (G<sub>4</sub>C<sub>2</sub>)<sub>n</sub> expansions in etiology Parkinson disease (PD) worldwide multicenter Genetic Epidemiology Parkinson9s Disease (GEO-PD) cohort. <h3>Methods:</h3> <i>C9orf72</i> repeats were assessed a GEO-PD cohort 7,494 patients diagnosed with PD and 5,886 neurologically healthy control individuals ascertained Europe, Asia, North America, Australia. <h3>Results:</h3> A pathogenic...
Neurologic disorders in which the etiology and pathogenesis are not yet understood termed idiopathic. Downbeat nystagmus (DBN) is a frequent eye movement disorder that clinically manifests with oscillopsia postural instability. Forty percent of patients DBN classified as having idiopathic DBN, because no underlying pathology can be demonstrated by conventional MRI or laboratory tests.We evaluated gray matter brain volumes 11 compared them to those healthy controls using voxel-based...
Abstract We conducted a PET study to directly compare the differential effects of visual motion stimulation that induced either rollvection about line sight or forward linearvection along this axis in same subjects. The main question was, whether areas respond vection are identical separate and distinct for linearvection. Eleven healthy volunteers were exposed large‐field (100° × 60°) consisting (1) dots accelerating from focus expansion edge screen (forward linearvection) (2) rotating...
The hippocampal formation, including the parahippocampal gyrus, is known to be involved in different aspects of navigation and spatial orientation. Recently, bilateral activation during mental imagery walking running was demonstrated fMRI. For current study question whether distinct functional regions within formation could defined from analysis brain activity stance locomotion healthy, blind, vestibular‐loss subjects. Using same experimental paradigm all groups (fMRI after training actual...
Abstract We report on a woman who had severe sporadic nonprogressive dystonia–parkinsonism syndrome with rapid onset of symptoms at age 21. Secondary causes for dystonia were ruled out. No response to levodopa/carbidopa was seen. The patient fulfilled all diagnostic criteria rapid‐onset dystonia–parkinsonism, except autosomal‐dominant inheritance. Bilateral deep brain stimulation the globus pallidus failed alleviate her symptoms. © 2004 Movement Disorder Society
Patients with unilateral vestibular failure (UVF) experience oscillopsia (apparent motion of the visual scene) during rapid head movements due to increased retinal slip caused by vestibulo-ocular reflex impairment. Oscillopsia is always smaller than net and decreases over time in patients acquired loss; this correlates thresholds for detection tolerance slip. We investigated underlying cortical adaptive processes using stimulation blood oxygen level-dependent (BOLD) fMRI. Optokinetic...
<h3>Objectives:</h3> We aim to clarify the pathogenic role of intermediate size repeat expansions SCA2, SCA3, SCA6, and SCA17 as risk factors for idiopathic Parkinson disease (PD). <h3>Methods:</h3> invited researchers from Genetic Epidemiology Parkinson9s Disease Consortium participate in study. There were 12,346 cases 8,164 controls genotyped, a total 4 repeats within genes. Fixed- random-effects models used estimate summary estimates investigated between-study heterogeneity between...
The role of body mass index (BMI) in Parkinson disease (PD) is unclear. Based on the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment PD (Courage-PD) consortium, we used 2-sample Mendelian randomization (MR) to replicate a previously reported inverse association genetically predicted BMI with investigated whether findings were robust analyses addressing potential survival incidence-prevalence biases. We also examined BMI-PD relation bidirectional by performing reverse MR.