A5083212055- Acute Ischemic Stroke Management
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Health and Medical Studies
- Advanced MRI Techniques and Applications
- Autoimmune Neurological Disorders and Treatments
- Ultrasound Imaging and Elastography
- Stroke Rehabilitation and Recovery
- Genetics and Neurodevelopmental Disorders
- Social and Demographic Issues in Germany
- Sociology and Education Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Neuropathies and Disorders
- Clinical practice guidelines implementation
- Health Literacy and Information Accessibility
- Mental Health and Patient Involvement
- Cardiac Ischemia and Reperfusion
- Glycogen Storage Diseases and Myoclonus
- Venous Thromboembolism Diagnosis and Management
- Interprofessional Education and Collaboration
- Neurological Disorders and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
Asklepios Kliniken Hamburg
2012-2024
Medizinische Hochschule Hannover
2010-2022
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2021
Albertinen Diakoniewerk
2021
University Hospital Heidelberg
2016
Universitätsklinikum Würzburg
2016
Heidelberg University
2003-2016
University of Würzburg
2016
University Hospital Münster
2016
Jena University Hospital
2014
Thematic Section Chairperson 1 Introduction F. Piscaglia – C. Nolsøe 2 Generalities D. Cosgrove 3 Equipment H. P. Weskott 4 Investigator's training O. Gilja 5 Terminology 6 Safety G. ter Haar 7 Paediatric 8 Pancreas M. D'Onofrio 9 Endoscopic CEUS Dietrich 10 Gastrointestinal tract 11 Spleen Catalano 12 Kidney Bertolotto 13 Vesicoureteral reflux 14 Scrotum S. Sidhu 15 Abdominal Trauma 16 Lung and pleural lesions Mathis 17 Vascular Clevert 18 Cerebral vessels Seidel 19 Inflammatory joint...
Key words contrast agent - liver urinary v. ureteric reflux pancreas trauma transcranial US
Anti-IgLON5 disease is a newly defined clinical entity characterized by progressive course with high disability and mortality rate. While precise pathogenetic mechanisms remain unclear, features characteristic of both autoimmune neurodegenerative diseases were reported. Data on immunotherapy are limited, its efficacy remains controversial. In this study, we retrospectively investigated an anti-IgLON5 cohort special focus clinical, serological genetic predictors the response long-term...
Background and Purpose— Sonothrombolysis is a new treatment approach in acute ischemic stroke. The results of monocenter, randomized clinical study are presented. Methods— Subjects with middle cerebral artery main stem occlusion were into target group receiving 1-hour transcranial continuous insonation using 1.8-MHz Doppler ultrasound (US) probe or control group. All underwent standard thrombolysis intravenous recombinant tissue-type plasminogen activator. Results— Thirty-seven subjects...
Transcranial duplex color‐flow sonography provides visualization of intracranial structures, and measures angle‐corrected blood flow velocity in the basal cerebral artenes adults. In 44 patients with central nervous system disease, oblique diameters third middle part lateral ventricle were measured by transcranial using a 2.5‐MHz transducer, compared to computed tomography measurements. The correlation coefficients for ventncle measurements r = 0.83 (p < 0.0001, N 38) 0.73 78),...
<h3>Background and Objectives</h3> CSF in antibody-defined autoimmune encephalitis (AE) subtypes shows subtype-dependent degrees of inflammation ranging from rare often mild to frequent robust. AEs with NMDA receptor antibodies (NMDAR-E) leucine-rich glioma-inactivated protein 1 (LGI1-E) represent opposite ends this spectrum: NMDAR-E typically frequent/robust LGI1-E rare/mild inflammation. For a more in-depth analysis, we characterized findings acute, therapy-naive multicentric,...
Anatomic variety and difficult accessibility of the vertebrobasilar arteries pose considerable problems to conventional ultrasound. We evaluated diagnostic potential transcranial color-coded sonography in distal part this system.We insonated intracranial section through foramen magnum window 24 healthy individuals using a Doppler color flow imaging system connection with 2.5-MHz sector transducer. Magnetic resonance images special inclination planes were performed compared duplex five...
In patients who present with acute ischemic stroke while on treatment non-vitamin K antagonist oral anticoagulants (NOACs), coagulation testing is necessary to confirm the eligibility for thrombolytic therapy. We evaluated current use of in routine clinical practice were NOAC at time stroke.Prospective multicenter observational RASUNOA registry (Registry Acute Stroke Under New Oral Anticoagulants; February 2012-2015). Results locally performed nonspecific (international normalized ratio,...
Background and Purpose— Prospective data on the safety of endovascular thrombectomy in acute stroke patients non–vitamin K antagonist oral anticoagulants are lacking. Methods— multicenter observational study. Patients with ischemic undergoing or without preceding thrombolysis were enrolled into Registry Acute Ischemic Stroke Under New Oral Anticoagulants. Baseline characteristics functional outcome at 3 months assessed. Hemorrhagic transformation symptomatic intracranial hemorrhage analyzed....
Transcranial color-coded duplex sonography is a recently introduced method for visualizing (1) the blood flow velocity of basal cerebral arteries and (2) brain parenchyma as an acoustic impedance image. Dislocation third ventricle due to space-occupying stroke important clinical marker. This study evaluated dislocation from midline by transcranial in 10 healthy volunteers. The mean was 0.2 +/- 0.3 mm. Eighteen patients were investigated within 12 hours both computed tomography (CT) measured....
Background and Purpose —Color-coded perfusion maps can be calculated from ultrasound harmonic gray-scale imaging data to analyze brain tissue perfusion. Methods —In 13 healthy volunteers, 2 doses (0.5 1.5 mL) of Optison, a perfluoropropane-containing contrast agent, were injected intravenously, they produced strong increase in echo enhancement the parenchyma. The agent was twice for examination both hemispheres. A total 24 hemispheres per dose available further analysis. We used...
Factors influencing access to stroke unit (SU) care and data on quality of SU in Germany are scarce. We investigated characteristics patients directly admitted a as well patient-related structural factors adherence predefined indicators acute across hospitals providing care. Data were derived from the German Stroke Registers Study Group (ADSR), voluntary network 9 regional registers for monitoring Germany. Multivariable logistic regression analyses performed investigate direct admission SU....
Background and Purpose —A number of controlled trials have evaluated the benefit intravenous thrombolysis in acute stroke with inconsistent results. None these studies assessed initial vascular status or provided information regarding recanalization rate after therapy. Further need to clarify whether certain subgroups might possibly more than others from thrombolysis. Therefore, a fast valid method for assessment cerebrovascular is needed. In this multicenter study, we potentials limitations...
Stroke patients should be cared for in accordance with evidence-based guidelines. The extent of implementation guidelines the acute care stroke Germany has been unclear to date.The regional quality assurance projects that cooperate framework German Registers Study Group (Arbeitsgemeinschaft Deutscher Schlaganfall-Register, ADSR) collected data on 627 hospitals 2012. hospital or transient ischemic attack (TIA) was assessed basis 15 standardized, indicators and compared across nine...
Harmonic imaging increases the signal‐to‐noise ratio in greyscale imaging. With use of ultrasound contrast agents (UCA), brain perfusion seems possible. The authors used an system connection with a 1.8/3.6‐MHz harmonic sector transducer and acoustic densitometry unit for quantification intensity thalamus (THAL), temporoparietal white matter (TPWM), lateral fissure (LF). Ten milliliters BY963, spherosome‐air‐based UCA, was injected intravenously 12 healthy volunteers. Timeintensity curves...
ABSTRACT Stroke is one of the major causes death and disabilities in industrialized countries. Ultrasound imaging a largely wide spread bedside technique that easily accessible valuable case emergency but suffers from fact ultrasound wave has to cross skull for brain imaging. However, contrast agents new contrast‐specific modalities have helped improve diagnostic quality transcranial ultrasonography. This review article surveys discusses current state microbubbles technology use...
To investigate the genetic determinants of most common type antibody-mediated autoimmune encephalitis, anti-NMDA receptor (anti-NMDAR) encephalitis.We performed a genome-wide association study in 178 patients with anti-NMDAR encephalitis and 590 healthy controls, followed by colocalization analysis to identify putatively causal genes.We identified 2 independent risk loci harboring significant variants (p < 5 × 10-8, OR ≥ 2.2), 1 on chromosome 15, only LRRK1 gene, 11 centered ACP2 NR1H3 genes...