A5015676669- American History and Culture
- Motor Control and Adaptation
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- American Environmental and Regional History
- Functional Brain Connectivity Studies
- American Constitutional Law and Politics
- Hemispheric Asymmetry in Neuroscience
- Archaeology and Natural History
- Neural and Behavioral Psychology Studies
- Microfinance and Financial Inclusion
- Cardiac, Anesthesia and Surgical Outcomes
- Frailty in Older Adults
- Financial Literacy, Pension, Retirement Analysis
- Multiple Sclerosis Research Studies
- Vestibular and auditory disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Canadian Identity and History
- Nerve Injury and Rehabilitation
- Libraries and Information Services
- Psychiatric care and mental health services
- Colonialism, slavery, and trade
- Cholinesterase and Neurodegenerative Diseases
Milwaukee School of Engineering
2007-2023
University Medical Center of the Johannes Gutenberg University Mainz
2015-2021
Johannes Gutenberg University Mainz
2003-2021
Ruhr Museum
2021
Kardiologie Frankfurt-Sachsenhausen
2020
Krankenhaus Sachsenhausen
2017-2019
St. Boniface Hospital
2017-2018
University of Manitoba
2014-2018
University of Auckland
2017
Goethe University Frankfurt
2005-2012
The corpus callosum (CC) is the principal white matter fiber bundle connecting neocortical areas of two hemispheres. Although an object extensive research, important details about anatomical and functional organization human CC are still largely unknown. Here we focused on callosal motor fibers (CMFs) that connect primary cortices (M1) Topography somatotopy CMFs were explored by using a combined magnetic resonance imaging/diffusion tensor imaging fiber-tracking procedure. CMF microstructure...
Motor learning is important throughout life for acquisition and adjustment of motor skill. The extent may be modulated by the history cortex activity, but little known which metaplasticity rule (homeostatic vs nonhomeostatic) governs this interaction. Here, we explored in nine healthy adults effects three different paired associative stimulation (PAS) protocols on subsequent rapid thumb flexion movements. PAS resulted either a long-term potentiation (LTP)-like increase excitability...
Motor inhibitory control implemented as response inhibition is an essential cognitive function required to dynamically adapt rapidly changing environments. Despite over a decade of research on the neural mechanisms inhibition, it remains unclear, how exactly initiated and implemented. Using multimodal MEG/fMRI approach in 59 subjects, our results reliably reveal that by right inferior frontal gyrus (rIFG) form attention-independent top-down involves modulation beta-band activity....
In 37 patients with early relapsing–remitting multiple sclerosis (RRMS), a multimodal EP score (mEPS) and clinical scores (Expanded Disability Status Scale (EDSS) functional composite (MSFC)) were obtained prospectively over 24 months. Changes in mEPS correlated changes EDSS (Spearman’s ρ = 0.69, p < 0.0001) MSFC (ρ –0.41, 0.02). Patients relevant progression ( n 7) showed stronger deterioration than clinically stable (10.8 ± 3.2 versus 1.3 0.8, 0.005). Baseline was not significantly...
Due to the high prevalence of depressive disorders, it is mandatory develop therapeutic strategies that provide universal access and require limited financial human resources. Web-based approaches fulfill these conditions.The objective our study was assess feasibility, acceptability, efficacy a supervised, individualized 8-week exercise intervention conducted for patients with moderate severe depression.We recruited 20 unipolar depression randomly assigned them into 2 groups (intervention,...
In relapsing-remitting multiple sclerosis (RRMS) the corpus callosum (CC) is often and early affected by macroscopic lesions when investigated conventional MRI. We sought to determine which extent microstructural effective disconnection of CC are already present in RRMS patients at earliest stages disease prior evidence lesion. compared 16 very (median expanded disability status scale (EDSS), 1.5; range, 0-2.0) an age-matched group healthy controls focused analysis motor CC, i.e. that part...
Abstract The ipsilateral silent period (iSP) is thought to depend on activity transmitted by the corpus callosum but corticospinal pathways may also contribute. Because presence of differs between small hand muscles, we compared iSP in first dorsal interosseous (FDI) and abductor pollicis brevis (APB) muscles. was elicited 20 healthy subjects focal transcranial magnetic stimulation one primary motor cortex during maximal voluntary contraction target muscle. duration significantly longer FDI...
In stimulus-selective stop-signal tasks, the salient stop signal needs attentional processing before genuine response inhibition is completed. Differential prefrontal involvement in capture and has been linked to right inferior frontal junction (IFJ) ventrolateral cortex (VLPFC), respectively. Recently, it suggested that stopping may be accomplished by following different strategies: individuals selectively inhibit their only upon detecting a (independent discriminate then strategy) or...
Little is known about the spatiotemporal dynamics of cortical responses that integrate slightly asynchronous somatosensory inputs from both hands. This study aimed to clarify timing and magnitude interhemispheric interactions during early integration bimanual information in different regions their relevance for object manipulation exploration. Using multi-fiber probabilistic diffusion tractography MEG source analysis conditioning-test (C-T) median nerve evoked fields healthy human subjects,...
While previous investigations have demonstrated the benefit of cardiac rehabilitation (CR) on outcomes after surgery, association between pre-operative frailty and post-operative CR completion is unclear. The purpose this retrospective cohort study was to determine if scores impacted post-operatively influenced in 114 surgery patients. Frailty assessed with use Clinical Scale (CFS), Modified Fried Criteria (MFC), Short Physical Performance Battery (SPPB), Functional Index (FFI). A...
In the primary and secondary prevention of civilization diseases, regular physical activity is recommended in international guidelines to improve disease-related symptoms, delay progression disease, or enhance postoperative outcomes. preoperative context, there has been a paradigm shift favor using preconditioning concepts before surgery. Web-based interventions seem an innovative effective tool for delivering general information, individualized exercise recommendations, peer support.Our...
Unexpected and thus surprising events are omnipresent oftentimes require adaptive behavior such as unexpected inhibition or action. The current theory of suggests that just like global stopping recruit a fronto-basal-ganglia network. A suppressive effect impacting ongoing motor responses cognition is specifically attributed to the subthalamic nucleus (STN). Previous studies either used separate tasks presented unexpected, task-unrelated stimuli during response relate neural signature...
In this combined electroencephalographic and magnetic resonance imaging (MRI) study, the asymmetry of functional structural measures in human parietal operculum (PO) were investigated. Median nerve somatosensory evoked potential recordings showed maximum scalp potentials over contralateral (N80, N110) ipsilateral (N100, N130) temporal electrode positions. accordance, MRI-coregistered source analysis revealed two electrical sources PO. The dipole orientations contra- with earlier peak...
Paired associative transcranial magnetic stimulation (PAS) has been shown to induce long-term potentiation (LTP)-like or depression (LTD)-like change in excitability of human primary motor cortex (M1), as probed by evoked potential (MEP) amplitude. In contrast, little is known about PAS effects on volitional cortical activity. 10 healthy subjects, movement related potentials (MRCP) were recorded index activity during preparation simple thumb abduction (prime mover: abductor pollicis brevis,...