A5045043707- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Visual perception and processing mechanisms
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Bipolar Disorder and Treatment
- Advanced Image Processing Techniques
- Neuroscience and Neural Engineering
- Medical Imaging Techniques and Applications
- Color Science and Applications
- Neurological disorders and treatments
- Image Enhancement Techniques
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
Leibniz Institute for Resilience Research
2020-2024
Goethe University Frankfurt
2014-2024
University Hospital Frankfurt
2018-2019
Hypofunctioning of the N-methyl-D-aspartate receptor (NMDA-R) has been prominently implicated in pathophysiology schizophrenia (ScZ). The current study tested effects ketamine, a dissociative anesthetic and NMDA-R antagonist, on resting-state activity recorded with magnetoencephalography (MEG) healthy volunteers. In single-blind cross-over design, each participant (n = 12) received, 2 different sessions, subanesthetic dose S-ketamine (0.006mg/Kg) saline injection. MEG-data were analyzed at...
Motor inhibitory control implemented as response inhibition is an essential cognitive function required to dynamically adapt rapidly changing environments. Despite over a decade of research on the neural mechanisms inhibition, it remains unclear, how exactly initiated and implemented. Using multimodal MEG/fMRI approach in 59 subjects, our results reliably reveal that by right inferior frontal gyrus (rIFG) form attention-independent top-down involves modulation beta-band activity....
Autism spectrum disorder (ASD) is a common developmental characterized by communication difficulties and impaired social interaction. Recent results suggest altered brain dynamics as potential cause of symptoms in ASD. Here, we aim to describe information-processing consequences these alterations measuring active information storage (AIS) – key quantity the theory distributed computation biological networks. AIS defined mutual between semi-infinite past process its next state. It measures...
Unexpected and thus surprising events are omnipresent oftentimes require adaptive behavior such as unexpected inhibition or action. The current theory of suggests that just like global stopping recruit a fronto-basal-ganglia network. A suppressive effect impacting ongoing motor responses cognition is specifically attributed to the subthalamic nucleus (STN). Previous studies either used separate tasks presented unexpected, task-unrelated stimuli during response relate neural signature...
People with schizophrenia (PSZ) are impaired in attentional prioritization of non-salient but relevant stimuli over salient distractors during visual working memory (VWM) encoding. Conversely, guidance top-down attention by external predictive cues is intact. Yet, it unknown whether this preserved ability can help PSZ encode more information the presence distractors.
Summary Both the right inferior frontal gyrus (rIFG) and pre-supplementary motor area (pre-SMA) are crucial for successful response inhibition. However, particular functional roles of those two regions have been controversially debated more than a decade now. It is unclear whether rIFG directly initiates stopping or serves an attentional function, whereas triggered by pre-SMA. The current multimodal MEG/fMRI study sought to clarify role temporal activation order both in inhibition using...
Abstract Studying the visual system with fMRI often requires using localizer paradigms to define regions of interest (ROIs). However, considerable interindividual variability cerebral cortex represents a crucial confound for group-level analyses. Cortex-based alignment (CBA) techniques reliably reduce macroanatomical variability. Yet, their utility has not been assessed field paradigms, which map specific parts within retinotopically organized areas. We evaluated CBA an attention-enhanced...
ABSTRACT BACKGROUND Persistent deficits in working memory (WM) and attention have considerable clinical functional impact people with bipolar disorder (PBD). Understanding the neurocognitive underpinnings of these interacting cognitive constructs might facilitate discovery more effective pro-cognitive interventions. Therefore, we employed a paradigm designed for jointly studying attentional control WM encoding. METHODS We used visuospatial change-detection task using four Gabor Patches...
Abstract Recently, there has been a resurgence in experimental and conceptual efforts to understand how brain rhythms can serve organize visual information. Oscillations provide temporal structure for neuronal processing form basis integrating information across areas. Here, we use bistable paradigm data‐driven approach test the hypothesis that oscillatory modulations associate with integration or segregation of elements. Spectral signatures perception bound unbound configurations moving...
Cognitive impairments including deficits in working memory are commonly observed schizophrenia. A bottom-up attentional bias has been suggested for encoding visually salient yet irrelevant information. To date it is not known if this persists when additional top-down information the form of a predictive cue provided. We were motivated to clarify issue. 40 patients with schizophrenia measured and matched healthy control participants. During change detection task four Gabor patches (two...
Patients with schizophrenia suffer from profound impairments of working memory and selective attention. These cognitive domains show a considerable overlap on both the behavioral neurophysiological level. Importantly, attention appears to be crucial for selection information encoded into memory. A number studies have demonstrated that efficiency this “gatekeeper” function influences performance. Furthermore, behavioural evidence indicates, patients specific deficit when required suppress...
ABSTRACT Studying the visual system with fMRI often requires using localizer paradigms to define regions of interest (ROIs). However, considerable interindividual variability cerebral cortex represents a crucial confound for group-level analyses. Cortex-based alignment (CBA) techniques reliably reduce macroanatomical variability. Yet, their utility has not been assessed field paradigms, which map specific parts within retinotopically organized areas. We evaluated CBA an attention-enhanced...
ABSTRACT Background People with schizophrenia (PSZ) are impaired in attentional prioritization of non-salient but relevant stimuli over salient distractors during visual working memory (VWM) encoding. Conversely, guidance top-down attention by external predictive cues is intact. Yet, it unknown whether this preserved ability can help PSZ encode more information the presence distractors. Methods We employed a visuospatial change-detection task using four Gabor patches differing orientations...