A5012549560- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Neuroscience and Neuropharmacology Research
- T-cell and B-cell Immunology
- Immune cells in cancer
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- Vector-borne infectious diseases
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Functional Brain Connectivity Studies
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Nicotinic Acetylcholine Receptors Study
- Inflammasome and immune disorders
- Toxoplasma gondii Research Studies
- Social and Demographic Issues in Germany
- Sociology and Education Studies
- Nuclear Receptors and Signaling
- Viral Infections and Vectors
- Obesity and Health Practices
- Nerve injury and regeneration
- Research on Leishmaniasis Studies
- Melanoma and MAPK Pathways
University of Freiburg
2008-2021
Institute of Medical Microbiology and Hygiene
2021
University Medical Center of the Johannes Gutenberg University Mainz
2014-2020
Johannes Gutenberg University Mainz
2014-2020
ETH Zurich
2016
Max Planck Institute for Brain Research
2014-2015
Ernst Strüngmann Institute for Neuroscience
2014-2015
Hypertension Institute
2014
University of Cologne
2012
Hypofunctioning of the N-methyl-D-aspartate receptor (NMDA-R) has been prominently implicated in pathophysiology schizophrenia (ScZ). The current study tested effects ketamine, a dissociative anesthetic and NMDA-R antagonist, on resting-state activity recorded with magnetoencephalography (MEG) healthy volunteers. In single-blind cross-over design, each participant (n = 12) received, 2 different sessions, subanesthetic dose S-ketamine (0.006mg/Kg) saline injection. MEG-data were analyzed at...
NOD2, the nucleotide-binding domain and leucine-rich repeat containing gene family (NLR) member 2 is involved in mediating antimicrobial responses. Dysfunctional NOD2 activity can lead to severe inflammatory disorders, but regulation of still poorly understood. Recently, proteins tripartite motif (TRIM) protein have emerged as regulators innate immune responses by acting E3 ubiquitin ligases. We identified TRIM27 a new specific binding partner for NOD2. show that physically interacts with...
Ongoing axonal degeneration is thought to underlie disability in chronic neuroinflammation, such as multiple sclerosis (MS), especially during its progressive phase. Upon inflammatory attack, axons undergo pathological swelling, which can be reversible. Because we had evidence for beneficial effects of T helper 2 lymphocytes experimental neurotrauma and discovered interleukin-4 receptor (IL-4R) expressed on MS lesions, aimed at unraveling the IL-4 neuroinflammatory axon injury. We...
Schizophrenia is characterized by dysfunctions in neural circuits that can be investigated with electrophysiological methods, such as EEG and MEG. In the present human study, we examined event-related fields (ERFs), a sample of medication-naive, first-episode schizophrenia (FE-ScZ) patients ( n = 14) healthy control participants 17) during perception Mooney faces to investigate integrity neuromagnetic responses their experience-dependent modification. ERF were analyzed for M100, M170, M250...
Although the impact of Th17 cells on autoimmunity is undisputable, their pathogenic effector mechanism still enigmatic. We discovered soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) complex proteins in that enable a vesicular glutamate release pathway induces local intracytoplasmic calcium and subsequent damage neurons. This glutamine dependent triggered by binding β1-integrin to vascular cell adhesion molecule 1 (VCAM-1) neurons inflammatory context. Glutamate...
Significance Multiple sclerosis (MS) is the most common chronic inflammatory disease of central nervous system in western world and leads to devastating disability young adults, with only limited treatment options currently available. Our recent work demonstrates that pharmacological inhibition protein kinase CK2 (CK2) results encephalitogenic human mouse T helper 17 (T H 17) cell development effector function while at same time promoting induced regulatory (iT reg ) cells. Hence, modulation...
Abstract Activin has emerged as an important player in different types of cancer, but the underlying mechanisms are largely unknown. We show here that activin overexpression is early event murine and human skin tumorigenesis. This functionally important, since promoted tumorigenesis mice induced by papillomavirus 8 oncogenes. was accompanied depletion epidermal γδ T cells accumulation regulatory cells. Most importantly, increased number macrophages via attraction blood monocytes, which...
To study the role of myeloid cells in central nervous system (CNS) pathogenesis multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), we used intravital microscopy, assessing local cellular interactions vivo EAE animals ex organotypic hippocampal slice cultures. We discovered that actively engulf invading living Th17 lymphocytes, a process mediated by expression activation-dependent lectin T cell–binding partner, N-acetyl-D-glucosamine (GlcNAc)....
Extracellular signal-regulated kinase (ERK) signaling plays a crucial role in regulating immune cell function and has been implicated autoimmune disorders. To date, all commercially available inhibitors of ERK target upstream components, such as mitogen-activated protein (MAP) kinase/ERK (MEKs), but not itself. Here, we directly inhibit nuclear translocation by novel pharmacological approach (Glu-Pro-Glu (EPE) peptide), leading to an increase cytosolic phosphorylation during T helper (Th)17...
Abstract Anaplasma phagocytophilum is a Gram‐negative, obligate intracellular bacterium that exhibits striking tropism for neutrophils. When we depleted mice of neutrophils, found murine susceptibility to anaplasmal infection was dependent on their presence. While serving as sites bacterial replication, neutrophils do not seem act efficient killer cells in A. infection, because deficient antimicrobial effectors such myeloperoxidase, granulocyte elastase, and cathepsin G were fully competent...
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) leading to CNS inflammation and neurodegeneration. Current anti-inflammatory drugs have only limited efficacy on progressive neurodegenerative processes underlining need understand immune-mediated neuronal injury. Cell adhesion molecules play an important role for immune cell migration over blood-brain barrier whereas their in mediating potentially harmful contacts between invading cells neurons...
Beyond the major role of T cells in pathogenesis autoimmune neuroinflammatory disorder multiple sclerosis (MS), recent studies have highlighted impact B on pathogenic inflammatory processes. Follicular helper (Tfh) are essential for promotion cell-driven immune responses. However, their MS and its murine model, experimental encephalomyelitis (EAE), is poorly investigated. A first step to achieving a better understanding contribution Tfh disease consideration cell localization relation...
Anaplasma phagocytophilum is a tick-transmitted obligate intracellular Gram-negative bacterium that replicates in neutrophils. It elicits febrile disease humans and animals. In mouse model, elimination of A. required CD4+ T cells, but was independent IFN-γ other classical antibacterial effector mechanisms. Further, mice deficient for immune recognition signaling via Toll-like receptor (TLR) 2, TLR4 or MyD88 were unimpaired pathogen control. contrast, animals lacking adaptor molecules...
Glia, the helper cells of brain, are essential in maintaining neural resilience across time and varying challenges: By reacting to changes neuronal health glia carefully balance repair or disposal injured neurons. Malfunction these interactions is implicated many neurodegenerative diseases. We present a reductionist model that mimics repair-or-dispose decisions generate hypothesis for cause disease onset. The assumes four tissue states: healthy challenged tissue, primed at risk acute damage...
Introduction: Type II antibody mediated rejection (AMR) represents a challenging problem for kidney allograft survial. Treatment options are scarce and oftentimes without sufficient benefit. Especially which technique of extracorporal elimination HLA-antibodies, i.e. plasmapheresis or immunoadsortions, should be used one is more effective, remains unanswered. This single center retrospective study was conducted to determine clinically relevant different outcome between the two methods....
Die vorliegende Arbeit befasst sich mit der Atiologie, Epidemiologie, den Einflussfaktoren von Adipositas, sowie Edukation und Pravention von ubergewichtigen adiposen Menschen. Der Schwerpunkt wird auf die und Pravention Menschen Ubergewicht Adipositas gelegt, weiteren Verbreitung Einhalt gewahren sollen. Adipositas als eine chronische Gesundheitsstorung verstanden kann durch verschiedene Faktoren, wie beispielsweise positive Energiebilanz, zu wenig Bewegung, genetische psychosoziale...
Abstract Glia, the helper cells of brain, are essential in maintaining neural resilience across time and varying challenges: By reacting to changes neuronal health glia carefully balance repair or disposal injured neurons prevent further tissue damage. Malfunction these interactions is implicated many neurodegenerative diseases. Reductionist models with a minimal number parameters provide opportunity gain insight into biological functions inform experimental designs. We introduce such model...