A5080429196- Nerve injury and regeneration
- Circular RNAs in diseases
- Signaling Pathways in Disease
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Toxin Mechanisms and Immunotoxins
- Neurogenesis and neuroplasticity mechanisms
- Extracellular vesicles in disease
- Spinal Cord Injury Research
- Tryptophan and brain disorders
Johannes Gutenberg University Mainz
2018-2021
University Medical Center of the Johannes Gutenberg University Mainz
2018
Ongoing axonal degeneration is thought to underlie disability in chronic neuroinflammation, such as multiple sclerosis (MS), especially during its progressive phase. Upon inflammatory attack, axons undergo pathological swelling, which can be reversible. Because we had evidence for beneficial effects of T helper 2 lymphocytes experimental neurotrauma and discovered interleukin-4 receptor (IL-4R) expressed on MS lesions, aimed at unraveling the IL-4 neuroinflammatory axon injury. We...
Abstract Axonal mRNA transport and local protein synthesis are crucial for peripheral axon regeneration. To date, it remains unclear how ribosomes localize to axons. They may be co‐transported with mRNAs or, as suggested by recent studies, transferred from Schwann cells (SC). Here, we generated transgenic “RiboTracker” mice expressing tdTomato‐tagged ribosomal L4 in specific cell types when crossed Cre lines. Two neuronal RiboTracker‐Cre lines displayed extremely low levels of axonal...
Abstract Neurons of the central nervous system (CNS) that project long axons into spinal cord have a poor axon regenerative capacity compared to neurons peripheral system. The corticospinal tract (CST) is particularly notorious for its regeneration. Because this, traumatic injury (SCI) devastating condition remains as yet uncured. Based on our recent observations direct neuronal interleukin-4 (IL-4) signaling leads repair axonal swellings and beneficial effects in neuroinflammation, we...