A5002920852- Tryptophan and brain disorders
- Heart Rate Variability and Autonomic Control
- Stress Responses and Cortisol
- Attention Deficit Hyperactivity Disorder
- Vagus Nerve Stimulation Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Treatment of Major Depression
- Diet and metabolism studies
- Visual perception and processing mechanisms
- EEG and Brain-Computer Interfaces
- Cardiac Health and Mental Health
- Sleep and Work-Related Fatigue
- Memory and Neural Mechanisms
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Diabetes and associated disorders
- Genetics and Neurodevelopmental Disorders
- Gut microbiota and health
- Immune responses and vaccinations
- COVID-19 and Mental Health
- Congenital heart defects research
Goethe University Frankfurt
2020-2025
University Hospital Frankfurt
2021-2024
Semmelweis University
2023
Karolinska Institutet
2023
Vall d'Hebron Hospital Universitari
2023
Oxford University Press (United Kingdom)
2023
Janssen (Switzerland)
2023
Hikma Pharmaceuticals (United Kingdom)
2023
KU Leuven
2016-2022
Universitair Ziekenhuis Leuven
2019
The macrophage theory of depression states that macrophages play an important role in Major Depressive Disorder (MDD).MDD patients (N = 140) and healthy controls 120) participated a cross-sectional study investigating the expression apoptosis/growth lipid/cholesterol pathway genes (BAX, BCL10, EGR1, EGR2, HB-EGF, NR1H3, ABCA1, ABCG1, MVK, CD163, HMOX1) monocytes (macrophage/microglia precursors). Gene expressions were correlated to set previously determined reported inflammation-regulating...
The association between Attention Deficit Hyperactivity Disorder (ADHD) and low-grade inflammation has been explored in children but rarely adults. Inflammation is characteristic of some, not all, patients with ADHD might be influenced by medication also lifestyle factors including nutrition, smoking, stress. It still unclear if any specific symptoms are related to inflammation. Therefore, we assessed 96 inflammatory proteins a deeply phenotyped cohort 126 adult participants stable status...
<title>Abstract</title> Major Depressive Disorder can be conceptualized as a chronic stress condition associated with autonomic dysregulation, including blunted heart rate reactivity, changes in cortisol levels and peripheral inflammation, pointing to sympathetic activation parasympathetic withdrawal. Transcutaneous vagus nerve Stimulation (taVNS) offers non-invasive method stimulate the – key component of system restore balance. Here, we examined whether emotional, cardiac, inflammatory...
Irritability worsens prognosis and increases mortality in individuals with Attention-Deficit Hyperactivity Disorder (ADHD) and/or Borderline Personality (BPD). However, treatment options are still insufficient. The aim of this randomized, double blind, placebo-controlled study was to investigate the superiority a synbiotic over placebo management adults ADHD BPD high levels irritability. conducted between February 2019 October 2020 at three European clinical centers located Hungary, Spain...
Chronic stress and depressive symptoms have both been linked to increased heart rate (HR) reduced HR variability. However, up date, it is not clear whether chronic stress, the mechanisms intrinsic depression or a combination of cause these alterations. Subclinical cases may help answer questions. In healthy working population, we aimed investigate effect on circadian rhythm depends presence differential effects reactivity an acute stressor.1,002 individuals SWEET study completed baseline...
Immune dysregulation has been reported in schizophrenia spectrum disorders (SSD). In the past decade, several trials using anti-inflammatory agents for treatment of SSD have completed, with so far limited success. One such agent used is simvastatin. A recent, large-scale, randomized controlled trial simvastatin augmentation failed to show improvement predefined primary outcome. However, baseline inflammatory profiles were not taken into account. Here we employed a data-driven clustering...
People with schizophrenia (PSZ) are impaired in attentional prioritization of non-salient but relevant stimuli over salient distractors during visual working memory (VWM) encoding. Conversely, guidance top-down attention by external predictive cues is intact. Yet, it unknown whether this preserved ability can help PSZ encode more information the presence distractors.
Abnormalities of heart rate (HR) and its variability are characteristic major depressive disorder (MDD). However, circadian rhythm is rarely taken into account when statistically exploring state or trait markers for depression.
Interleukin 17 (IL-17) is a potent pro-inflammatory cytokine which plays role in autoimmune disorders, such as psoriasis and multiple sclerosis, important for the defense against pathogens, particularly gut. However, IL-17 has recently also gained attention association with suicidal behavior. In this review, we review literature regarding psychiatric disorders suicidality. We take closer look at suicides occurred clinical trial brodalumab, monoclonal antibody targeting receptor. Lastly,...