A5005530798- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- Lipid metabolism and disorders
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Endoplasmic Reticulum Stress and Disease
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Alcohol Consumption and Health Effects
- Pancreatic function and diabetes
- Diet and metabolism studies
- Peroxisome Proliferator-Activated Receptors
- Drug Transport and Resistance Mechanisms
- Phagocytosis and Immune Regulation
- Multiple and Secondary Primary Cancers
- Peptidase Inhibition and Analysis
- Artificial Intelligence in Healthcare
- Appendicitis Diagnosis and Management
- Lipid metabolism and biosynthesis
- Vitamin C and Antioxidants Research
Universitätsklinikum Knappschaftskrankenhaus Bochum
2020-2025
Ruhr University Bochum
2020-2025
University Hospital Magdeburg
2019-2021
Gilead Sciences (United States)
2021
Otto-von-Guericke University Magdeburg
2018-2020
University of Duisburg-Essen
2011-2019
Philipps University of Marburg
2019
Essen University Hospital
2008-2017
Karolinska Institutet
2012
University of Louisville
2012
Abstract Non‐alcoholic fatty liver disease (NAFLD) is the most common in developed countries, and accumulating evidence suggests it as hepatic manifestation of metabolic syndrome (MS). Although published prevalence hepatocellular carcinoma (HCC) low NAFLD/NASH patients, these data have been derived from areas endemic for viral hepatitis. We recruited 162 adults with HCC between February 2007 March 2008, investigated underlying etiologies determined MS related features within each group....
Abstract We have previously shown that Toll-like receptor (TLR)-activated murine nonparenchymal liver cells [(NPC); Kupffer (KC), sinusoidal endothelial (LSEC)] can suppress hepatitis B virus (HBV) replication. Therefore, the aim of this study was to investigate whether HBV has ability counteract TLR-mediated control its Freshly purified hepatocytes and NPCs obtained from C57BL6 mice were stimulated by TLR 1-9 ligands in presence or absence surface antigen (HBsAg), e (HBeAg), virions,...
The prevalence of nonalcoholic steatohepatitis (NASH) associated hepatocellular carcinoma (HCC) is increasing. However, strategies for detection early-stage HCC in patients with NASH have limitations. We assessed the ability GALAD score, which determines risk based on patient sex; age; and serum levels α-fetoprotein (AFP), AFP isoform L3 (AFP-L3), des-gamma-carboxy prothrombin (DCP), to detect NASH.We performed a case-control study 125 (20% within Milan Criteria) 231 without (NASH controls)...
Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common in industrialized countries and may proceed to steatohepatitis (NASH). Apoptosis free acid (FFA)-induced lipotoxicity are important features of NASH pathogenesis. We have shown a hepatoprotective effect adiponectin steatotic livers hepatitis C virus (HCV) patients recent data links bile (BA) metabolism pathogenesis NAFLD. The aim this study was identify potential interactions between BA FFA Liver biopsies serum samples from...
Abstract Acute liver failure (ALF) is associated with massive short-term cell death, whereas chronic injury accompanied by continuous death. Hepatic stellate cells (HSCs) contribute to tissue repair and fibrosis in injury, although their role ALF remains unexplained. Twenty-nine patients (median age = 43 years, 17 females 12 males) according the Liver Failure Study Group criteria were included. Upon diagnosis of after 7 days, we determined stiffness (LS) FibroScan, standard laboratory...
Non-alcoholic fatty liver disease (NAFLD) is closely linked to obesity and constitutes part of the metabolic syndrome, which have been associated with low serum vitamin D (VD). Due known crosstalk between VD transforming growth factor (TGF)-β signalling, has proposed as an antifibrotic treatment.We evaluated association VD, receptor (VDR) fibrosis in primary human hepatic stellate cells (phHSC) 106 morbidly obese patients NAFLD.Treating phHSC ameliorated TGF-β-induced fibrogenesis via both...
Acetaminophen (APAP) overdose remains a frequent cause of acute liver failure, which is generally accompanied by increased levels serum bile acids (BAs). However, the pathophysiological role BAs elusive. Herein, we investigated in APAP-induced hepatotoxicity.We performed intravital imaging to investigate BA transport mice, quantified endogenous concentrations mice and patients with APAP overdose, analyzed tissue mass spectrometry MALDI-mass imaging, assessed integrity blood-bile barrier...
Background & aims: Hepatocyte apoptosis is a key event in non-alcoholic steatohepatitis (NASH). We studied the effect of obesity on free fatty acid (FFA) levels, transport proteins (FATPs) and extrinsic intrinsic activation liver. Methods: Liver biopsies were harvested from 52 morbidly obese patients [body mass index (BMI): 53.82±1.41; age: 45±10.50; 15 males/37 females] undergoing bariatric surgery, scored for NASH, evaluated fibrosis, investigated intrahepatic expression FATPs, death...
Abstract Key features of the metabolic syndrome are insulin resistance and diabetes. The liver as central organ is not only affected by non-alcoholic fatty disease (NAFLD), but may contribute to alterations. We aimed identify potential associations between injury markers diabetes in population-based Heinz Nixdorf RECALL Study. Demographic laboratory data were analyzed participants (n = 4814, age 45 75y). ALT AST values significantly higher males than females. Mean BMI was 27.9 kg/m 2...
Current non-invasive scores for the assessment of severity non-alcoholic fatty liver disease (NAFLD) and identification patients with steatohepatitis (NASH) have insufficient performance to be included in clinical routine. In current study, we developed a novel machine learning approach overcome caveats existing approaches.Non-invasive parameters were selected by an ensemble feature selection (EFS) from retrospectively collected training cohort 164 obese individuals (age: 43.5±10.3y; BMI:...
Summary Background Factors associated with mortality and disease progression in non‐alcoholic fatty liver (NAFLD) steatohepatitis (NASH) are poorly understood. Aims To assess the impact of severity, demographics comorbidities on all‐cause a large, real‐world cohort NAFLD patients. Methods Claims data from German Institut für angewandte Gesundheitsforschung database between 2011 2016 were analyzed retrospectively. Adult patients diagnosed and/or NASH categorised as NAFLD, non‐progressors,...
Despite vaccination programs and direct antiviral treatments, the incidence of virus-related hepatocellular carcinoma (HCC) remains high, while ultrasound-based detection rates for early-stage HCC is continuously low. To address this insufficiency, we set out to characterize whether GALAD score, which incorporates gender, age, serum levels AFP, AFP isoform L3 (AFP-L3), des-gamma-carboxy-prothrombin (DCP), can improve in a Caucasian HBV/HCV cohort. In retrospective German single-center study,...
Introduction Various conditions of liver disease and the downsides biopsy call for a non-invasive option to assess fibrosis. A score would be especially useful identify patients with slow advancing fibrotic processes, as in Non-Alcoholic Fatty Liver Disease (NAFLD), which should undergo histological examination Patients/Methods Classic serum parameters, hyaluronic acid (HA) cell death markers 126 undergoing bariatric surgery morbid obesity were analyzed by machine learning techniques...
Background & Objective Currently, a major clinical challenge is to distinguish between chronic liver disease caused by metabolic syndrome (non-alcoholic fatty disease, NAFLD) from that long term or excessive alcohol consumption (ALD). The etiology of severe affects treatment options and priorities for transplantation organ allocation. Thus we compared physiologically similar NAFLD ALD patients detect biochemical differences improved separation these mechanistically overlapping etiologies....
Pediatric acute liver failure (PALF) is a progressive, potentially fatal clinical syndrome occurring in previously healthy children. Our study aimed to determine the current leading causes of PALF single center Germany, identifying possible prognostic markers. Thirty-seven pediatric patients with were included. Medical records reviewed for demographic, laboratory and data. Laboratory results on admission at peak value, PELD MELD score admission, intensive care support assessed. Fifteen...
Biomarker discovery methods are essential to identify a minimal subset of features (e.g., serum markers in predictive medicine) that relevant develop prediction models with high accuracy. By now, there exist diverse feature selection methods, which either embedded, combined, or independent learning algorithms. Many preceding studies showed the defectiveness single results, cause difficulties for professionals variety fields medical practitioners) analyze and interpret obtained subsets....
Fetuin-A is a pro-inflammatory protein expressed by hepatocytes. Its course in morbidly obese patients with NAFLD (non-alcoholic fatty liver disease) following weight loss BAS (bariatric surgery) has not been fully elucidated yet. In the present study, we prospectively examined effects of on various metabolic factors at 4 weeks and 6 months after surgery. Blood tissues were retrieved from 108 before/during BAS, 50 these individuals met criteria for NASH steatohepatitis). expression was...