A5051882735- Pelvic floor disorders treatments
- Congenital gastrointestinal and neural anomalies
- Gastrointestinal motility and disorders
- Infant Nutrition and Health
- Congenital Diaphragmatic Hernia Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Urinary Bladder and Prostate Research
- Pectus Deformity Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Anorectal Disease Treatments and Outcomes
- Diverticular Disease and Complications
- Congenital Heart Disease Studies
- Gastroesophageal reflux and treatments
- Clinical Nutrition and Gastroenterology
- Intestinal Malrotation and Obstruction Disorders
- Pleural and Pulmonary Diseases
- Congenital Anomalies and Fetal Surgery
- Foreign Body Medical Cases
- Lymphatic Disorders and Treatments
- Occupational and environmental lung diseases
- Cardiovascular Conditions and Treatments
- Intestinal and Peritoneal Adhesions
- Reproductive Health and Technologies
- Intraperitoneal and Appendiceal Malignancies
Universitätsklinikum Erlangen
2014-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2014-2024
Philipps University of Marburg
2023
Comprehensive Cancer Center Erlangen
2014
The efficacy of sacral nerve stimulation (SNS) to treat faecal incontinence has been demonstrated in the short- and mid-term. We analysed SNS outcome first patients with a permanent neurostimulator whom follow-up ranges up 14 years.Of 12 who underwent from 1994 1999, 9 were eligible for long-term analysis (defined as minimum 7 years). In 3 device had be removed because pain or neurological disease. Functional was monitored prospectively by standardized questionnaire. For efficacy, recorded...
Transition of care (TOC; from childhood into adulthood) patients with anorectal malformations (ARM) and Hirschsprung disease (HD) ensures continuation for these patients. The aim this international study was to assess the current status TOC adult (AC) programs ARM HD.A survey developed by members EUPSA, ERN eUROGEN, ERNICA, including patient representatives (ePAGs), comprising four domains: general information, questions about transition adulthood, disease-specific regarding AC programs....
Small blue round cell sarcomas (SBRCSs) are a heterogeneous group of tumors with overlapping morphologic features but markedly varying prognosis. They characterized by distinct chromosomal alterations, particularly rearrangements leading to gene fusions, whose detection currently represents the most reliable diagnostic marker. Ewing (ESs) common SBRCSs, defined fusions involving EWSR1 and transcription factors ETS family, while frequent non-EWSR1-rearranged SBRCSs harbor CIC rearrangement....
Abstract Background In contrast to adults, for whom guidelines on the cholelithiasis treatment exist, there is no consistent of pediatric patients with throughout national and international departments, most probably due lack evidence-based studies. Methods We evaluated German management in a dual approach. Firstly, retrospective, inter-divisional study was established, comparing diagnostics therapy surgery department aged < 25 years visceral our institution over past ten years....
The diagnosis of Hirschsprung's disease is currently based on the identification aganglionosis and presence an increase in acetylcholinesterase-positive hypertrophic nerve fibres large bowel submucosa. However, acetylcholinesterase staining laborious requires a skilled technician. aim this study was to identify method for diagnosing reliably using immunohistochemical panel recently proposed markers.Sixty-nine specimens from 37 patients were evaluated. MAP2 calretinin antibodies shown stain...
<b>Background</b> The literature is silent on the relationship between symptoms and Haller index. Nor there a classification of severity physical complaints. <b>Materials Methods</b> Retrospectively, data from 128 patients (102 funnel, 25 pigeon chest patients, 1 mixed type) were evaluated. To objectify symptoms, we developed score to describe level ailments. This includes 10 different as well situation or frequency in which they occur an impact factor. depends how much affect everyday life....
Background/Aims: Constipation shows both, a high prevalence and significant impact. However, it is often perceived as minor treatment choices are limited. The neuromodulation approach valuable option to be considered. This study assesses the use of non-invasive sacral nerve stimulation reduce constipation in children. Methods: Between February 2013 May 2015, pediatric patients with chronic were treated this procedure, adapted from classical stimulation. A device attached adhesive electrodes...
Background: Diagnosis and management of NEC is based on clinical, radiological laboratory findings. Discrimination pathogens for an improved understanding in preterm infants with congenital heart disease has been previously discussed enables evaluation further biomarkers. Patients Methods: Within a study period 11 years (2008-2019), we identified 107 patients diagnosis at our primary care center. 36 out 54 suffering from high Bell stages who underwent surgery met inclusion criteria. These...
BackgroundEsophageal atresia (EA) with or without tracheoesophageal fistula (TEF) remains one of the most common gastrointestinal neonatal malformations. Even though postoperative management is standardized, it differs between hospitals and disease-associated clinical factors that may play a role in outcome have not yet been assessed detail.MethodsIn this monocentric retrospective study, data 43 patients EA 2010 2018 were analyzed. Analysis includes assessment background, surgical technique,...
Perforation of esophagus or stomach is a potential complication during and after insertion gastric tube in neonates. The aim this study was to analyze different types tubes three-dimensional (3D) model neonatal regarding perforations.
A therapeutic effect of sacral neuromodulation (SNM) on fecal incontinence (FI) and quality life has been proven in adults. SNM is, however, rarely used pediatric cases. The aim the study is to investigate effects constipation a prospective parallel-group trial.
Abstract Background Even if understanding of neuronal enteropathies, such as Hirschsprung's disease and functional constipation, has been improved, specialized therapies are still missing. Sacral neuromodulation (SNM) established in the treatment defecation disorders adults. The aim study was to investigate effects SNM children adolescents with refractory symptoms chronic constipation. Methods A two‐centered, prospective trial conducted between 2019 2022. applied continuously at individually...
In adult patients with chronic refractory constipation, invasive sacral neuromodulation (SNM) has been applied successfully. There is a need for less solutions while providing comparable therapeutic effects in children and adolescents. We present prospective, interventional case-control study on the application of noninvasive SNM.Patients constipation to conservative treatment were prospectively included from 2018 2021 randomized either SNM (SNM group: single current stimulation 24 h/d,...
Malignant peritoneal mesothelioma is extremely rarely seen in young patients. A 16 year-old girl presented with appendicitis-like acute abdominal pain. Intra-operatively, multiple confluent nodules were on the entire greater omentum and pelvis infiltrating uterus both ovaries. Biopsies obtained interpreted as serous ovarian carcinoma. Radical surgical resection hyperthermic intraperitoneal chemotherapy (HIPEC) carboplatin was performed followed by 2 cycles of carboplatin/paclitaxel....
Botulinum toxin injections in the anal sphincter apparatus (Botox) and enteral neuromodulation (ENM) are options for treatment of refractory chronic constipation. We present a retrospective comparative observational study.From 2014 to 2022, pediatric patients with constipation were either treated Botox or ENM continuation conservative treatment. Comparison was conducted regarding primary outcome variables defecation frequency, stool consistency, abdominal pain. Secondary outcomes fecal...
Necrotizing enterocolitis (NEC) continues to cause high morbidity and mortality. Identifying early predictors for severe NEC is essential improve therapy optimize timing surgical intervention. We present a retrospective study of patients with NEC, treated between 2010 2020, trying identify factors influencing the severity NEC. Within period, 88 affected infants or NEC-like symptoms are analyzed. A multiple logistic regression analysis reveals following three independent in Bell stage III:...
Background As the population ages, low-energy thoracic injuries are becoming increasingly relevant in individual injuries, particularly pulmonary contusions (PCs) and their common concomitant injuries. The objective of this study was to determine prevalence age distribution trauma, especially PC, make conclusions about secondary diagnoses developments management. Methods A retrospective analysis 209,820 cases, based on German routine data from years 2009 2015, with a main diagnosis (MD) or...
Background: Traditionally open procedures have been replaced by minimally invasive techniques in the correction of pectus excavatum. Efforts to improve extent mobilization chest wall and its stabilization led constant modifications. There is currently no consensus about best procedure for Methods: Based on contributions a single institution last 60 years, we present various strategies used excavatum evolution operational procedures. These approaches are compared with those performed...
The current concept of recruiting residual function an inadequate pelvic organ by electrostimulation involves stimulation the sacral spinal nerves at level canal. rationale for applying SNS to fecal incontinence was based on clinical observations its effect bowel habits and anorectal continence in urologic patients (increased angulation anal canal closure pressure) anatomic considerations: dissection demonstrated a dual peripheral nerve supply striated floor muscles that govern these...
Introduction . Asymmetric omphalopagus is a rare situation of conjoined twinning, in which grossly defective twin attached to the thorax and upper abdomen main twin. We describe case an asymmetric accompanied by normal triplet after assisted reproductive technology (ART) tried further characterize all aspects twins. Case Presentation : Perioperative diagnostic imaging was carried out followed autopsy evaluate parasite histological, immunohistochemical, molecular biological evaluation. The...
Hintergrund: Eingriffe an der vorderen Brustwand können zu Wundheilungsstörungen führen. Untersucht wird, ob die Anwendung einer präventiven Unterdrucktherapie das Risiko Wundheilungsstörung nach offener Brustwandkorrektur reduzieren kann. Methodik: In retrospektiven Vergleichsanalyse von 100 Patienten mit Korrektur Trichter- oder Kielbrustdeformität in den Jahren 2010 bis 2012 wurden 50 aufeinanderfolgend behandelte Patienten, deren Wunde 5 Tage postoperativ mittels Prevena™ (KCI...
Complex and mature funnel chest deformities are traditionally managed with open surgical procedures. Elastic stable repair (ESCR) has been used successfully safely for relapse corrections. Does pure plate osteosynthesis in ESCR allow comparable corrective potency implant safety as hybrid methods metal bars?Data from 86 patients correction between 2011 2015 were analyzed this retrospective study. Exclusion criteria included being under 12 years of age, having a history septic wound healing...
Deleted in malignant brain tumors 1 (DMBT1) is involved innate immunity and epithelial differentiation. It has been proven to play a role various states of inflammation or hypoxia fetal gastrointestinal pulmonary diseases. Discrimination pathogenesis necrotizing enterocolitis (NEC) based on cardiac status improves the understanding NEC different patient subgroups. We aimed at examining DMBT1 expressions regarding their association with leading impaired intestinal perfusion, intraoperative...
Abstract Background A therapeutic effect of sacral neuromodulation (SNM) on fecal incontinence (FI) and quality life has been proven in adults. SNM is, however, rarely used pediatric cases. The aim the study is to investigate effects constipation a prospective parallel-group trial. Methods monocentric, randomized, unblinded, trial conducted. conducted invasive variant an innovative, external approach with adhesive electrodes (enteral neuromodulation, ENM). We include patients according ROME...