A5022826683- Parvovirus B19 Infection Studies
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Dermatological and COVID-19 studies
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- Respiratory viral infections research
- Viral Infections and Immunology Research
- Blood groups and transfusion
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Hepatitis C virus research
- Poxvirus research and outbreaks
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Tracheal and airway disorders
- Prenatal Screening and Diagnostics
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Immunodeficiency and Autoimmune Disorders
- Influenza Virus Research Studies
- Medical and Health Sciences Research
- Animal Virus Infections Studies
University Hospital Bonn
1999-2024
University of Bonn
2010-2021
German Center for Infection Research
2018-2021
Faculty (United Kingdom)
2020
Institute of Virology of the Slovak Academy of Sciences
2020
Institut für Hygiene und Umwelt
2011
Katholisches Kinderkrankenhaus Wilhelmstift
2011
Essen University Hospital
2006
GTx (United States)
2006
University Hospital Frankfurt
1996-1999
Members of the family Parvoviridae are small, resilient, non-enveloped viruses with linear, single-stranded DNA genomes 4-6 kb. Viruses in two subfamilies, Parvovirinae and Densovirinae, distinguished primarily by their respective ability to infect vertebrates (including humans) versus invertebrates. Being genetically limited, most parvoviruses require actively dividing host cells and/or tissue specific. Some cause diseases, which range from subclinical lethal. A few co-infection helper...
Abstract The world faces an unprecedented SARS-CoV2 pandemic where many critical factors still remain unknown. case fatality rates (CFR) reported in the context of SARS-CoV-2 substantially differ between countries. For infection with its broad clinical spectrum from asymptomatic to severe disease courses, rate (IFR) is more reliable parameter predict consequences pandemic. Here we combined virus RT-PCR testing and assessment for antibodies determine total number individuals infections a...
Since early November 2016, the number of laboratory-confirmed norovirus infections reported in Germany has been increasing steeply. Here, we report detection and genetic characterisation an emerging recombinant, GII.P16-GII.2. This strain was frequently identified as cause sporadic cases well outbreaks nine federal states Germany. Our findings suggest that emergence GII.P16-GII.2 contributed to rising case numbers gastroenteritis
Summary We report about the infection of an 18‐year‐old man with orthopox virus (OPV) which was transmitted by a cat. The infectious route from cat to could be proved epidemiological, virological and serological methods. corresponding techniques are described. patient had not been vaccinated against smallpox intensively immunosuppressed medication on account severe endogeneous eczema combined allergic asthma bronchiale. A cyclic poxvirus disease developed generalised, partly confluent pox...
Enterovirus D68 (EV-D68) was detected in 93 patients from five European countries between 1 January 2019 and 15 2020, a season with expected low circulation. Patients were primarily children (n = 67, median age: 4 years), 59 required hospitalisation had severe neurologic manifestations. Phylogenetic analysis revealed two clusters the B3 subclade A2/D. This circulation of EV-D68 associated neurological manifestations stresses importance surveillance diagnostics beyond peak years.
Abstract Objectives The aim of our study was to determine the outcome pregnancies after intrauterine management fetal parvovirus B 19 infection. Design Retrospective study. Subjects A total 37 cases maternofetal infection, 35 which were associated with hydrops fetalis, referred tertiary level center between 1989 and 1996. With regard hydrops, no apparent cause other than infection found in any patient. Methods In all patients, cordocentesis performed assess degree anemia. When anemia...
Objective To assess long term neurodevelopmental outcome of children after intrauterine intravascular red cell transfusion (IUT) for Parvovirus B19‐induced fetal hydrops. Design Data study were investigated retrospectively. Neurodevelopmental evaluation was performed by appropriate standard tests (Griffiths, Snijders–Oomen, Kaufmann Assessment Battery Children tests). Setting Tertiary care university teaching hospital. Sample Twenty who had Parvovirus‐induced hydrops and packed blood cells...
Due to their high resistance inactivation procedures, nonenveloped viruses such as parvovirus B19, human bocavirus (HBoV), 4 (PARV4), hepatitis A (HAV) and E virus (HEV) pose a particular threat blood products. Virus transmission patients treated with products presents an additional burden disease. We determined the frequency amount of nucleic acid specific for in recently manufactured preparations commercial coagulation factor concentrates.At least three different batches each 13...
Abstract Background Lower respiratory tract infections are among the main causes of death. Although there many viruses, diagnostic efforts focused mainly on influenza. The Respiratory Viruses Network (RespVir) collects infection data, primarily from German university hospitals, for a high diversity by pathogens. In this study, we computationally analysed subset RespVir database, covering 217,150 samples tested 17 different viral pathogens in time span 2010 to 2019. Methods We calculated...
Using HIV sequence data to characterize clusters of transmission may provide insight into the epidemic. Phylogenetic and network analyses were performed infer putative relationships between HIV-1 partial pol sequences from 2,774 individuals receiving care in three German regions 1999-2016. The have common that they host some largest annual festivals Europe (Carnival Oktoberfest). Putative links with (n = 150,396) Los Alamos Sequence database evaluated. A total 595/2,774 (21.4%) linked at...
SARS-CoV-2 infection has been characterized as an upper and lower respiratory tract with symptoms ranging from sore throat, cough, headache, fatigue to a severe syndrome that requires intensive care [1-7]. Although death rate recorded for in comparison other recent coronavirus outbreaks, such MERS or SARS, compromised status on admission associated fatal outcomes. Among the >1200 SARS-CoV-2-infected individuals Germany date, many of diagnosed persons show mild no clinical signs infection....
Summary It is known that parvovirus B19 (B19) transmitted to hemophiliacs by clotting factors prepared from human plasma. However, it not clear whether also the more recently used inactivated factor preparations. Therefore, we investigated 69 hemophiliacs, mostly children, receiving only virus-inactivated factors. 49 of them (71%) were IgG-positive and 18 (37%) IgM-positive. In contrast, out 73 age-matched controls 10 (14%) IgG-positive, two being treated before 1984 with noninactivated...
Abstract In this short report we discuss the temporal association between an acute life threatening event (ALTE) and a RT‐PCR confirmed coronavirus HCoV‐229E infection in 4 months old otherwise healthy infant. More detailed microbiological investigations of affected children even without apparent signs respiratory tract may help to clarify etiology some patients extend our understanding pathogenesis. PCR‐based techniques should be utilized increase sensitivity detection for new viral...
Abstract Following a publication on the sudden outbreak of hepatitis A (HAV) infections in Italian hemophiliacs after treatment with solvent detergent (S/D) virus‐inactivated factor VIII concentrate, we retrospectively examined our patients for HAV seroconversions and clinical symptoms an acute infection at center. We found that between 1988 1992, 17 hemophilia displayed IgG seroconversions. Of these patients, 13 also had IgM seroconversion 10 exhibited infection. feature common to all was...
In 2018, a cluster of pediatric human parechovirus (HPeV) infections in 2 neighboring German hospitals was detected. Viral protein 1 sequence analysis demonstrated co-circulation different HPeV-3 sublineages and HPeV-1 -5 strains, thereby excluding nosocomial outbreak. Our findings underline the need for HPeV diagnostics outbreak investigations.
In August 1990 an orthopox virus (OPV) had been isolated from a severe case of generalized infection with lethal outcome in immunosup-pressed 18-year-old man. this communication we present detailed characterization the causative strain. Based on distinct epitope configurations detected by various monoclonal antibodies isolate could be differentiated other OPV species and was classified as cowpox (CP). This classification confirmed species-specific PCR assay establishing physical maps for...
Abstract Cardioviruses cause myocarditis and encephalomyelitis in rodents; human cardioviruses have not been ascribed to any disease. We screened 6,854 cerebrospinal fluid 10 myocardium specimens from children adults. A genotype 2 cardiovirus was detected a child who died of sudden infant death syndrome, untypeable were with meningitis.
Herpes simplex viruses 1 and 2 are among the most ubiquitous human infections persist lifelong in their host. Upon primary infection or reactivation from ganglia, spread by direct cell-cell contacts (cell-to-cell spread) thus escape host immune response. We have developed a monoclonal antibody (mAb 2c), which inhibits HSV cell-to-cell spread, thereby protecting lethal genital blindness animal models. In present study we designed nanoparticle-based vaccine to induce protective responses...