A5063825237- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Viral gastroenteritis research and epidemiology
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Bacillus and Francisella bacterial research
- Ocular Infections and Treatments
- Nosocomial Infections in ICU
- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- Child Nutrition and Water Access
- Global Maternal and Child Health
- Bacterial Identification and Susceptibility Testing
- Dental Research and COVID-19
- Mycobacterium research and diagnosis
- Diphtheria, Corynebacterium, and Tetanus
- Antibiotic Use and Resistance
- Surgical site infection prevention
- Antimicrobial Resistance in Staphylococcus
- Bacterial Genetics and Biotechnology
- Autoimmune Bullous Skin Diseases
- Endodontics and Root Canal Treatments
Universitätsmedizin Göttingen
2011-2023
University of Göttingen
1999-2019
Holy Family Hospital
2011
Robert Koch Institute
2011
Medical Mission Institute
2011
University Hospital of Zurich
1995
Associated Radiologists
1994
Clostridioides difficile infections (CDI) have emerged over the past decade causing symptoms that range from mild, antibiotic-associated diarrhea (AAD) to life-threatening toxic megacolon. In this study, we describe a multiple and isochronal (mixed) CDI caused by isolates DSM 27638, 27639 27640 already initially showed different morphotypes on solid media. The three belonging ribotypes (RT) 012 (DSM 27639) 027 27638 27640) were phenotypically characterized high quality closed genome...
Since early November 2016, the number of laboratory-confirmed norovirus infections reported in Germany has been increasing steeply. Here, we report detection and genetic characterisation an emerging recombinant, GII.P16-GII.2. This strain was frequently identified as cause sporadic cases well outbreaks nine federal states Germany. Our findings suggest that emergence GII.P16-GII.2 contributed to rising case numbers gastroenteritis
Systemic infections caused by Salmonella enterica are an ongoing public health problem especially in Sub-Saharan Africa. Essentially typhoid fever is associated with high mortality particularly because of the increasing prevalence multidrug-resistant strains. Thus, a rapid blood-culture based bacterial species diagnosis including immediate sub-differentiation various serovars mandatory. At present, MALDI-TOF intact cell mass spectrometry (ICMS) advances to widely used routine identification...
Abstract Objectives This study was a detailed investigation of Staphylococcus epidermidis clinical isolates exhibiting linezolid resistance. Methods Thirty-six linezolid-resistant S. from eight German hospitals, including suspected hospital-associated outbreaks between January 2012 and April 2013, were analysed with respect to their antimicrobial susceptibility the presence cfr and/or mutations in 23S rRNA, rplC, rplD rplV genes. Relatedness estimated by MLST SmaI macrorestriction analysis....
Some novel caries detection and excavation devices rely on the ability of bacteria to produce red fluorescing compounds. The aim this study was examine selected oral microorganisms emit fluorescence. Streptococcus mutans, S. oralis, salivarius, sobrinus, Lactobacillus fermentans, L. casei, rhamnosus, Actinomyces naeslundi, A. israelii, Prevotella intermedia, Fusobacterium nucleatum were inoculated onto Columbia agar with haemin vitamin K incubated anaerobically for up 7 days in dark....
Clostridioides difficile is the primary infectious cause of antibiotic-associated diarrhea. Local transmissions and international outbreaks this pathogen have been previously elucidated by bacterial whole-genome sequencing, but comparative genomic analyses at global scale were hampered lack specific bioinformatic tools. Here we introduce a publicly accessible database within EnteroBase ( http://enterobase.warwick.ac.uk ) that automatically retrieves assembles C. short-reads from public...
The identification and characterization of clinical Clostridioides difficile isolates with reduced fidaxomicin susceptibility.Agar dilution assays were used to determine MICs. Genome sequence data obtained by single-molecule real-time (SMRT) sequencing in addition amplicon rpoB rpoC alleles. Allelic exchange was introduce the identified mutation into C. 630Δerm. Replication rates, toxin A/B production spore formation determined from strain susceptibility.Out 50 isolates, isolate Goe-91...
Although infectious diseases still account for a high burden of morbidity and mortality in sub-Saharan Africa, simultaneous investigations on multiple infections affecting maternal child health are missing. We conducted cross-sectional, single-centre pilot study rural area Ghana to assess the infectiological profile during pregnancy. Screening 180 expectant mothers was done by vaginal swabs serology detect most common pregnancy-relevant infections. They were also interviewed potential risk...
Chemotaxonomic and 16S ribosomal DNA sequence analyses of four bacterial isolates from blood cultures patients with cardiac pacemaker implants sputa chronic lung infections clearly demonstrated that these bacteria belong to the genus Tsukamurella. DNA-DNA hybridization data, as well physiological characteristics isolates, indicate they are closely related a single species differs previously described members The name Tsukamurella tyrosinosolvens sp. nov. is proposed for new represented by...
Abstract Bacterial distribution and antimicrobial drug resistance were monitored in patients with bacterial bloodstream infections rural hospitals Ghana. In 2001–2002 2009, Salmonella enterica serovar Typhi was the most prevalent pathogen. Although S. isolates chloramphenicol resistant, all tested susceptible to ciprofloxacin.
Abstract Bacterial distribution and antimicrobial drug resistance were monitored in patients with bacterial bloodstream infections rural hospitals Ghana. In 2001–2002 2009, Salmonella enterica serovar Typhi was the most prevalent pathogen. Although S. isolates chloramphenicol resistant, all tested susceptible to ciprofloxacin.
Clostridioides (Clostridium) difficile infections (CDI) are considered worldwide as emerging health threat. Uptake of C. spores may result in asymptomatic carrier status or lead to CDI that could range from mild diarrhea, eventually developing into pseudomembranous colitis up a toxic megacolon often results high mortality. Most epidemiological studies date have been performed middle- and income countries. Beside others, the use antibiotics composition microbiome identified major risk factors...
Objective To evaluate the sonographic changes that occur in patients with chronic prostatitis and compare them those of non‐inflammatory prostatodynia using transrectal prostatic sonography (TPS). Patients methods In a prospective study, TPS findings were analysed 88 men 53 prostatodynia, all whom had undergone standardized diagnostic procedure to detect inflammation. Results A statistically significant accumulation calcifications unilateral seminal gland alterations was demonstrated...
Little is known regarding the epidemiology Clostridium difficile in developing countries. Fresh stool samples from patients with diarrhoea were cultured anaerobically. C. was detected nine (6.4%) of 141 (95% confidence interval 4.2-13.1), which seven (77.8%) children. HIV infection, prolonged hospitalization and antibiotic use independent factors associated occurrence gastrointestinal tract. Two toxigenic isolates typed as ribotype 045, other two had unknown ribotype. All susceptible to...
A strain of a previously undescribed non-lipophilic coryneform bacterium was isolated from pleural fluids patient with chronic renal failure, stroke and pneumonia. Slow fermentative acid production glucose, maltose sucrose, strong N-acetyl-β-glucosaminidase activity were the most characteristic features bacterium. Chemotaxonomic characterization unambiguously indicated that organism belonged to genus Corynebacterium. The results comparative 16S rRNA gene sequence analysis revealed isolate...
Over 350 000 patients are treated in German hospitals for sepsis or pneumonia each year. The rate of antibiotic use is high. growing problem drug resistance necessitates a reconsideration treatment strategies.Antibiotics were given liberally the years 2010 and 2011 312-bed hospital. Special training, standardized algorithms to prevent unnecessary orders, uniform recommendations used 2012 2013 lessen use. We retrospectively studied hospital's mortality figures microbiological findings analyze...
Clostridioides difficile, a Gram-positive spore-forming bacterium, is the leading cause of nosocomial diarrhea worldwide and therefore substantial burden to healthcare system. During past decade, hypervirulent PCR-ribotype (RT) 027 population emerged rapidly all over world, associated with both, increased severity mortality rates. It thus great importance identify epidemic strains such as RT027 fast possible. While commonly used diagnostic methods, e.g. multi locus sequence typing (MLST) or...