A5007353681- Genomics and Phylogenetic Studies
- Bacteriophages and microbial interactions
- Vibrio bacteria research studies
- Bacterial Genetics and Biotechnology
- Microbial Community Ecology and Physiology
- Microbial infections and disease research
- Bacillus and Francisella bacterial research
- Evolution and Genetic Dynamics
- Probiotics and Fermented Foods
- Insect Resistance and Genetics
- Enzyme Production and Characterization
- RNA and protein synthesis mechanisms
- Aquaculture disease management and microbiota
- Insect and Pesticide Research
- Clostridium difficile and Clostridium perfringens research
- Plant Pathogenic Bacteria Studies
- Anaerobic Digestion and Biogas Production
- Plant-Microbe Interactions and Immunity
- Plant Virus Research Studies
- Identification and Quantification in Food
- Gut microbiota and health
- Bacterial biofilms and quorum sensing
- Microbial metabolism and enzyme function
- Microbial Fuel Cells and Bioremediation
- Protist diversity and phylogeny
University of Göttingen
2014-2024
Kiel University
2020
GEOMAR Helmholtz Centre for Ocean Research Kiel
2020
Board of the Swiss Federal Institutes of Technology
2020
ETH Zurich
2020
Universität Ulm
2004
Genomics (United Kingdom)
2004
Bacillus amyloliquefaciens FZB42 is a Gram-positive, plant-associated bacterium, which stimulates plant growth and produces secondary metabolites that suppress soil-borne pathogens. Its 3,918-kb genome, containing an estimated 3,693 protein-coding sequences, lacks extended phage insertions, occur ubiquitously in the closely related subtilis 168 genome. The B. genome reveals unexpected potential to produce metabolites, including polyketides bacillaene difficidin. More than 8.5% of devoted...
Clostridium ljungdahlii is an anaerobic homoacetogen, able to ferment sugars, other organic compounds, or CO 2 /H and synthesis gas (CO/H ). The latter feature makes it interesting microbe for the biotech industry, as important bulk chemicals proteins can be produced at expense of , thus combining industrial needs with sustained reduction in atmosphere. Sequencing complete genome C. revealed that comprises 4,630,065 bp one largest clostridial genomes known date. Experimental data silico...
The H2-oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence organic growth substrates, on H2 and CO2 as its sole sources energy carbon. R. first attracted biotechnological interest nearly 50 years ago with realization that organism's ability to produce store large amounts poly[R-(–)-3-hydroxybutyrate] other polyesters could be harnessed make biodegradable plastics. Here we report complete genome sequence two...
ABSTRACT The environmental strain Bacillus amyloliquefaciens FZB42 promotes plant growth and suppresses pathogenic organisms present in the rhizosphere. We sampled sequenced genome of identified 2,947 genes with >50% identity on amino acid level to corresponding subtilis 168. Six large gene clusters encoding nonribosomal peptide synthetases (NRPS) polyketide synthases (PKS) occupied 7.5% whole genome. Two PKS one NRPS were unique insertions are not B. Matrix-assisted laser desorption...
Clostridioides difficile infections (CDI) have emerged over the past decade causing symptoms that range from mild, antibiotic-associated diarrhea (AAD) to life-threatening toxic megacolon. In this study, we describe a multiple and isochronal (mixed) CDI caused by isolates DSM 27638, 27639 27640 already initially showed different morphotypes on solid media. The three belonging ribotypes (RT) 012 (DSM 27639) 027 27638 27640) were phenotypically characterized high quality closed genome...
Clostridium kluyveri is unique among the clostridia; it grows anaerobically on ethanol and acetate as sole energy sources. Fermentation products are butyrate, caproate, H2. We report here genome sequence of C. kluyveri, which revealed new insights into metabolic capabilities this well studied organism. A membrane-bound energy-converting NADH:ferredoxin oxidoreductase (RnfCDGEAB) a cytoplasmic butyryl-CoA dehydrogenase complex (Bcd/EtfAB) coupling reduction crotonyl-CoA to with ferredoxin...
Gluconobacter oxydans is unsurpassed by other organisms in its ability to incompletely oxidize a great variety of carbohydrates, alcohols and related compounds. Furthermore, the organism used for several biotechnological processes, such as vitamin C production. To further our understanding overall metabolism, we sequenced complete genome G. 621H. The chromosome consists 2,702,173 base pairs contains 2,432 open reading frames. In addition, five plasmids were identified that comprised 232...
Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as harmless commensal although has been implicated in acne vulgaris formation. The entire genome sequence this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, pore-forming factors. Surface-associated other immunogenic factors have...
The ability of a bacterial cell to monitor and adaptively respond its environment is crucial for survival. After one- two-component systems, extracytoplasmic function (ECF) sigma factors - the largest group alternative represent third fundamental mechanism signal transduction, with about six such regulators on average per genome. Together their cognate anti-sigma factors, they highly modular design that primarily facilitates transmembrane transduction. A comprehensive analysis ECF factor...
Uropathogenic Escherichia coli (UPEC) strain 536 (O6:K15:H31) is one of the model organisms extraintestinal pathogenic E. (ExPEC). To analyze this strain's genetic basis urovirulence, we sequenced entire genome and compared data with sequence UPEC CFT073 (O6:K2:H1) to available genomes nonpathogenic MG1655 (K-12) enterohemorrhagic coli. The approximately 292 kb smaller than that CFT073. Genomic differences between both are mainly restricted large pathogenicity islands, parts which unique or...
Tetanus disease is one of the most dramatic and globally prevalent diseases humans vertebrate animals, has been reported for over 24 centuries. The manifestation disease, spastic paralysis, caused by second poisonous substance known, tetanus toxin, with a human lethal dose ≈1 ng/kg. Fortunately, this successfully controlled through immunization toxoid; nevertheless, according to World Health Organization, an estimated 400,000 cases still occur each year, mainly neonatal tetanus. causative...
The genome of <i>Bacillus licheniformis </i>DSM13 consists a single chromosome that has size 4,222,748 base pairs. average G+C ratio is 46.2%. 4,286 open reading frames, 72 tRNA genes, 7 rRNA operons and 20 transposase genes were identified. shows marked co-linearity with subtilis </i>but contains defined inserted regions can be identified at the sequence as well functional level. <i>B. well-conserved secretory system, no polyketide biosynthesis, but able to form...
ABSTRACT Methanosphaera stadtmanae has the most restricted energy metabolism of all methanogenic archaea. This human intestinal inhabitant can generate methane only by reduction methanol with H 2 and is dependent on acetate as a carbon source. We report here genome sequence M. , which was found to be composed 1,767,403 bp an average G+C content 28% harbor 1,534 protein-encoding sequences (CDS). The lacks 37 CDS present in genomes other methanogens. Among these are for synthesis molybdopterin...
The euryarchaea Picrophilus torridus and oshimae are able to grow around pH 0 at up 65°C, thus they represent the most thermoacidophilic organisms known. Several features that may contribute survival strategy of P. were deduced from analysis its 1.55-megabase genome. has smallest genome among nonparasitic aerobic microorganisms growing on organic substrates simultaneously highest coding density thermoacidophiles. An exceptionally high ratio secondary over ATP-consuming primary transport...
From pMOL28, one of the two heavy metal resistance plasmids Alcaligenes eutrophus strain CH34, we cloned an EcoRI-PstI fragment into plasmid pVDZ'2. This hybrid conferred inducible nickel and cobalt (cnr) in distinct plasmid-free A. hosts, strains AE104 H16. Resistances were not expressed Escherichia coli. The nucleotide sequence 8.5-kb (8,528 bp) revealed seven open reading frames; these, cnrB cnrA, assigned with respect to size location polypeptides E. coli under control bacteriophage T7...
ABSTRACT Most naturally occurring biofilms contain a vast majority of microorganisms which have not yet been cultured, and therefore we little information on the genetic content these communities. Therefore, initiated work to characterize complex metagenome model drinking water grown rubber-coated valves by employing three different strategies. First, sequence analysis 650 16S rRNA clones indicated high diversity within biofilm communities, with microbes being closely related Proteobacteria...
Anthrax is a fatal disease caused by strains of Bacillus anthracis. Members this monophyletic species are non motile and all characterized the presence four prophages nonsense mutation in plcR regulator gene. Here we report complete genome sequence strain isolated from chimpanzee that had died with clinical symptoms anthrax. Unlike classic B. anthracis, was lacked prohages mutation. Four replicons were identified, chromosome three plasmids. Comparative analysis revealed resembles those...
Rhizobium sp. strain NGR234 is a unique alphaproteobacterium (order Rhizobiales) that forms nitrogen-fixing nodules with more legumes than any other microsymbiont. We report here the 3.93-Mbp chromosome (cNGR234) encodes most functions required for cellular growth. Few essential are encoded on 2.43-Mbp megaplasmid (pNGR234b), and none present second 0.54-Mbp symbiotic plasmid (pNGR234a). Among many striking features, 6.9-Mbp genome different secretion systems known rhizobia probably...
In recent years, multiresistant Pasteurella multocida isolates from bovine respiratory tract infections have been identified. These exhibited resistance to most classes of antimicrobial agents commonly used in veterinary medicine, the genetic basis which, however, is largely unknown.Genomic DNA a representative P. isolate was subjected whole genome sequencing. Genes predicted by YACOP program, compared with SWISSProt/EMBL databases and manually curated using annotation software ERGO....
Bacteria lose or gain genetic material and through selection, new variants become fixed in the population. Here we provide first, genome-wide example of a single bacterial strain's evolution different deliberately colonized patients surprising insight that hosts appear to personalize their microflora. By first obtaining complete genome sequence prototype asymptomatic bacteriuria strain E. coli 83972 then resequencing its descendants after therapeutic bladder colonization patients, identified...
Sourdough has played a significant role in human nutrition and culture for thousands of years is still eminent importance diet the bakery industry. Lactobacillus sanfranciscensis predominant key bacterium traditionally fermented sourdoughs.The genome L. TMW 1.1304 isolated from an industrial sourdough fermentation was sequenced with combined Sanger/454-pyrosequencing approach followed by gap closing walking on fosmids. The sequencing data revealed circular chromosomal sequence 1,298,316 bp...