A5077368917- Acne and Rosacea Treatments and Effects
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Dermatology and Skin Diseases
- Engineering and Materials Science Studies
- Corporate Governance and Management
- Flexible and Reconfigurable Manufacturing Systems
- Antimicrobial Resistance in Staphylococcus
- Orthopedic Infections and Treatments
- Herpesvirus Infections and Treatments
- Bacterial biofilms and quorum sensing
- Civil and Structural Engineering Research
- Clostridium difficile and Clostridium perfringens research
- Legionella and Acanthamoeba research
- Botulinum Toxin and Related Neurological Disorders
- Diphtheria, Corynebacterium, and Tetanus
- melanin and skin pigmentation
- Religion, Theology, and Education
- Oral Health Pathology and Treatment
- Genetic and phenotypic traits in livestock
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Vibrio bacteria research studies
- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
Aarhus University
2016-2025
Ostfalia University of Applied Sciences
2011-2024
Institut Pasteur
2004-2014
Max Planck Institute for Infection Biology
2008-2014
Max Planck Society
2008-2012
University of Göttingen
2000-2010
Centre National de la Recherche Scientifique
2004-2008
Department of Genomes & Genetics
2006
Universität Ulm
2004
European Institute For Research and Strategic Studies In Telecommunications
2002
Clostridium kluyveri is unique among the clostridia; it grows anaerobically on ethanol and acetate as sole energy sources. Fermentation products are butyrate, caproate, H2. We report here genome sequence of C. kluyveri, which revealed new insights into metabolic capabilities this well studied organism. A membrane-bound energy-converting NADH:ferredoxin oxidoreductase (RnfCDGEAB) a cytoplasmic butyryl-CoA dehydrogenase complex (Bcd/EtfAB) coupling reduction crotonyl-CoA to with ferredoxin...
Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as harmless commensal although has been implicated in acne vulgaris formation. The entire genome sequence this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, pore-forming factors. Surface-associated other immunogenic factors have...
Uropathogenic Escherichia coli (UPEC) strain 536 (O6:K15:H31) is one of the model organisms extraintestinal pathogenic E. (ExPEC). To analyze this strain's genetic basis urovirulence, we sequenced entire genome and compared data with sequence UPEC CFT073 (O6:K2:H1) to available genomes nonpathogenic MG1655 (K-12) enterohemorrhagic coli. The approximately 292 kb smaller than that CFT073. Genomic differences between both are mainly restricted large pathogenicity islands, parts which unique or...
Propionibacterium acnes and Staphylococcus epidermidis live in close proximity on human skin, both bacterial species can be isolated from normal acne vulgaris-affected skin sites. The antagonistic interactions between the two are poorly understood, as well potential significance of interferences for microbiota. Here, we performed simultaneous antagonism assays to detect inhibitory activities multiple isolates species. Selected strains were sequenced identify genomic basis their antimicrobial...
Tetanus disease is one of the most dramatic and globally prevalent diseases humans vertebrate animals, has been reported for over 24 centuries. The manifestation disease, spastic paralysis, caused by second poisonous substance known, tetanus toxin, with a human lethal dose ≈1 ng/kg. Fortunately, this successfully controlled through immunization toxoid; nevertheless, according to World Health Organization, an estimated 400,000 cases still occur each year, mainly neonatal tetanus. causative...
Adaptation to the host environment and exploitation of cell functions are critical success intracellular pathogens. Here, insight these virulence mechanisms was obtained for first time from transcriptional program human pathogen Legionella pneumophila during infection its natural host, Acanthamoeba castellanii. The biphasic life cycle L. reflected by a major shift in gene expression replicative transmissive phase, concerning nearly half genes predicted genome. However, three different...
Anthrax is a fatal disease caused by strains of Bacillus anthracis. Members this monophyletic species are non motile and all characterized the presence four prophages nonsense mutation in plcR regulator gene. Here we report complete genome sequence strain isolated from chimpanzee that had died with clinical symptoms anthrax. Unlike classic B. anthracis, was lacked prohages mutation. Four replicons were identified, chromosome three plasmids. Comparative analysis revealed resembles those...
Legionella pneumophila is an opportunistic human pathogen that replicates within environmental amoebae including Acanthamoeba castellanii and Dictyostelium discoideum. The Icm/Dot type IV secretion system promotes phagocytosis intracellular replication of L. in endoplasmic reticulum-derived 'Legionella-containing vacuole' (LCV). adopts a biphasic life cycle consisting replicative growth phase transmissive (stationary) phase, the latter which characterized by preferential expression genes...
To transit from intra- to extracellular environments, Legionella pneumophila differentiates a replicative/non-virulent transmissive/virulent form using the two-component system LetA/LetS and global repressor protein CsrA. While investigating how both regulators act co-ordinately we characterized two ncRNAs, RsmY RsmZ, that link CsrA regulatory networks. We demonstrate LetA directly regulates their expression show RsmZ are functional in Escherichia coli able bind vitro. Single mutants have no...
The anaerobic Gram-positive bacterium Propionibacterium acnes is a human skin commensal that resides preferentially within sebaceous follicles; however, it also exhibits many traits of an opportunistic pathogen, playing roles in variety inflammatory diseases such as acne vulgaris. To date, the underlying disease-causing mechanisms remain ill-defined and knowledge P. virulence factors remains scarce. Here, we identified proteins secreted during cultivation range clinical isolates, spanning...
The Gram-positive anaerobic bacterium Propionibacterium acnes is a prevalent member of the normal skin microbiota human adults. In addition to its suspected role in acne vulgaris it involved variety opportunistic infections. Multi-locus sequence-typing (MLST) schemes identified distinct phylotypes associated with health and disease. Being based on 8 9 house-keeping genes these MLST have high discriminatory power, but their application time- cost-intensive. Here we describe single-locus...
ABSTRACT The bacterium Streptococcus pneumoniae is one of the leading causes fatal infections affecting humans. Intriguingly, phylogenetic analysis shows that species constitutes evolutionary lineage in a cluster otherwise commensal mitis strains, with which humans live harmony. In comparative 35 genomes, including analyses all predicted genes, we have shown pathogenic pneumococcus has evolved into master genomic flexibility while lineages nonpathogenic S. secured harmonious coexistence...
The anaerobic Gram-positive bacterium Propionibacterium acnes is a human skin commensal that occasionally associated with inflammatory diseases. Recent work has indicated evolutionary distinct lineages of P. play etiologic roles in disease while others are maintenance homeostasis. To shed light on the molecular basis for differential strain properties, we carried out genomic and transcriptomic analysis strains. We sequenced genome 266, type I-1a strain. Comparative 266 four other strains...
Abstract BACKGROUND Prostatic inflammation has been linked to a number of prostatic diseases such as benign hyperplasia (BPH), prostatitis syndromes, and prostate cancer. Major unanswered questions include what pathogenic mechanisms, bacterial infections, may drive the accumulation inflammatory infiltrates in human prostate, how might contribute disease. To study this potential link an vivo system, we developed mouse model long‐term bacteria‐induced chronic using prostatectomy‐derived strain...
The skin is colonized by a large number of microorganisms, most which are beneficial or harmless. However, disease states have specific microbiome compositions that different from those healthy skin. Gut modulation through fecal transplant has been proven as valid therapeutic strategy in diseases such Clostridium difficile infections. Therefore, techniques to modulate the composition may become an interesting option affecting psoriasis acne vulgaris.Here, we used mixtures components alter...
Two intergenic spacers, trnT‐trnL and trnL‐trnF , the trnL intron of cpDNA were sequenced to study phylogenetic relationships biogeography 73 Lepidium taxa. Insertions/deletions ≥3 bp (base pairs) provided reliable information whereas indels ≤2 bp, probably originating from slipped‐strand mispairing, are prone parallelism in context our framework. For first time, an hypothesis genus is proposed based on molecular phylogeny, contrast previous classification schemes into sections greges (the...