A5065231641- Vector-borne infectious diseases
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Dermatological diseases and infestations
- Vector-Borne Animal Diseases
- Insect and Pesticide Research
- Toxin Mechanisms and Immunotoxins
- Rabies epidemiology and control
- Bartonella species infections research
- Insect symbiosis and bacterial influences
- Leptospirosis research and findings
- Yersinia bacterium, plague, ectoparasites research
- Zoonotic diseases and public health
- Venomous Animal Envenomation and Studies
- Herpesvirus Infections and Treatments
- Malaria Research and Control
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Toxoplasma gondii Research Studies
- Plant Virus Research Studies
- Reproductive tract infections research
- COVID-19 Clinical Research Studies
- Bacterial Identification and Susceptibility Testing
- Whipple's Disease and Interleukins
- Parasites and Host Interactions
Johns Hopkins University
2010-2024
Johns Hopkins Medicine
2010-2024
Uniformed Services University of the Health Sciences
2016-2024
Unifor
2023
Walter Reed National Military Medical Center
2016-2022
Makerere University
2021
Infectious Diseases Institute
2021
Weill Cornell Medicine
2018
NewYork–Presbyterian Hospital
2018
Cornell University
2018
The genera Anaplasma, Ehrlichia, Cowdria, Neorickettsia and Wolbachia encompass a group of obligate intracellular bacteria that reside in vacuoles eukaryotic cells were previously placed taxa based upon morphological, ecological, epidemiological clinical characteristics. Recent genetic analyses 16S rRNA genes, groESL surface protein genes have indicated the existing designations are flawed. All gene sequences deposited GenBank prior to 2000 selected thereafter aligned phylogenetic trees...
Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as ehrlichiosis), and babesiosis were prepared by an expert panel Infectious Diseases Society America. These updated replace previous treatment published in 2000 (Clin Infect Dis 2000; 31[Suppl 1]:1-14). The are intended use health care providers who either have these infections or may be at risk them. For each Ixodes tickborne infections, information is provided about...
Tickborne rickettsial diseases continue to cause severe illness and death in otherwise healthy adults children, despite the availability of low-cost, effective antibacterial therapy. Recognition early clinical course is critical because this period when therapy most effective. Early signs symptoms these illnesses are nonspecific or mimic other illnesses, which can make diagnosis challenging. Previously undescribed tickborne be recognized, since 2004, three additional agents have been...
human granulocytic ehrlichiosis is a potentially fatal tick-borne infection that has recently been described. This acute febrile illness characterized by myalgias, headache, thrombocytopenia, and elevated serum aminotransferase levels. The disease difficult to diagnose because the symptoms are nonspecific, intraleukocytic inclusions (morulae) may not be seen, serologic results often initially negative. Little known about causative agent it never cultivated.
ABSTRACT We propose genetic guidelines for the classification of rickettsial isolates at genus, group, and species levels by using sequences 16S rRNA ( rrs ) gene four protein-coding genes, gltA , ompA ompB genes D. To be classified as a member genus Rickettsia an isolate should exhibit degrees homology with any 20 studied ≥98.1 ≥86.5%, respectively. A typhus group fulfill least two following criteria: pairwise nucleotide sequence homologies D either typhi or prowazekii ≥99.4, ≥96.6, ≥92.4,...
Journal Article Ixodes dammini as a Potential Vector of Human Granulocytic Ehrlichiosis Get access Preeti Pancholi, Pancholi Search for other works by this author on: Oxford Academic PubMed Google Scholar Chris P. Kolbert, Kolbert Paul D. Mitchell, Mitchell Kurt Reed, Reed J. Stephen Dumler, Dumler Johann S. Bakken, Bakken Sam R. Telford, III, III David H. Persing Reprints or correspondence: Dr. Persing, Division Clinical Microbiology, Mayo Clinic and Foundation, Rochester, MN 55905. The...
Human granulocytic ehrlichiosis (HGE) was recently described in North America. It is caused by an Ehrlichia species closely related to phagocytophila and equi, recognized infect mostly ruminants horses, respectively. The vector America the tick Ixodes scapularis, which also of Lyme disease agent, Borrelia burgdorferi. Previous serologic studies patients with a diagnosis borreliosis indicate that HGE may exist Europe. We report first documented case established seroconversion E. equi agent...
Homology in the 16S rDNAs shows that agent of human granulocytic ehrlichiosis (HGE) is closely related to veterinary pathogens Erlichia equi and phagocytophila. After HGE, patients develop antibodies reactive with E. phagocytophila; thus, we hypothesized these species are share significant antigenicity. Antisera from humans, horses, dogs, cattle were tested by indirect fluorescent-antibody assay (IFA) for other ehrlichiae immunoblot identify specific reactions equi. All convalescent-phase...
Identification of ELB agent-infected fleas and rodents within several foci murine typhus in the United States has prompted a retrospective investigation for this agent among human patients. This is recently described rickettsia which indistinguishable from Rickettsia typhi with currently available serologic reagents. Molecular analysis 17-kDa antigen gene citrate synthase discriminated bacterium other group spotted fever rickettsiae. Current sequencing its 16S ribosomal DNA indicates...
--The clinical and laboratory features of patients with murine typhus have not been extensively reviewed since 1946. We updated these findings in from south Texas who were examined by modern methods 1980 through 1987.--Patients identified serological this case series, clinical, epidemiologic, laboratory, therapeutic data compiled analyzed.--The majority (77 80) a primary care community hospital setting; the remainder (3 ambulatory outpatients.--From 1987, total 345 diagnosed typhus; 90 seen...
Centrllobular emphysema (CLE) is a disease defined pathologically. Assessment of the accuracy high resolution computed tomography (CT) in diagnosis centrilobular has been hampered by lack pathologic correlation. We applied to 20 postmortem lung specimens fixed method that allows for direct one-to-one pathologic-radiologic The degree centrilobuler was assessed radiologically on visual grading system based nonperipheral low-attenuation areas. lungs were then sectioned along plane CT image, and...
Anaplasma phagocytophilum is a gram-negative, tick-transmitted, obligate intracellular bacterium that elicits acute febrile diseases in humans and domestic animals. In contrast to the United States, human granulocytic anaplasmosis seems be rare disease Europe despite initial recognition of A. as causative agent tick-borne fever European sheep cattle. Considerable strain variation has been suggested occur within this species, because isolates from animals differed their pathogenicity for...
Intracellular bacteria have evolved mechanisms that promote survival within hostile host environments, often resulting in functional dysregulation and disease. Using the Anaplasma phagocytophilum–infected granulocyte model, we establish a link between chromatin modifications, defense gene transcription intracellular bacterial infection. Infection of THP-1 cells with A. phagocytophilum led to silencing expression. Histone deacetylase 1 (HDAC1) expression, activity binding promoters...
ABSTRACT Coevolution of intracellular bacterial pathogens and their host cells resulted in the appearance effector molecules that when translocated into cell modulate its function, facilitating survival within hostile environment. Some these effectors interact with chromatin other nuclear components. In this report, we show AnkA protein Anaplasma phagocytophilum , which is nucleus, interacts gene regulatory regions involved downregulating expression CYBB (gp91 phox ) key defense genes....