A5003360427- Vector-borne infectious diseases
- Viral Infections and Vectors
- Insect and Pesticide Research
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Yersinia bacterium, plague, ectoparasites research
- Insect symbiosis and bacterial influences
- Cell Adhesion Molecules Research
- Signaling Pathways in Disease
- Blood disorders and treatments
- Toxin Mechanisms and Immunotoxins
- Bartonella species infections research
- Trypanosoma species research and implications
- DNA Repair Mechanisms
- Cardiovascular Effects of Exercise
- Immune Response and Inflammation
- Animal Ecology and Behavior Studies
- Plant Virus Research Studies
- Botany, Ecology, and Taxonomy Studies
- Cancer therapeutics and mechanisms
- Ethnobotanical and Medicinal Plants Studies
- Sports injuries and prevention
- Plant Parasitism and Resistance
- Insect and Arachnid Ecology and Behavior
- Dermatological diseases and infestations
Centers for Disease Control and Prevention
2016-2025
National Center for Emerging and Zoonotic Infectious Diseases
2016-2025
Vector (United States)
2015
University of Utah
2001-2014
Rocky Mountain University of Health Professions
2014
The Centers
2010
State Research Center for Applied Microbiology and Biotechnology
2009
Hospital de Santa Maria
2008
Two species of the genus Borrelia, Borrelia bissettiae sp. nov. and californiensis nov., were first described by Postic co-workers on basis genetic analyses several loci. Multilocus sequence analysis eight housekeeping loci confirmed that these two genomospecies are distinct members burgdorferi sensu lato complex. B. was initially in transmission cycles involving Neotoma fuscipes wood rats Ixodes pacificus ticks California, mexicana spinipalpis Colorado. The preferred host appears to be...
The invasive, human-biting Asian longhorned tick, Haemaphysalis longicornis, was detected in New Jersey the eastern United States August of 2017 and by November 2018 this tick had been recorded from 45 counties across 9 states, primarily along Eastern Seaboard. establishment H. longicornis has raised questions how commonly it will bite humans which native pathogens may naturally infect tick. There also is a need for experimental vector competence studies with to determine if can acquire...
Abstract A previous laboratory study using Haemaphysalis longicornis Neumann (Acari: Ixodidae) ticks of North American origin showed that larvae could acquire the Lyme disease spirochete, Borrelia burgdorferi sensu stricto (s.s.) (Spirochaetales: Spirochaetaceae) while feeding to completion on infected mice. However, infection was lost during molt nymphal stage. Nonetheless, questing H. nymphs and adults collected by drag sampling in northeastern United States have been reported with B. s.s....
Borrelia mayonii is a newly described member of the burgdorferi sensu lato complex that vectored by black-legged tick (Ixodes scapularis Say) and cause Lyme disease in Minnesota Wisconsin. Vertebrate reservoir hosts involved enzootic maintenance B. have not yet been identified. Here, we describe first isolation from naturally infected white-footed mice (Peromyscus leucopus Rafinesque) an American red squirrel (Tamiasciurus hudsonicus Erxleben) Minnesota, thus implicating these species as...
Tick-borne pathogens transmitted by Ixodes scapularis Say (Acari: Ixodidae), also known as the deer tick or blacklegged tick, are increasing in incidence and geographic distribution United States. We examined risk of tick-borne disease exposure 9 national parks across six Northeastern Mid-Atlantic States District Columbia 2014 2015. To assess recreational to park visitors, we sampled for ticks along frequently used trails calculated density I. nymphs (DON) infected (DIN). determined nymphal...
Nymphal Ixodes scapularis Say are the principal vectors of Lyme disease spirochetes (Borrelia burgdorferi sensu stricto) in eastern United States. Physicians frequently face decision whether or not to administer prophylactic antibiotics human tick bite victims endemic regions, based on overall probability that such bites will result infection with B. s.s. We evaluated transmission dynamics during key third day nymphal I. feeding, when risk rapidly increases. The cumulative 50% infected ticks...
Ixodes scapularis, commonly known as the blacklegged tick, is responsible for transmitting Lyme disease (caused by Borrelia burgdorferi), most common vector-borne in United States (Centers Disease Control and Prevention 2014). The tick can also transmit Anaplasma phagocytophilum (the etiologic agent of human granulocytic anaplasmosis), Babesia microti causative babesiosis), miyamotoi (a relapsing fever Borrelia), deer virus. In northeastern U.S., highest risk exposure to likely peridomestic,...
Forests in urban landscapes differ from their rural counterparts ways that may alter vector-borne disease dynamics. In forest fragments, tick-borne pathogen prevalence is not well characterized; mitigating risk densely-populated requires understanding ecological factors affect prevalence. We trapped blacklegged tick (Ixodes scapularis) nymphs fragments on the East Coast of United States and used multiplex real-time PCR assays to quantify four zoonotic, pathogens. Bayesian logistic regression...
The Centers for Disease Control and Prevention's national tick tick-borne pathogen surveillance program collects information to better understand the regional distribution, prevalence, exposure risk of host-seeking medically important ticks in United States. A recently developed next generation sequencing (NGS) targeted multiplex PCR amplicon (MPAS) assay has enhanced detection capabilities Ixodes-associated human pathogens found Ixodes scapularis pacificus compared routinely used real-time...
The burden of tick-borne diseases continues to increase in the United States. Tick surveillance has been implemented monitor changes distribution and prevalence human disease-causing pathogens ticks that frequently bite humans. Such efforts require accurate identification species highly sensitive specific assays can detect differentiate from genetically similar microbes have not demonstrated be pathogenic We describe a modification next generation sequencing pathogen detection assay includes...
A field trial was conducted in a Lyme disease-endemic area of New Jersey to determine the efficacy doxycyline hyclate rodent bait prophylactically protect and cure small-mammal reservoirs reduce infection rates questing Ixodes scapularis ticks for Borrelia burgdorferi Anaplasma phagocytophilum. The doxycycline-laden formulated at concentration 500 mg/kg delivered during immature tick feeding season rodent-targeted boxes. percentage infected small mammals recovered from treated areas after 2...
Ixodes scapularis, the tick vector of Lyme disease spirochete, is distributed over most eastern United States, but >80% all cases occur in northeast. The role that genetic differences between northern and southern populations play explaining this disparate distribution unclear. present study was conducted with 1,155 SNP markers eight nuclear genes; 16S mitochondrial gene examined for comparison earlier studies. We 350 I. scapularis from 7 states covering a representative area species. A...
In 2011, Ehrlichia muris eauclairensis (EME) was described as a human pathogen spread by the blacklegged tick, Ixodes scapularis. Until very recently, its reported distribution limited to upper midwestern United States, mainly in Minnesota and Wisconsin. this study, we report detection of EME DNA 4 16,146 biting I. scapularis ticks submitted from Massachusetts passive tick surveillance program. Active yielded evidence local transmission northeastern States through 2 461 host-seeking nymphs,...
The relapsing fever spirochete, Borrelia miyamotoi, is increasingly recognized as a cause of human illness (hard tick-borne fever) in the United States. We previously demonstrated that single nymphs blacklegged tick, Ixodes scapularis, can transmit B. miyamotoi to experimental hosts. However, two recent epidemiological studies from Northeastern States indicate cases hard peak during late summer, after spring for nymphal tick activity but coincident with seasonal period larval ticks...
To determine the prevalence of Borrelia burgdorferi in British Columbian ticks, fieldwork was conducted over a 2-year period. In all, 893 ticks (Ixodes pacificus, I. angustus, soricis, Ixodes spp., and Dermacentor andersoni) different life stages were retrieved from 483 small rodents (Peromyscus maniculatus, Perognathus parvus, Reithrodontomys megalotis). B. DNA detected 5 out 359 tick pools, 41 mice serologically confirmed to have antibodies against burgdorferi. These results consistent...