A5009644919- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood Coagulation and Thrombosis Mechanisms
- Blood disorders and treatments
- Acute Ischemic Stroke Management
- Acute Myeloid Leukemia Research
- Maternal and fetal healthcare
- Atrial Fibrillation Management and Outcomes
- Immunodeficiency and Autoimmune Disorders
- Mechanical Circulatory Support Devices
- Pituitary Gland Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Blood properties and coagulation
- Adrenal Hormones and Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Respiratory Support and Mechanisms
- Adrenal and Paraganglionic Tumors
- Hemophilia Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Sepsis Diagnosis and Treatment
- Maternal and Perinatal Health Interventions
- Hematological disorders and diagnostics
- Peroxisome Proliferator-Activated Receptors
University Hospital Carl Gustav Carus
2004-2025
TU Dresden
2011-2025
Carl Gustav Carus-Institut
2022
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2021-2022
Baylor College of Medicine
1999-2009
Deutsches Herzzentrum der Charité
2005
Pheochromocytomas are rare catecholamine-producing tumors derived in more than 30% of cases from mutations 9 tumor-susceptibility genes identified to date, including von Hippel-Lindau tumor suppressor (VHL); succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB); and D, integral membrane protein (SDHD). Testing multiple is often undertaken at considerable expense before a mutation detected. This study assessed whether measurements plasma metanephrine, normetanephrine,...
Abstract Epidemiologic studies have indicated that high intake of saturated fat and/or animal increases the risk colon and breast cancer. Omega‐3 PUFAs in fish oil (FO) can inhibit growth human cancer cells vitro vivo . These effects are related to uptake eicosapentaenoic acid (EPA) docosahexaenoic (DHA) into cellular substrate pool their competitive metabolism with arachidonic (AA) at cyclooxygenase 5‐lipoxygenase levels. The metabolites EPA DHA less inflammatory immunosuppressant potency...
Context:Pheochromocytomas and paragangliomas (PPGLs) are diagnosed earlier in patients with hereditary than sporadic disease. Whether other factors influence age at diagnosis is unclear.
Background: Direct oral anticoagulants (DOAC) are associated with an increased risk of hematoma expansion (HE) in spontaneous intracerebral hemorrhage (ICH). However, the critical DOAC level influencing this remains unclear. This study investigates impact levels on HE patients DOAC-associated ICH. Methods: We conducted a retrospective analysis ICH who had DOAC-calibrated anti-Xa or -IIa activity measured upon admission. Patients were categorized based clinically established cutoff for...
Abstract Acute Respiratory Distress Syndrome (ARDS) is common in COVID-19 patients and associated with high mortality. The aim of this observational study was to describe patients’ characteristics outcome, identifying potential risk factors for in-hospital mortality developing Long-COVID symptoms. This retrospective included all ARDS (cARDS) the period from March 2020 2021 who were invasively ventilated at intensive care unit (ICU) University Hospital Dresden, Germany. Between October...
Abstract Aim This official guideline was coordinated and published by the German Society of Gynaecology Obstetrics (DGGG). The aims to provide a consensus-based overview diagnosis management peripartum bleeding based on an evaluation relevant literature. Methods S2k-guideline developed representative members from different medical professions behalf guidelines commission DGGG, OEGGG SGGG using structured consensus process. Recommendations for definition, risk stratification, prevention,...
Abstract Background SARS-CoV-2 infections are suspected to trigger the coagulation system through various pathways leading a high incidence of thromboembolic complications, hypercoagulation and impaired fibrinolytic capacity were previously identified as potentially mechanisms. A reliable diagnostic tool for detecting both is still under discussion. This retrospective study aimed examine prognostic relevance early viscoelastic testing compared conventional laboratory tests in COVID-19...
Abstract Acquired von Willebrand disease (aVWD) is frequently observed in patients with the need for extracorporeal membrane oxygenation (ECMO). aVWD can be treated by plasma-derived concentrates containing factor VIII (FVIII) and/or (VWF) and recombinant VWF concentrate as well adjuvant therapies such tranexamic acid desmopressin. However, all of these therapeutic options possibly cause thromboembolism. Therefore, optimal treatment remains uncertain. This report presents a case 16-year-old...
Background: We first describe a patient who developed urosepsis from an ordinary urinary tract infection.In this case, the new hematological parameters of immature leukocytes, that is, high-fluorescence lymphocyte cell (HFLC) and granulocyte (IG) counts peaked early, whereas established infection parameters, C-reactive protein (CRP) total white blood count showed less dynamic regarding therapy.Methods: To investigate phenomenon in greater detail, novel HFLC IG are investigated...
Exosomes are nano-sized membranous vesicles of endosomal origin that carry nucleic acids, lipids and proteins. The cargo exosomes is cell specific the release these uptake by an acceptor seen as a vital element cell-cell communication. Here, we sought to investigate diagnostic prognostic value expression glypican 3 (GPC3) on primary gastro-esophageal adenocarcinoma (GEA) tissue (tGPC3) corresponding serum (eGPC3). Circulating were extracted from samples 49 patients with GEA 56 controls....
Summary A considerable proportion of patients with chronic myeloid leukaemia (CML) may present at diagnosis high platelet counts. This result in thrombosis or bleeding complications due to binding von Willebrand factor (VWF) multimers platelets. Paediatric CML is very rare and no systematic investigation on clinical elevated platelets has been reported. Data count associated haemostaseological were retrospectively analysed a cohort 156 children CML. Fifty‐one percent (81/156) presented...
Point of care (POC) devices are increasingly used in the ICU and anesthesia. Besides POC-devices for blood gas analysis, several available coagulation measurements. Although basic principles thromboelastographic measurements not novel, some promising developments were made during last decade improving both user-friendliness measurement reliability. For instance, POC activated clotting time (ACT) heparin monitoring is still regarded as standard-of-care cardiac interventions surgery. In field...
Inborn errors of immunity manifest with susceptibility to infection but may also present immune dysregulation only. According the European Society for Immunodeficiencies Registry about 50% inborn are classified as common variable immunodeficiencies (CVID). In only few CVID patients monogenic causes identified. IFN regulatory factor-2 binding protein 2 (IRF2BP2) is one 20 known genes associated phenotypes and has been reported in two families so far. We report another IRF2BP2-deficient...
Increasing evidences show that beyond its role in coagulation, endothelial protein C receptor (EPCR) interferes with carcinogenesis. Pro-carcinogenic effects of EPCR were linked a raised generation activated (aPC) and anti-apoptotic signalling. This study was carried out to analyze the expression, cell surface exposition, shedding normal malignant prostate lines.EPCR expression is up-regulated both at mRNA levels invasive DU-145 PC-3 cells comparison epithelial (PrEC) less-invasive LNCaP...
Abstract Since direct oral anticoagulants (DOAC) are administered frequently to an elderly, co-morbid population, medical emergencies including trauma, acute bleeding or organ failure not uncommon. In these situations, the type, dosage time of last intake is often unknown and single substance analysis by functional tests only possible if contained in sample known. A reliable validated toxicology screen DOAC argatroban would be helpful inform attending physicians emergency department but also...
The direct thrombin inhibitor argatroban is indicated for the treatment of heparin-induced thrombocytopenia II, but it also used off-label to treat critically ill patients presenting with heparin resistance, severe antithrombin deficiency, or hypercoagulability. Direct drug monitoring not routinely available, and dosing mainly based on global coagulation assays such as activated partial thromboplastin time (PTT) diluted (TT), both which have limitations in
The analysis of aberrant DNA methylations is used for the diagnosis cancer as significant changes in gene methylation pattern are often detected during early carcinogenesis. In this study, we evaluated performance a two-step method that combines pre-amplification with ddPCR technique.By using ddPCR, dependence amplification efficiency methylated and unmethylated fragments on relevant MgCl2 concentration annealing temperature was established addition to primer design. We found can be adjusted...