A5047480914- Epigenetics and DNA Methylation
- Protein Kinase Regulation and GTPase Signaling
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Protease and Inhibitor Mechanisms
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Sphingolipid Metabolism and Signaling
- Lipoproteins and Cardiovascular Health
- Cellular transport and secretion
- Prostate Cancer Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adrenal and Paraganglionic Tumors
- Erythrocyte Function and Pathophysiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diabetes and associated disorders
- Cell Adhesion Molecules Research
- Hormonal Regulation and Hypertension
- Bladder and Urothelial Cancer Treatments
- Blood disorders and treatments
TU Dresden
2012-2024
University Hospital Carl Gustav Carus
2008-2024
Klinik und Poliklinik für Psychotherapie und Psychosomatik
1996-2015
Zimmer Biomet (United States)
2000
Institute of Clinical Cancer Research
2000
CS Diagnostics
1991
Activation and suppression of immune responses are crucial events during sepsis. Based on substantial new data, a complex picture differential immune-enhancing immunosuppressive actions adrenocortical steroids is emerging. The adrenal androgen dehydroepiandrosterone its precursor, dehydroepiandrosterone-sulfate, show considerable decrease with increasing age serve as functional antagonists to endogenous glucocorticoids. Therefore, we examined time-dependent changes in dehydroepiandrosterone,...
Abstract Epidemiologic studies have indicated that high intake of saturated fat and/or animal increases the risk colon and breast cancer. Omega‐3 PUFAs in fish oil (FO) can inhibit growth human cancer cells vitro vivo . These effects are related to uptake eicosapentaenoic acid (EPA) docosahexaenoic (DHA) into cellular substrate pool their competitive metabolism with arachidonic (AA) at cyclooxygenase 5‐lipoxygenase levels. The metabolites EPA DHA less inflammatory immunosuppressant potency...
Pheochromocytomas and paragangliomas (PPGLs) are catecholamine‐producing chromaffin cell tumors with diverse phenotypic features reflecting mutations in numerous genes, including MYC‐associated factor X ( MAX ). To explore whether differences among PPGLs reflect a MAX‐mediated mechanism opposing influences of hypoxia‐inducible (HIF)s HIF2α HIF1α, we combined observational investigations gene‐manipulation studies two pheochromocytoma lines. Among from 140 patients, due to were characterized...
Mutational inactivation of the succinate dehydrogenase (SDH) complex is a well-described cause tumor development in pheochromocytomas/paragangliomas (PPGLs) and gastrointestinal stromal tumors (GISTs). Epigenetic SDHC gene more recently discovered phenomenon, which so far has only been described GISTs PPGLs from patients with Carney triad syndrome.A 33-year-old patient presented two abdominal paragangliomas (PGLs) an adrenocortical adenoma. Both PGLs showed high succinate:fumarate ratios...
Objective: In order to evaluate the traumatic effects of median sternotomy and cardiopulmonary bypass (CPB) in conventional minimally invasive coronary artery grafting, inflammatory response was studied a prospective randomized trial patients referred single-vessel grafting. Methods: Four surgical techniques were compared: group 1, with CPB ten (eight male, two female; aged 59.6±11.0 years (mean±SD)); 2, off-pump (seven three 65.1±10.0 years); 3, minithoracotomy female, 61.2±10.4 4, (nine...
Upregulation of group IIA phospholipase A(2) (sPLA(2)-IIA) correlates with prostate tumor progression suggesting prooncogenic properties this protein. Here, we report data on expression three different sPLA(2) isozymes (groups IIA, V, and X) in normal (PrEC) malignant (DU-145, PC-3, LNCaP) human cell lines. All studied lines constitutively expressed sPLA(2)-X, whereas sPLA(2)-V transcripts were identified only cells. In contrast, no sPLA(2)-IIA was found PrEC DU-145 cells, but it by...
Triple A syndrome is a human autosomal recessive disorder characterized by adrenal insufficiency, achalasia, alacrima, and neurological abnormalities affecting the central, peripheral, autonomic nervous systems. In humans, this disease caused mutations in AAAS gene, which encodes ALADIN, protein that belongs to family of WD-repeat proteins localizes nuclear pore complexes. To analyze function gene context whole organism an attempt obtain animal model for triple syndrome, we generated mice...
The M-type phospholipase A2 receptor (PLA2R1) plays a crucial role in several signaling pathways and may act as tumor-suppressor. This study examined the expression methylation of PLA2R1 gene Jurkat U937 leukemic cell lines its patients with myelodysplastic syndrome (MDS) or acute leukemia.Sites locus were identified by sequencing bisulfite-modified DNA fragments. Methylation specific-high resolution melting (MS-HRM) analysis was then carried out to quantify at 5'-CpG sites differences...
It has recently been proposed that the M-type phospholipase A2 receptor (PLA2R1) acts as a tumour suppressor in certain malignancies including mammary cancer. Considering DNA methylation is an important regulator of gene transcription during carcinogenesis, current study we analyzed PLA2R1 expression, promoter methylation, and selected micro RNA (miRNA) levels normal human epithelial cells (HMEC) cancer cell lines.Levels methyltransferases (DNMT) specific mRNA were determined using real-time...