A5061580306- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Dialysis and Renal Disease Management
- Iron Metabolism and Disorders
- Erythropoietin and Anemia Treatment
- Vitamin D Research Studies
- Diabetes Management and Research
- Cancer, Hypoxia, and Metabolism
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Parathyroid Disorders and Treatments
- Neuroblastoma Research and Treatments
- Retinopathy of Prematurity Studies
- Cardiovascular Health and Disease Prevention
- Adrenal Hormones and Disorders
- Hormonal and reproductive studies
- Radiation Effects and Dosimetry
- Radiation Therapy and Dosimetry
- Cardiovascular Disease and Adiposity
- Carcinogens and Genotoxicity Assessment
- Diabetes Management and Education
- Bone health and treatments
- Chronic Disease Management Strategies
King's College London
2019-2024
University Hospital Carl Gustav Carus
2015-2019
TU Dresden
2015-2019
National Technical University of Athens
2013-2016
Mass spectrometric-based measurements of the steroid metabolome have been introduced to diagnose disorders featuring abnormal steroidogenesis. Defined reference intervals are important for interpreting such data.Liquid chromatography-tandem mass spectrometry was used establish 16 steroids (pregnenolone, progesterone, 11-deoxycorticosterone, corticosterone, aldosterone, 18-oxocortisol, 18-hydroxycortisol, 17-hydroxyprogesterone, 21-deoxycortisol, 11-deoxycortisol, cortisol, cortisone,...
Detrimental effects of ionizing radiation (IR) are correlated to the varying efficiency IR induce complex DNA damage. A double strand break (DSB) can be considered simpler form These types damage consist DSBs, single breaks (SSBs) and/or non-DSB lesions such as base damages and apurinic/apyrimidinic (AP; abasic) sites in different combinations. Enthralling theoretical (Monte Carlo simulations) experimental evidence suggests an increase complexity therefore repair resistance with linear...
Plasma or urinary metanephrines are recommended for screening of pheochromocytomas and paragangliomas (PPGLs). Measurements free rather than deconjugated additional measurements methoxytyramine represent other developments. For all there is need reference intervals.Plasma free, O-methylated catecholamine metabolites were measured by LC-MS/MS in specimens from 590 hypertensives normotensives. Reference intervals optimized using data 2,056 patients tested PPGLs.Multivariate analyses,...
Mutational inactivation of the succinate dehydrogenase (SDH) complex is a well-described cause tumor development in pheochromocytomas/paragangliomas (PPGLs) and gastrointestinal stromal tumors (GISTs). Epigenetic SDHC gene more recently discovered phenomenon, which so far has only been described GISTs PPGLs from patients with Carney triad syndrome.A 33-year-old patient presented two abdominal paragangliomas (PGLs) an adrenocortical adenoma. Both PGLs showed high succinate:fumarate ratios...
This study assessed whether vitamin K, given with oral bisphosphonate, calcium and/or D has an additive effect on fracture risk in post-menopausal women osteoporosis. No difference bone density or turnover was observed although K
Patients with chronic kidney disease (CKD) are often iron deficient, even when not anemic. This trial evaluated whether supplementation enhances exercise capacity of nonanemic patients CKD who have iron-deficiency.Prospective, multicenter double-blind randomized controlled nondialysis and iron-deficiency but without anemia (Hemoglobin [Hb] >110 g/l). were assigned 1:1 to intravenous (IV) therapy, or placebo. An 8-week program commenced at week 4. The primary outcome was the mean...
Abstract Background Neuroblastoma, the most common extracranial solid tumor of childhood, produces catecholamines that are metabolized within cells. Homovanillic acid (HVA) and vanillylmandelic (VMA), end products catecholamine metabolism, have limited accuracy for testing tumors. This study assessed whether metabolites produced in earlier steps metabolism might offer improved diagnostic over urinary HVA VMA. Procedure Plasma concentrations 3‐methoxytyramine, normetanephrine, metanephrine...
Active vitamin D deficiency is associated with increased aortic-pulse wave velocity (Ao-PWV) in people type 2 diabetes (T2DM) and chronic kidney disease (CKD). There are no randomised controlled trials investigating the effect of active treatment on Ao-PWV T2DM CKD.A 48-week duration single-centre double-blind parallel-group trial examined impact oral 1,25 dihydroxyvitamin (calcitriol 0.25 mcg OD) as compared to placebo a primary endpoint Ao-PWV. People stable stage 3 CKD intact parathyroid...
The mechanisms that explain the cardio-renal benefits of sodium glucose co-transporter 2 (SGLT-2) inhibitors are unknown. effect SGLT-2 on arterial aging, measured by Aortic Pulse Wave Velocity (Ao-PWV) and Soluble Klotho (s-Klotho), a circulating anti-aging biomarker health also unclear.A 24-week single center randomized controlled trial (registry number/ EudraCT Number: 2013-004042-42) comparing Dapagliflozin Ramipril (D+R) versus (R) primary endpoint urine albumin excretion rate (AER)...
People with diabetes and chronic kidney disease (CKD) are predisposed to bone mineral disorders increased fracture risk. There is limited data on the effect of calcitriol turnover markers (BTMs) in people type 2 (T2DM) stage 3 CKD. In a pre-specified secondary endpoint analysis 48-week randomized placebo controlled double-blind trial, we studied effects oral 0.25 μg once daily circulating BTMs that included osteocalcin (OCN), C-terminal telopeptide I collagen (CTXI), procollagen N-propeptide...
Objectives We aim to evaluate estimated glomerular filtration rate (eGFR) patterns of progression in a multiethnic cohort people with type I diabetes mellitus and baseline eGFR ≥45 mL/min/1.73 m 2 . Design Observational cohort. Setting People clinical diagnosis 1 diabetes, attending two university hospital-based outpatient clinics, South London between 2004 2018. Participants studied 1495 participants (52% females, 81% white, 12% African-Caribbean 7% others). Primary secondary outcome...
OBJECTIVE There is limited information on the effect of ethnicity development referable sight-threatening diabetic retinopathy (STDR) in people with type 1 diabetes. This study describes risk factors for STDR a diverse cohort diabetes attending regional eye screening service. RESEARCH DESIGN AND METHODS Clinical and digital retinal imaging data from 1,876 (50% women, 72.1% Caucasian, 17.3% African Caribbean, 2.9% Asian, 7.6% other) no at baseline, surveillance were reviewed. Referable was...
Abstract Aims/hypothesis The role of HbA 1c variability in the progression diabetic kidney disease is unclear, with most studies to date performed White populations and limited data on its predicting advanced outcomes. Our aim was evaluate if long-term intra-individual a risk factor for (defined as an eGFR decline ≥50% from baseline final <30 ml/min per 1.73 m 2 ) ethnically heterogeneous cohort people type 1 diabetes preserved ≥45 at baseline. Methods Electronic health record attending...
OBJECTIVE The aim of the study was to identify demographic and clinical features in an urban cohort people with type 1 diabetes who developed a ≥50% decline estimated glomerular filtration rate (eGFR). RESEARCH DESIGN AND METHODS We evaluated 5,261 (51% female, 13.4% African Caribbean) baseline eGFR &gt;45 mL/min/1.73 m2 between 2004 2018. primary end point from final &lt;30 m2. calculated using Chronic Kidney Disease Epidemiology Collaboration equation. RESULTS Of cohort, 263 (5%)...
Abstract Background Many people living with chronic kidney disease (CKD) are iron deficient, even though they may not be anaemic. The Iron and Muscle study aims to evaluate whether supplementation reduces symptoms of fatigue, improves muscle metabolism, leads enhanced exercise capacity physical function. We report here the trial design baseline characteristics. Methods This is a prospective, double-blind multicentre randomised controlled (RCT) including 75 non-dialysis stage 3–4 CKD patients...
This study evaluated the cost effectiveness of an intensive lifestyle modification (LSM) intervention delivered by peer educators for prevention type 2 diabetes mellitus in a young at-risk population low healthcare resource setting.The aim this was to evaluate short-term and long-term urban Sri Lanka.This economic evaluation using outcome data from randomized controlled trial. We 3539 healthy individuals aged 5-40 years with risk factors either 3-monthly (P-LSM n = 1727) or 12-monthly (C-LSM...
Introduction The four variable kidney failure (KF) risk equation (KFRE) is recommended to estimate KF (ie, need for dialysis or transplantation). Earlier referral clinical services people with high-risk of can ensure appropriate care, education and support are in place pre-emptively. There limited data on investigating the performance KFRE estimating end-stage disease (ESKD) type 2 diabetes mellitus (T2DM) chronic (CKD). primary ESKD endpoint event was defined as estimated glomerular...
Renal cell carcinoma (RCC) is among the 10 most common cancer entities and can be categorised into distinct subtypes by differential expression of Krebs cycle genes. We investigated predictive value several targeted metabolites with regards to tumour stages patient survival in an unselected cohort 420 RCCs. Unsupervised hierarchical clustering metabolite ratios identified two main clusters separated α-ketoglutarate (α-KG) levels sub-clusters oncometabolite 2-hydroxyglutarate (2HG)....
<p> </p> <p><strong>Objective</strong>: The aim of the study was to identify demographic and clinical features in an urban cohort people with type 1 diabetes who developed ≥50% decline estimated glomerular filtration rate (eGFR). <p><strong>Research design methods</strong>: We evaluated 5261 (51% female, 13.4% African-Caribbean) baseline eGFR >45ml/min/1.73m2. Primary endpoint from a final <30ml/min/1.73m2. calculated by Chronic Kidney...
<p> </p> <p><strong>Objective</strong></p> <p>There is limited information on the effect of ethnicity development referable sight-threatening diabetic retinopathy (STDR) in people with type 1 diabetes. To describe risk-factors for STDR a diverse cohort diabetes attending regional eye screening service <p><strong>Research design and methods</strong></p> <p>Clinical digital retinal imaging data from 1876 (50% female, 72.1%...