A5004990727- Vitamin D Research Studies
- Bone health and osteoporosis research
- Muscle metabolism and nutrition
- Parathyroid Disorders and Treatments
- Exercise and Physiological Responses
- Bone health and treatments
- Occupational Health and Performance
- Sports Performance and Training
- Vitamin C and Antioxidants Research
- Pharmacological Effects and Toxicity Studies
- Body Composition Measurement Techniques
- Genetic Syndromes and Imprinting
- Fibroblast Growth Factor Research
- Nutrition and Health in Aging
- Diet and metabolism studies
- Genomics, phytochemicals, and oxidative stress
- Multiple Sclerosis Research Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Metabolism, Diabetes, and Cancer
- Knee injuries and reconstruction techniques
- Birth, Development, and Health
- Bone fractures and treatments
- Medical Imaging and Pathology Studies
- Parkinson's Disease Mechanisms and Treatments
- Growth Hormone and Insulin-like Growth Factors
University of East Anglia
2016-2025
Norfolk and Norwich University Hospital
2017-2025
Norwich Research Park
2014-2024
Purdue University West Lafayette
2016-2024
Norfolk and Norwich University Hospitals NHS Foundation Trust
2021-2024
Norwich University
2013-2024
University Hospital Foundation
2024
University of Washington
2023
Allen Institute
2023
Columbia University
2014-2023
Skeletal muscle is a direct target for vitamin D. Observational studies suggest that low 25[OH]D correlates with functional recovery of skeletal following eccentric contractions in humans and crush injury rats. However, definitive association yet to be established. To address this gap knowledge relation damage repair, randomised, placebo-controlled trial was performed 20 males insufficient concentrations serum 25(OH)D (45 ± 25 nmol/l). Prior 6 wk supplemental D 3 (4,000 IU/day) or placebo...
ABSTRACT Most trials of vitamin D supplementation have shown no benefits on bone mineral density (BMD), although severe deficiency causes osteomalacia, which is associated with profound BMD deficits. Recently, the ViDA-BMD study from New Zealand demonstrated a threshold baseline 25-hydroxyvitamin (25OHD; 30 nmol/L) below did benefit BMD. We now reexamined data similar trial in Aberdeen to determine whether 25OHD nmol/L also observed that database. The recruited 305 postmenopausal women late...
Randomized controlled trials (RCTs) to determine the influence of vitamin D on BMC and fracture risk in children Black African ancestry are lacking. We conducted a sub-study (n = 450) nested within phase 3 RCT weekly oral supplementation with 10 000 IU D3 vs placebo for yr HIV-uninfected Cape Town schoolchildren aged 6-11 yr. Outcomes were at whole body less head (WBLH) LS serum 25-hydroxyvitamin (25(OH)D3), PTH, alkaline phosphatase, C-terminal telopeptide, PINP. Incidence fractures was...
Purpose Supplementation with dietary forms of vitamin D is commonplace in clinical medicine, elite athletic cohorts, and the general population, yet response all major metabolites to high doses poorly characterized. We aimed identify responses moderate- high-dose supplemental D3. Methods A repeated-measures design was implemented which 46 professional European athletes were block randomized based on their basal 25[OH]D concentration into two treatment groups. Athletes received either 35,000...
To determine the relationship between vitamin D status and exercise performance in a large, prospective cohort study of young men women across seasons (study 1). Then, randomized, placebo-controlled trial, to investigate effects on achieving sufficiency (serum 25(OH)D ≥ 50 nmol·L) by unique comparison safe, simulated-sunlight oral D3 supplementation wintertime 2).In 1, we determined with 967 military recruits. In 2, 137 received either placebo, simulated sunlight (1.3× standard erythemal...
Currently there are no effective therapies available for the excruciating neuropathic pain that develops after spinal cord injuries (SCI). As such, a great deal of effort is being put into investigation novel therapeutic targets can alleviate this pain. One such target acrolein, highly reactive aldehyde produced as byproduct oxidative stress and inflammation capable activating transient receptor potential ankyrin 1 (TRPA1) cation channel, known to be involved in transmission propagation...
This study examined whether consuming collagen peptides (CP) before and after strenuous exercise alters markers of muscle damage, inflammation bone turnover. Using a double-blind, independent group's design, 24 recreationally active males consumed either 20 g day−1 CP or placebo control (CON) for 7 days 2 performing 150 drop jumps. Maximal isometric voluntary contractions, countermovement jumps (CMJ), soreness (200 mm visual analogue scale), pressure pain threshold, Brief Assessment Mood...
Key points Reduced carbohydrate (CHO) availability before and after exercise may augment endurance training‐induced adaptations of human skeletal muscle, as mediated via modulation cell signalling pathways. However, it is not known whether such responses are by CHO restriction, energy restriction or a combination both. In recovery from twice per day training protocol where muscle glycogen concentration maintained within 200–350 mmol kg −1 dry weight (dw), we demonstrate that acute...
To determine whether weekly oral supplementation with 10,000 IU vitamin D
Military training increases tibial density and size. Female sex hormones may influence the adaption of bone to loading, but it is unknown if women using different hormonal contraceptives adapt similarly military training. One hundred sixteen (57 not [non-users], 38 combined oral contraceptive pill [COCP] users, 21 depot medroxyprogesterone acetate [DMPA] users) completed this study. Tibial volumetric mineral (vBMD) geometry were measured by peripheral quantitative computed tomography (4 %,...
Heavy training is associated with increased respiratory infection risk and antimicrobial proteins are important in defence against oral tract infections. We examined the effect of 14 weeks vitamin D3 supplementation (5000 IU/day) on resting plasma cathelicidin concentration salivary secretion rates secretory immunoglobulin A (SIgA), cathelicidin, lactoferrin lysozyme athletes during a winter period. Blood saliva were obtained at start study from 39 healthy men who randomly allocated to...
The Mediterranean diet (MD) is widely recommended for the prevention of chronic disease, but evidence a beneficial effect on bone health lacking. aim this study was to examine Mediterranean-like dietary pattern [NU-AGE (New Dietary Strategies Addressing Specific Needs Elderly Population Healthy Aging in Europe)] indexes inflammation with number secondary endpoints, including mineral density (BMD) and biomarkers collagen degradation 1-y multicenter randomized controlled trial (RCT; NU-AGE)...
Abstract Vitamin D status, assessed by serum concentration of 25(OH)D, is the prime candidate marker for many disease-association studies, but interplay between subsequent 1,25-dihydroxyvitamin (1,25(OH) 2 D) and 24,25-dihydroxyvitamin (24,25(OH) metabolites unclear. In this study, we conducted an analysis from a large cohort healthy, physically fit, young army recruits (n = 940). We found significant, inverse relationship 25(OH)D 1,25(OH) D:24,25(OH) vitamin metabolite ratio (VMR) (r Exp...
Observational studies suggest an association between vitamin D deficiency and adverse outcomes of critical illness identify it as a potential risk factor for the development lung injury. To determine whether preoperative administration oral high-dose cholecalciferol ameliorates early acute injury postoperatively in adults undergoing elective esophagectomy.A double-blind, randomized, placebo-controlled trial.Three large U.K. university hospitals.Seventy-nine adult patients esophagectomy were...
Bone resorption is increased after running, with no change in bone formation. Feeding during exercise might attenuate this increase, preventing associated problems for bone. This study investigated the immediate and short-term metabolic responses to carbohydrate (CHO) feeding treadmill running. Ten men completed two 7-day trials, once being fed CHO (8% glucose immediately before, every 20 min during, at a rate of 0.7 g CHO·kg body mass −1 ·h ) placebo (PBO). On day 4 each trial, participants...
Abstract Purpose To determine serum 25(OH)D and 1,25(OH) 2 D relationship with hepatitis B vaccination (study 1). Then, to investigate the effects on of achieving vitamin sufficiency (serum ≥ 50 nmol/L) by a unique comparison simulated sunlight oral 3 supplementation in wintertime 2). Methods Study 1 involved 447 adults. In study 2, days after initial vaccination, 119 men received either placebo, (1.3 × standard-erythema dose, /week for 4 weeks then 8 weeks) or (1000 IU/day 400 weeks). We...