A5027402377- Traumatic Brain Injury Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Parkinson's Disease Mechanisms and Treatments
- Pain Mechanisms and Treatments
- Ion Channels and Receptors
- Receptor Mechanisms and Signaling
- Genomics, phytochemicals, and oxidative stress
- Adipose Tissue and Metabolism
- Memory and Neural Mechanisms
- Multiple Sclerosis Research Studies
- Nerve injury and regeneration
- Stroke Rehabilitation and Recovery
- Neonatal and fetal brain pathology
- Cardiac Arrest and Resuscitation
- Synthesis and biological activity
- Nutrition, Genetics, and Disease
- Antioxidant Activity and Oxidative Stress
- Neurological and metabolic disorders
- S100 Proteins and Annexins
- Fungal Plant Pathogen Control
- Sleep and Wakefulness Research
- Nuclear Receptors and Signaling
- Alcohol Consumption and Health Effects
Purdue University West Lafayette
2012-2021
Jackson Laboratory
2018
Purdue University Institute for Cancer Research
2012
Wake Forest University
2006-2012
Abstract A recent clinical study demonstrated that damage to the insular cortex can disrupt tobacco addiction. The neurobiological mechanisms for this effect are not yet understood. In we used an animal model of nicotine addiction examine possibility changes in levels dopamine (DA)‐ and cAMP‐regulated phosphoprotein 32 kDa (DARPP‐32), a enriched DA neurons containing D1 receptors, may be associated with vulnerability Once rats acquired self‐administration, they were given unlimited access...
Currently there are no effective therapies available for the excruciating neuropathic pain that develops after spinal cord injuries (SCI). As such, a great deal of effort is being put into investigation novel therapeutic targets can alleviate this pain. One such target acrolein, highly reactive aldehyde produced as byproduct oxidative stress and inflammation capable activating transient receptor potential ankyrin 1 (TRPA1) cation channel, known to be involved in transmission propagation...
Abstract Acrolein, an endogenous aldehyde, has been shown to be involved in sensory hypersensitivity after rat spinal cord injury ( SCI ), for which the pathogenesis is unclear. Acrolein can directly activate a pro‐algesic transient receptor protein ankyrin 1 TRPA 1) channel that exists neurons. Both acrolein and mRNA are elevated post , contributes activation of by consequently, neuropathic pain. In current study, we further showed that, post‐ elevation not only dorsal root ganglias but...
OBJECT Blast-induced neurotrauma (BINT), if not fatal, is nonetheless potentially crippling. It can produce a wide array of acute symptoms in moderate-to-severe exposures, but mild BINT (mBINT) characterized by the distinct absence clinical abnormalities. The lack observable indications for mBINT particularly alarming, as these injuries have been linked to severe long-term psychiatric and degenerative neurological dysfunction. Although sequelae are extensively documented, underlying...
Alzheimer disease (AD) has a complex etiology arising from largely unknown interactions between genetic and environmental factors. Even in populations with highly penetrant, disease-causing familial AD mutations, there is wide variation onset progression, suggesting that clinical symptoms are modified by genetics environment. Identification of such modifiers critical, as mechanisms promote resilience to deleterious unhealthy diet, or aging represent promising therapeutic targets for other...
Blast-induced traumatic brain injury has been associated with neurodegenerative and neuropsychiatric disorders. To date, although damage due to oxidative stress appears be important, the specific mechanistic causes of such disorders remain elusive. Here, determine mechanical variables governing tissue eventually cascading into cognitive deficits, we performed a study on mechanics rat under blast conditions. this end, experiments were carried out analyse correlate post-injury distribution...
Demyelination and axonal injury are the key pathological processes in multiple sclerosis (MS), driven by inflammation oxidative stress. Acrolein, a byproduct instigator of stress, has been demonstrated as neurotoxin experimental autoimmune encephalomyelitis (EAE), an animal model MS. However, due to invasive nature acrolein detection using immunoblotting techniques, investigation MS limited models. Recently, specific acrolein-glutathione metabolite, 3-HPMA, urine, enabling noninvasive...
Functional impairment of the orbital and medial prefrontal cortex underlies deficits in executive control that characterize addictive disorders, including alcohol addiction. Previous studies indicate alters glutamate neurotransmission one substrate these effects may be through reconfiguration subunits constituting ionotropic receptor (iGluR) complexes. Glutamatergic transmission is integral to cortico-cortical cortico-subcortical communication alcohol-induced changes abundance and/or their...
Background: Recent evidence indicates that functional impairment of the orbital and medial fields prefrontal cortex may underlie deficits in executive control behavior characterize addictive disorders, including alcohol addiction. Moreover, previous studies have indicated alters GABA neurotransmission one substrate these effects be through reconfiguration subunits constituting A receptor complex. Given GABAergic transmission has an integral role cortical processing, influencing local...
A recipe for potency: novel series of bis(indolyl)-1,3,4-oxadiazoles was prepared from the corresponding hydrazide-hydrazones via iodobenzene diacetate-promoted oxidative cyclization. Evaluation against a panel human cancer cell lines revealed that some derivatives possess potent cytotoxicity with tunable selectivity different types. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They...
Full Scale Testing of Biofilters for Odor Control at the Los Angeles County Sanitation Districts' Joint Water Pollution Plant Biosolids Handling FacilitiesOdor control has always been a primary concern Districts (Districts) in operation its wastewater treatment facilities. During dewatering, conveying and storage biosolids there can be potential to produce significant off-site odors. The operate one largest dewatering facilities United States Joint...Author(s)Robert MortonPhil AckmanGlen...
Alzheimer's disease (AD) often presents with multiple non-cognitive comorbidities including sensorimotor deficits, significantly impacting the quality of life for patients and caregivers. Mechanisms underlying these multifactorial symptoms are poorly understood, yet their identification will be critical to find develop effective therapeutic targets. We recently developed a novel panel genetically diverse mice harboring five causal human familial AD mutations (AD-BXDs) have previously...